Impact of PARP-1 and DNA-PK expression on survival in patients with glioblastoma multiforme

Kase, Marju; Vardja, M.; Lipping, Agu; Asser, Toomas; Jaal, Jana

doi:10.1016/j.radonc.2011.06.024

Cited by 29 publications

(14 citation statements)

References 41 publications

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“…Our study is consistent with the recently reported positive correlation between PARP1 protein expression and response to neoadjuvant chemotherapy Von et al, 2010). Moreover, ADPRT polymorphism is reported to have a significant association with the prognosis of various human cancers, such as ovarian cancer, lung cancer and glioma (Nowsheen et al, 2011;Kase et al, 2011;Wysham et al, 2012). Further larger studies are needed to validate the association between ADPRT Val762Ala polymorphism and breat cancer prognosis.…”

Section: Discussionsupporting

confidence: 92%

XRCC1 and ADPRT Polymorphisms Associated with Survival in Breast Cancer Cases Treated with Chemotherapy

Rong¹,

Huang²,

Zheng³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 92%

XRCC1 and ADPRT Polymorphisms Associated with Survival in Breast Cancer Cases Treated with Chemotherapy

Rong¹,

Huang²,

Zheng³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…This observation suggests that PARP-1 may play a role in this tumor and that the presence of the protein may be used as a cell marker. Indeed, previous studies 13,14 found the expression of PARP-1 in brain whit GBM, in normal brain and in nucleus and cytoplasm of human neurons, also Wharton et al 2000 15 have observed expression of PARP-1 in multicellular tumour spheroids, derived from human glioma cell lines.…”

Section: Discussionmentioning

confidence: 86%

PARP-1 protein expression in glioblastoma multiforme

Galia¹,

Calogero²,

Condorelli³

et al. 2012

Eur J Histochem

121

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One of the most common type of primary brain tumors in adults is the glioblastoma multiforme (GBM) (World Health Organization grade IV astrocytoma). It is the most common malignant and aggressive form of glioma and it is among the most lethal ones. Poly (ADP-ribose) polymerase 1 (PARP-1) gene, located to 1q42, plays an important role for the efficient maintenance of genome integrity. PARP-1 protein is required for the apoptosis-inducing factor (AIF) translocation from the mitochondria to the nucleus. PARP-1 is proteolytically cleaved at the onset of apoptosis by caspase-3. Microarray analysis of PARP-1 gene expression in more than 8000 samples revealed that PARP-1 is more highly expressed in several types of cancer compared with the equivalent normal tissues. Overall, the most differences in PARP-1 gene expression have been observed in breast, ovarian, endometrial, lung, and skin cancers, and non-Hodgkin's lymphoma. We evaluated the expression of PARP-1 protein in normal brain tissues and primary GBM by immunohistochemistry. Positive nuclear PARP-1 staining was found in all samples with GBM, but not in normal neurons from controls (n=4) and GBM patients (n=27). No cytoplasmic staining was observed in any sample. In conclusion, PARP-1 gene is expressed in GBM. This finding may be envisioned as an attempt to trigger apoptosis in this tumor, as well as in many other malignancies. The presence of the protein exclusively at the nucleus further support the function played by this gene in genome integrity maintenance and apoptosis. Finally, PARP-1 staining may be used as GBM cell marker.

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“…The role of PARP1 has been described in other tumours such as breast [51], ovarian [6], pancreatic carcinomas [24], gastric carcinomas [62], prostate carcinomas [53], melanomas [13,40] and glioblastomas [12,21] but has not been investigated in meningiomas yet.…”

Section: Introductionmentioning

confidence: 99%

Original article Poly(ADP-ribose) polymerase-1 (PARP1) and p53 labelling index correlates with tumour grade in meningiomas

Csonka¹,

Murnyák²,

Szepesi³

et al. 2014

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Impact of PARP-1 and DNA-PK expression on survival in patients with glioblastoma multiforme

Cited by 29 publications

References 41 publications

XRCC1 and ADPRT Polymorphisms Associated with Survival in Breast Cancer Cases Treated with Chemotherapy

XRCC1 and ADPRT Polymorphisms Associated with Survival in Breast Cancer Cases Treated with Chemotherapy

PARP-1 protein expression in glioblastoma multiforme

Original article Poly(ADP-ribose) polymerase-1 (PARP1) and p53 labelling index correlates with tumour grade in meningiomas

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