Impact of Package and Storage Techniques on Kidney Temperature Enviroment

Oliveira, Gabriela Yale L.; Cunha, Luã S.; Santos, Alessandro Corrêa Prudente dos; Caetano, Luisa Maria M.; Soares, Yuri S.; Mota, Laila Gabriely S.; Sobrinho, Diego Henrique Gomes

doi:10.1097/01.tp.0000525112.18751.da

Cited by 4 publications

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“…Conversely, if the temperature falls below the required range, there is a risk of cold injury to the organ [30]. Additionally, maintaining an optimal humidity level within the organ container is also crucial [31]. Utilizing IoT-enabled sensor technology can effectively address a significant concern in organ transportation, specifically the risk of organ contamination during the transfer process from the donor to the recipient [26][27][28][29].…”

Section: Objective Of the Studymentioning

confidence: 99%

A Decentralized Application for Managing Organ Donation, Transportation, and Transplantation Processes through Blockchain, Smart Contracts, and Internet of Things Integration

Bawa,

Singh

2024

Preprint

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Currently organ donation and transplantation management systems are designed using either centralized architecture or decentralized architecture. The centralized architectures lack transparency for the stakeholders thereby causing unethical allocation of organs and unauthorized alterations to organ waiting lists. Additionally, centralized models are susceptible to data vulnerability through third-party interference, ultimately eroding trust in the system. On the other hand, the existing blockchain-based decentralized models suffer from high Ether consumption during deployment. Furthermore, both models fail to provide stakeholders with access to vital information regarding the condition of organs during their transportation from the donor to the recipient. This includes factors like temperature, humidity level, and light exposure inside the organ container, and orientation and vibration of the container. This absence of supervision increases the risk of contamination of organs during transit, highlighting a crucial gap in safe organ transportation. The paper presents a decentralized application powered by blockchain and Internet of Things technologies for managing stakeholder registration, efficient patient-donor matching, organ retrieval, transportation, and transplantation. The proposed application ensures complete data security, process transparency, and a trustful environment for stakeholders. Furthermore, the application ensures safe organ transportation and a reduction in the risk of organ contamination. A comparative analysis with existing blockchain-based organ management applications has been presented. Notable improvements in Ether consumption with a deployment cost of approximately 0.00582850 Ether, reduced gas utilization of 446104.333 units, process transparency, organ monitoring, and the assurance of safe transportation within the proposed application have been observed.

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Section: Objective Of the Studymentioning

confidence: 99%

A Decentralized Application for Managing Organ Donation, Transportation, and Transplantation Processes through Blockchain, Smart Contracts, and Internet of Things Integration

Bawa,

Singh

2024

Preprint

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“…Hypothermia, however, can also have deleterious effects on cells, including the maladaptive redistribution of membrane lipids and subsequent loss of membrane integrity 6 . Hypothermic cooling, then, is a delicate balancing act between the beneficial and detrimental effects of cooling, with the temperature at which damaging effects are minimized and protective effects maximized around 4°C 7,8 …”

Section: Introductionmentioning

confidence: 99%

Machine perfusion of donor organs for transplantation

et al. 2021

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The ever‐widening gap between organ supply and demand has resulted in an organ shortage crisis that affects patients all over the world. For decades, static cold storage (SCS) was the gold standard preservation strategy because of its simplicity and cost‐effectiveness, but the rising unmet demand for donor organ transplants has prompted investigation into preservation strategies that can expand the available donor pool. Through ex vivo functional assessment of the organ prior to transplant, newer methods to preserve organs such as perfusion‐based therapy can potentially expand the available organ pool. This review will explain the physiologic rationale for SCS before exploring the advantages and disadvantages associated with the two broad classes of preservation strategies that have emerged to address the crisis: hypothermic and normothermic machine perfusion. A detailed analysis of how each preservation strategy works will be provided before investigating the current status of clinical data for each preservation strategy for the kidney, liver, pancreas, heart, and lung. For some organs there is robust data to support the use of machine perfusion technologies over SCS, and in others the data are less clear. Nonetheless, machine perfusion technologies represent an exciting frontier in organ preservation research and will remain a crucial component of closing the gap between organ supply and recipient demand.

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Exploring Perspectives of Blockchain Technology and Traditional Centralized Technology in Organ Donation Management: A Comprehensive Review

Bawa,

Singh,

Rani

et al. 2024

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Background/Objectives: The healthcare sector is rapidly growing, aiming to promote health, provide treatment, and enhance well-being. This paper focuses on the organ donation and transplantation system, a vital aspect of healthcare. It offers a comprehensive review of challenges in global organ donation and transplantation, highlighting issues of fairness and transparency, and compares centralized architecture-based models and blockchain-based decentralized models. Methods: This work reviews 370 publications from 2016 to 2023 on organ donation management systems. Out of these, 85 publications met the inclusion criteria, including 67 journal articles, 2 doctoral theses, and 16 conference papers. About 50.6% of these publications focus on global challenges in the system. Additionally, 12.9% of the publications examine centralized architecture-based models, and 36.5% of the publications explore blockchain-based decentralized models. Results: Concerns about organ trafficking, illicit trade, system distrust, and unethical allocation are highlighted, with a lack of transparency as the primary catalyst in organ donation and transplantation. It has been observed that centralized architecture-based models use technologies such as Python, Java, SQL, and Android Technology but face data storage issues. In contrast, blockchain-based decentralized models, mainly using Ethereum and a subset on Hyperledger Fabric, benefit from decentralized data storage, ensure transparency, and address these concerns efficiently. Conclusions: It has been observed that blockchain technology-based models are the better option for organ donation management systems. Further, suggestions for future directions for researchers in the field of organ donation management systems have been presented.

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Impact of Package and Storage Techniques on Kidney Temperature Enviroment

Cited by 4 publications

References 0 publications

A Decentralized Application for Managing Organ Donation, Transportation, and Transplantation Processes through Blockchain, Smart Contracts, and Internet of Things Integration

A Decentralized Application for Managing Organ Donation, Transportation, and Transplantation Processes through Blockchain, Smart Contracts, and Internet of Things Integration

Machine perfusion of donor organs for transplantation

Exploring Perspectives of Blockchain Technology and Traditional Centralized Technology in Organ Donation Management: A Comprehensive Review

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