Impact of particulate deproteinized bovine bone mineral and porous titanium granules on early stability and osseointegration of dental implants in narrow marginal circumferential bone defects

Abstract

The use of two particulate bone graft substitute materials in experimental narrow marginal peri-implant bone defects was investigated with respect to early bone healing and implant stability. Porous titanium granules, oxidized white porous titanium granules (WPTG), and demineralized bovine bone mineral (DBBM) were characterized in vitro, after which the two latter materials were tested in experimental peri-implant bone defects in six minipigs, with empty defects as control. After mandibular premolar extraction, the top 5mm of the alveoli were widened to 6mm in diameter, followed by the placement of six implants, three on each side, in each pig. Six weeks of healing was allowed. The WPTG showed better mechanical properties. No significant differences in resonance frequency analysis were found directly after compacting or healing, and similar quantities of defect bone formation were observed on micro-computed tomography for all groups. Histomorphometric analysis demonstrated a more coronal bone-to-implant contact in the DBBM group, which also displayed more defect bone fill as compared to the WPTG group. The better mechanical properties observed for WPTG appear of negligible relevance for the early stability and osseointegration of implants.

The chemical surface evaluation of black and white porous titanium granules and different commercial dental implants with energy‐dispersive x‐ray spectroscopy analysis

“…In our study, no oxygen element was detected on the surface of the PTG granules; by contrast, the WPTG surface had TiO 2 molecules. Experimental research has shown that WPTG yields better osseointegration results compared with PTG . Nonoxidized PTG may have an adverse effect on osseointegration.…”

“…molecules. Experimental research has shown that WPTG yields better osseointegration results compared with PTG 41. Nonoxidized PTG may have an adverse effect on osseointegration.…”

Porous Titanium Granules in comparison with Autogenous Bone Graft in Femoral Osseous Defects: A Histomorphometric Study of Bone Regeneration and Osseointegration in Rabbits

“…ere is increasing demand for alloplastic graft materials in Implant Dentistry. Porous titanium granules (PTGs) are a biocompatible, nonresorbable alloplastic graft material with osteoconductive properties [2][3][4][5][6][7][8][9][10][11].…”

“…Porous titanium granules were first used in Orthopedics [2,3] and then began to be applied in Dentistry [4,13,14]. Porous titanium granules have been studied in postextraction sockets [7,[15][16][17], maxillary sinus augmentation [4,6,[18][19][20][21], peri-implant defects [9,10,[22][23][24][25][26], supracrestal vertical bone augmentation [27], and periodontal defects [23,28]. ey have been studied in various animal models, such as rabbits [5,6,8,27], dogs [3,7,9,15,16], sheep [11], and mini-pigs [10,17,28], and humans as well [4, 13, 14, 18, 19, 21-26, 29, 30].…”

“…PTG has been studied alone or in combination with xenograft [20]. Porous titanium granules have been compared to demineralized bovine bone mineral (DBBM) in animals [9,10,28], to bovine hydroxyapatite in animals [6], and to deproteinized bovine particulates (Bio-Oss) in humans [19]. Comparisons between PTG (or WPTG) and autogenous osseous graft, which is the clinical gold standard, have not been published yet.…”