Impact of osteogenic activity on degenerative aortic valve disease in patients with osteoporotic hip fracture

Furugen, Makoto; Watanabe, Nozomi; Nishino, Shun; Kimura, Toshiyuki; Ashikaga, Keiichi; Kuriyama, Nehiro; Shibata, Yoshisato

doi:10.1016/j.jjcc.2021.05.014

Cited by 3 publications

(3 citation statements)

References 29 publications

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“… 6 Interestingly, valvular calcifications exhibit features of bone formation, and ectopic calcification is frequently accompanied by decreased mineral density or disturbed bone turnover. 9 Moreover, osteoporosis (ie, severe decrease in bone mineral density accompanied by increased fracture risk) has been proposed as an etiologic factor contributing to the calcific changes in the aortic valve as well as in other cardiac structures, a phenomenon called “calcification paradox”. 15 , 16 Regardless of the etiological link, 16 , 17 patients with SAS can suffer a fall and develop an HFx.…”

Section: Diagnosing Severe Aortic Stenosis In Patients With Hip Fract...mentioning

confidence: 99%

“… 5 Although there are scarce reports analyzing the concomitance of AS and HFx, about 3 to 8% of hospitalized patients with HFx have moderate or severe AS (SAS) ( Table 1 ). 6 , 7 , 8 , 9 This is not surprising, since the incidence of SAS is ⁓5% in patients >75 years. 5 SAS places the patient at risk for perioperative cardiac complications, 10 , 11 having 3 to 4-fold increased 30-day mortality compared to patients with HFx without SAS, 6 , 8 , 12 Furthermore, 1-year mortality in this group reaches ⁓50%.…”

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confidence: 92%

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Aortic Stenosis Management in Patients With Acute Hip Fracture

Terré,

Torrado,

George

et al. 2024

JACC: Advances

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Section: Diagnosing Severe Aortic Stenosis In Patients With Hip Fract...mentioning

confidence: 99%

mentioning

confidence: 92%

Aortic Stenosis Management in Patients With Acute Hip Fracture

Terré,

Torrado,

George

et al. 2024

JACC: Advances

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“…Mild-to-moderate and severe AS have been incidentally observed in 26% (142/550) [ 6 ] and 3.2% (73/2274) [ 7 ] of patients with osteoporotic hip fractures, respectively. The imbalance between bone resorption and formation has been suggested to play a role in AS progression [ 8 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

Increasing baseline aortic valve peak flow velocity is associated with progression of aortic valve stenosis in osteoporosis patients—a possible link to low vitamin D status

Tsuruda,

Funamoto,

Suzuki

et al. 2023

Arch Osteoporos

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Purpose The purpose of this study was to investigate the morphological characteristics of the aortic valve and identify factors associated with the progression of aortic valve stenosis (AS) in osteoporosis patients. Methods In this single-center prospective cohort study, we recruited 10 patients (mean age: 75 ± 7 years, 90% female) who were taking anti-resorptive medicines at the outpatient clinic of University of Miyazaki Hospital, Japan. Baseline assessments, including transthoracic echocardiogram, blood sampling, and dual energy X-ray absorptiometry, were performed. Follow-up assessments were conducted at 6, 12, 18, and 24 months. Results During the 2-year follow-up, three patients with aortic valve peak flow velocity (AV PFV) ≥2 m/s at baseline developed moderate AS, which is defined as AV PFV ≥3 m/s. However, seven patients with AV PFV <2 m/s did not exhibit any progression of AS. There were significant variations in terms of bone mineral density, T-score values, and biomarkers associated with bone turnover (i.e., bone alkaline phosphatase, tartrate-resistance acid phosphatase-5b) among the enrolled patients, but none of these factors were found to be associated with the progression of AS. All patients exhibited low vitamin D status, with a median level of 16.1 ng/mL (25th percentile, 9.7 ng/mL; 75th percentile, 23 ng/mL). The baseline levels of AV PFV values were negatively correlated with 25-hydroxyvitamin D levels, determined by univariate linear regression analysis (beta coefficient = -0.756, 95% confidence interval, -0.136 ̶ -0.023, p = 0.011). Conclusion Our data suggest that low vitamin D status might be a potential risk factor for the progression of AS in osteoporosis patients undergoing treatment with anti-resorptive medicines. Summary Elderly patients with osteoporosis patients exhibited a subset of aortic valve stenosis. Our data suggest that the baseline aortic valve peak flow velocity predicts the progression of aortic valve stenosis, and there might be an association between the progression and the co-existing low vitamin D status in these patients.

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Elucidating common biomarkers and pathways of osteoporosis and aortic valve calcification: insights into new therapeutic targets

Lan,

Peng,

Shen

et al. 2024

Sci Rep

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Background: Osteoporosis and aortic valve calcification, prevalent in the elderly, have unclear common mechanisms. This study aims to uncover them through bioinformatics analysis. Methods: Microarray data from GEO was analyzed for osteoporosis and aortic valve calcification. Differential expression analysis identified co-expressed genes. SVM-RFE and random forest selected key genes. GO and KEGG enrichment analyses were performed. Immunoinfiltration and GSEA analyses were subsequently performed. NetworkAnalyst analyzed microRNAs/TFs. HERB predicted drugs, and molecular docking assessed targeting potential. Results: Thirteen genes linked to osteoporosis and aortic valve calcification were identified. TNFSF11, KYNU, and HLA-DMB emerged as key genes. miRNAs, TFs, and drug predictions offered therapeutic insights. Molecular docking suggested 17-beta-estradiol and vitamin D3 as potential treatments. Conclusion: The study clarifies shared mechanisms of osteoporosis and aortic valve calcification, identifies biomarkers, and highlights TNFSF11, KYNU, and HLA-DMB. It also suggests 17-beta-estradiol and vitamin D3 as potential effective treatments.

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Impact of osteogenic activity on degenerative aortic valve disease in patients with osteoporotic hip fracture

Cited by 3 publications

References 29 publications

Aortic Stenosis Management in Patients With Acute Hip Fracture

Aortic Stenosis Management in Patients With Acute Hip Fracture

Increasing baseline aortic valve peak flow velocity is associated with progression of aortic valve stenosis in osteoporosis patients—a possible link to low vitamin D status

Elucidating common biomarkers and pathways of osteoporosis and aortic valve calcification: insights into new therapeutic targets

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