Impact of p53-associated acute myeloid leukemia hallmarks on metabolism and the immune environment
Monika Chomczyk,
Luca Gazzola,
Shubhankar Dash
et al.
Abstract:Acute myeloid leukemia (AML), an aggressive malignancy of hematopoietic stem cells, is characterized by the blockade of cell differentiation, uncontrolled proliferation, and cell expansion that impairs healthy hematopoiesis and results in pancytopenia and susceptibility to infections. Several genetic and chromosomal aberrations play a role in AML and influence patient outcomes. TP53 is a key tumor suppressor gene involved in a variety of cell features, such as cell-cycle regulation, genome stability, prolifera… Show more
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