Impact of PAI-1 4G/5G and C &gt; G polymorphisms in acute ST elevation myocardial infarction and stable angina patients: A single center Egyptian study

Al-Wakeel, Hanan; Sewelam, Nadia; Khaled, Mohamed; Abdelbary, Akram

doi:10.1016/j.ejmhg.2018.05.003

Cited by 1 publication

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“…Nikolopoulos and coworkers in a meta-analysis demonstrated that the 4G allele is associated with a slightly increased risk of MI [ 44 ]. In the current study, and contrary to the latter meta-analysis, but similar to studies from Egyptian, young Italian and Finnish patients, the 4G allele was not associated with such an increased risk [ 7 , 45 , 46 ].…”

Section: Resultscontrasting

confidence: 79%

Genetic polymorphisms in early-onset myocardial infarction in a sample of Iraqi patients: a pilot study

et al. 2020

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Objectives Early-onset myocardial infarction constitutes nearly one third of cases of myocardial infarction among Iraqis, which is rather higher than the proportions reported in many Western countries. Thus this study was initiated to investigate the role of some genetic polymorphisms, as well as acquired risk factors in this condition. Results A total of 102 Iraqi patients with first myocardial infarction aged 50 years, and 77 matched controls were enrolled. The DNAs of participants were screened for nine polymorphisms, namely: β-Fibrinogen (− 455G > A), Factor XIII (V34L), Plasminogen Activator inhibitor-1 (PAI-1, 4G/5G), Human Platelet Antigen-1 (HPA1a/b), 5,10-Methylenetetrahydrofolate Reductase MTHFR (C677T) and MTHFR (A1298C), Angiotensin-Converting Enzyme (ACE) 287 bp insertion/deletion (I/D), Apolipoprotein-B (ApoB: R3500Q), and Apolipoprotein-E (Apo E: E2/E3/E4), using PCR and reverse hybridization technique. Among traditional risk factors, univariate analysis revealed that smoking (OR 2.86 [95%CI 1.53–5.34]), hyperlipidemia (OR 5.23 [95%CI 2.66–10.29]), and diabetes mellitus (OR 4.05 [95% CI 1.57–10.41]) were significantly higher among patients compared to controls (P<0.001, <0.001 and 0.002 respectively), while none of the nine genetic polymorphisms reached significance. Multivariate Logistic regression, however, revealed that only smoking and hyperlipidemia retained significance (P of < 0.001 each). The need to initiate further studies on larger cohorts is paramount to understand the higher than expected frequency of early-onset myocardial infarction in our population.

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Section: Resultscontrasting

confidence: 79%

Genetic polymorphisms in early-onset myocardial infarction in a sample of Iraqi patients: a pilot study

et al. 2020

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Impact of PAI-1 4G/5G and C > G polymorphisms in acute ST elevation myocardial infarction and stable angina patients: A single center Egyptian study

Cited by 1 publication

References 38 publications

Genetic polymorphisms in early-onset myocardial infarction in a sample of Iraqi patients: a pilot study

Genetic polymorphisms in early-onset myocardial infarction in a sample of Iraqi patients: a pilot study

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Impact of PAI-1 4G/5G and C > G polymorphisms in acute ST elevation myocardial infarction and stable angina patients: A single center Egyptian study

Cited by 1 publication

References 38 publications

Genetic polymorphisms in early-onset myocardial infarction in a sample of Iraqi patients: a pilot study

Genetic polymorphisms in early-onset myocardial infarction in a sample of Iraqi patients: a pilot study

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Impact of PAI-1 4G/5G and C > G polymorphisms in acute ST elevation myocardial infarction and stable angina patients: A single center Egyptian study