Impact of P-selectin–PSGL-1 Axis on Platelet-Endothelium-Leukocyte Interactions in Fatal COVID-19

Granai, Massimo; Warm, Verena; Vogelsberg, Antonio; Milla, Jakob; Greif, Karen F.; Vogel, Ulrich; Bakchoul, Tamam; Rosenberger, Peter; Quintanilla-Martı́nez, Leticia; Schürch, Christian M.; Klingel, Karin; Fend, Falko; Bösmüller, Hans

doi:10.1016/j.labinv.2023.100179

Cited by 4 publications

(3 citation statements)

References 71 publications

(79 reference statements)

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“…P-Selectin was expressed in endothelial cells and platelet aggregates adhered to endothelium, as it has been reported in the early phase of COVID-19 (vascular phase). 33 Dead/euthanized groups (treated and untreated) showed quite close P-Selectin immunostaining. Surprisingly, a marked staining was observed in surviving mice (15 dpi) on the luminal surface of vessels, endothelial cells and platelet aggregates, with significant increased levels in untreated in comparison to sgp130Fc-treated mice in large and microcirculatory vessels ( Fig.…”

Section: Resultsmentioning

confidence: 91%

“… 27 Expression of P-Selectin was quantified according to the method recently reported by Granai M et al. 33 Briefly, 5–7 histological sections were analysed for each mouse of the different experimental groups, and five hot-spot regions per section were chosen using an area of 416,000 μm 2 with QuPath software. Areas with artefacts, such as tissue-tear, folding or background noise were excluded.…”

Section: Methodsmentioning

confidence: 99%

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Targeting IL-6 trans-signalling by sgp130Fc attenuates severity in SARS-CoV-2 -infected mice and reduces endotheliopathy

Rodríguez-Hernández,

Baena-Bustos,

Carneros

et al. 2024

eBioMedicine

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Section: Resultsmentioning

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Targeting IL-6 trans-signalling by sgp130Fc attenuates severity in SARS-CoV-2 -infected mice and reduces endotheliopathy

Rodríguez-Hernández,

Baena-Bustos,

Carneros

et al. 2024

eBioMedicine

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“…Although distinct neutrophil subpopulations have been characterized in different human pathologies and experimental models [13][14][15][16][17][18], their specific roles in preeclampsia remain under investigation. Numerous groups of molecules orchestrate the relationships between neutrophils, platelets, and endothelial cells, such as the P-selectin-PSGL-1 axis [19] via phosphodiesterase type-4 or Src family kinases and the vWF-glycoprotein Ibα axis [20].…”

Section: Introductionmentioning

confidence: 99%

Targeting Neutrophil Extracellular Trap Formation: Exploring Promising Pharmacological Strategies for the Treatment of Preeclampsia

Hernández González,

Pérez-Campos Mayoral,

Hernández-Huerta

et al. 2024

Pharmaceuticals

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Neutrophils, which constitute the most abundant leukocytes in human blood, emerge as crucial players in the induction of endothelial cell death and the modulation of endothelial cell responses under both physiological and pathological conditions. The hallmark of preeclampsia is endothelial dysfunction induced by systemic inflammation, in which neutrophils, particularly through the formation of neutrophil extracellular traps (NETs), play a pivotal role in the development and perpetuation of endothelial dysfunction and the hypertensive state. Considering the potential of numerous pharmaceutical agents to attenuate NET formation (NETosis) in preeclampsia, a comprehensive assessment of the extensively studied candidates becomes imperative. This review aims to identify mechanisms associated with the induction and negative regulation of NETs in the context of preeclampsia. We discuss potential drugs to modulate NETosis, such as NF-κβ inhibitors, vitamin D, and aspirin, and their association with mutagenicity and genotoxicity. Strong evidence supports the notion that molecules involved in the activation of NETs could serve as promising targets for the treatment of preeclampsia.

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Endothelial progenitor cells in pregnancy-related diseases

Chen,

Wan,

et al. 2023

Clinical Science

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Placental neovascularization plays a crucial role in fetomaternal circulation throughout pregnancy and is dysregulated in several pregnancy-related diseases, including preeclampsia, gestational diabetes mellitus, and fetal growth restriction. Endothelial progenitor cells (EPCs) are a heterogeneous population of cells that differentiate into mature endothelial cells, which influence vascular homeostasis, neovascularization, and endothelial repair. Since their discovery in 1997 by Asahara et al., the role of EPCs in vascular biology has garnered a lot of interest. However, although pregnancy-related conditions are associated with changes in the number and function of EPCs, the reported findings are conflicting. This review discusses the discovery, isolation, and classification of EPCs and highlights discrepancies between current studies. Overviews of how various diseases affect the numbers and functions of EPCs, the role of EPCs as biomarkers of pregnancy disorders, and the potential therapeutic applications involving EPCs are also provided.

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Impact of P-selectin–PSGL-1 Axis on Platelet-Endothelium-Leukocyte Interactions in Fatal COVID-19

Cited by 4 publications

References 71 publications

Targeting IL-6 trans-signalling by sgp130Fc attenuates severity in SARS-CoV-2 -infected mice and reduces endotheliopathy

Targeting IL-6 trans-signalling by sgp130Fc attenuates severity in SARS-CoV-2 -infected mice and reduces endotheliopathy

Targeting Neutrophil Extracellular Trap Formation: Exploring Promising Pharmacological Strategies for the Treatment of Preeclampsia

Endothelial progenitor cells in pregnancy-related diseases

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