Impact of Ovarian Hyperstimulation on Thyroid Function in Women with and without Thyroid Autoimmunity

Poppe, Kris; Glinoer, Daniel; Tournaye, Herman; Schiettecatte, Johan; Devroey, Paul; Steirteghem, André Van; Haentjens, Patrick; Velkeniers, Brigitte

doi:10.1210/jc.2004-0105

Cited by 103 publications

(89 citation statements)

References 14 publications

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“…The studies differed in various aspects. Some had followed a cohort (235)(236)(237)248,250,252,253,(260)(261)(262)(263)(264)(265)(266)(267)(268)(269)(270)(271) (B,A,B,B,B,B,B,A,B-B) and others were "case-controlled" studies (251,254,(272)(273)(274)(275) (C,C,C,C,C).…”

Section: What Is the Role Of Thyroid Autoimmunity In Fertility And Prmentioning

confidence: 99%

Clinical practice guidelines for the management of hypothyroidism

Brenta

Vaisman

Sgarbi

et al. 2013

Arq Bras Endocrinol Metab

125

123

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Introduction: Hypothyroidism has long been known for its effects on different organ systems, leading to hypometabolism. However, subclinical hypothyroidism, its most prevalent form, has been recently related to cardiovascular risk and also to maternal-fetal complications in pregnant women. Objectives: In these clinical practice guidelines, several aspects of this field have been discussed with the clear objectives of helping physicians treat patients with hypothyroidism, and of sharing some of our Latin American-based clinical experience. Materials and methods: The Latin American Thyroid Society commissioned a Task Force on Hypothyroidism to develop evidence-based clinical guidelines on hypothyroidism. A systematic review of the available literature, focused on the primary databases of MedLine/PubMed and Lilacs/SciELO was performed. Filters to assess methodological quality were applied to select the best quality studies. The strength of recommendation on a scale from A-D was based on the Oxford Centre for Evidence--based Medicine, Levels of Evidence 2009, allowing an unbiased opinion devoid of subjective viewpoints. The areas of interest for the studies comprised diagnosis, screening, treatment and a special section for hypothyroidism in pregnancy. Results: Several questions based on diagnosis, screening, treatment of hypothyroidism in adult population and specifically in pregnant women were posed. Twenty six recommendations were created based on the answers to these questions. Despite the fact that evidence in some areas of hypothyroidism, such as therapy, is lacking, out of 279 references, 73% were Grade A and B, 8% Grade C and 19% Grade D. Conclusions: These evidence-based clinical guidelines on hypothyroidism will provide unified criteria for management of hypothyroidism throughout Latin America. Although most of the studies referred to are from all over the world, the point of view of thyroidologists from Latin America is also given. Arq Bras Endocrinol Metab. 2013;57(4):265-99

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Section: What Is the Role Of Thyroid Autoimmunity In Fertility And Prmentioning

confidence: 99%

Clinical practice guidelines for the management of hypothyroidism

Brenta

Vaisman

Sgarbi

et al. 2013

Arq Bras Endocrinol Metab

125

123

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“…15 Concurrently, corpus luteum insufficiency due to disruption of LH release and hyperpolactineamia due to increased TRH release may also increase negative influences over normal menstrual cycle. 10,14 In hypothyroidism, even though elevated TSH may reduce sex hormone binding protein (SHBP), increasing free testosterone and estradiol level, total serum level of these hormones are usually low. 21 Also, reduction in metabolic clearance of androstenedione and estron may increase aromatization of peripheral estrogens.…”

Section: Hypothyroidismmentioning

confidence: 99%

“…9 Rapid estrogen elevation during ovarian hyper stimulation leads to an increase in TBG and decrease in free T4 levels, consequently increase in TSH. 7 10 Thyroid diseases are the most common endocrine disease in females at reproductive age. 11 Due to above mentioned features of thyroid hormones, evaluation of thyroid functions during both pregnancy and treatment of infertility and treating relevant pathologies become important.…”

Section: Introductionmentioning

confidence: 99%

Thyroid disorders and fertility

Karaca

Akpak

2015

Int J Res Med Sci

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“…In the absence of studies comparing these different approaches, this survey has highlighted inconsistency in clinicians' approach for optimizing L-T 4 replacement in hypothyroid women planning pregnancy (Table 2). For hypothyroid women undergoing ovarian hyperstimulation, there was an increased trend to optimize the dose of L-T 4 before the procedure (Table 2), an approach supported by studies showing a rapid increase in TSH level in hypothyroid women who become pregnant following ovarian hyperstimulation (13). There was, however, general consensus on the target thyroid function for pregnant hypothyroid women on L-T 4 with most responders (86%) aiming to achieve TSH and FT 4 within the trimester-specific reference range or TSH !2.5 mU/l in the first trimester and !3 mU/l in the later trimesters (Table 4), as recommended by the guidelines (4, 7).…”

Section: Recommendationsmentioning

confidence: 99%

Treatment and screening of hypothyroidism in pregnancy: results of a European survey

Vaidya

Hubalewska‐Dydejczyk

Laurberg

et al. 2012

European Journal of Endocrinology

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Background: Maternal hypothyroidism in pregnancy is associated with several adverse outcomes. The Endocrine Society Guidelines for the management of thyroid diseases in pregnancy were published in 2007; however, impact of the guidelines in routine clinical practice is unknown. Therefore, we have carried out a survey of members of the European Thyroid Association (ETA) to study current practices relating to the management of hypothyroidism in pregnancy. Subjects and methods: In December 2010, we emailed an electronic questionnaire survey based on clinical case scenarios to 605 members of the ETA. Responses from 190 clinician members (from 28 European countries) were analyzed. Results: For a pregnant woman with newly diagnosed overt hypothyroidism, most responders initiated a full dose of L-thyroxine (L-T 4 ). For a woman with hypothyroidism planning pregnancy, 50% recommended increasing the dose of L-T 4 as soon as pregnancy is confirmed, whilst 43% favored testing thyroid function before adjusting the dose. Responders used diverse combinations of tests to monitor the dose of L-T 4 . The target of thyroid function tests that responders aimed to achieve with L-T 4 was also inconsistent. Forty-two percent responders or their institutions screened all pregnant women for thyroid dysfunction, 43% performed targeted screening of only the high-risk group, whilst 17% did not carry out systemic screening. Timing of the screening, tests used, and criteria for starting treatment and monitoring were variable. Conclusions: There is wide variation in the clinical practice relating to the treatment and screening of hypothyroidism during pregnancy in Europe.

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Impact of Ovarian Hyperstimulation on Thyroid Function in Women with and without Thyroid Autoimmunity

Cited by 103 publications

References 14 publications

Clinical practice guidelines for the management of hypothyroidism

Clinical practice guidelines for the management of hypothyroidism

Thyroid disorders and fertility

Treatment and screening of hypothyroidism in pregnancy: results of a European survey

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