Impact of passive heat acclimation on markers of kidney function during heat stress

Ravanelli, Nicholas; Barry, Hadiatou; Schlader, Zachary J.; Gagnon, Daniel

doi:10.1113/ep088637

Cited by 23 publications

(19 citation statements)

References 66 publications

(126 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1), does not necessarily support this within our cohort. Although some classical HA adaptations were evident after E EX and E HWI , further heat/ exercise stimulus maybe required to develop greater magnitudes of adaptation and develop significant adaptation in other pertinent heat illness markers such as renal function 25 and gut-permeability. 26 Future work should investigate these variables, alongside cellular/molecular responses including heat shock proteins (HSPs) given the importance of HSPs in heat adaptation, 27 and age-related declines in HSP inducibility.…”

Section: Discussionmentioning

confidence: 99%

Exercise heat acclimation and post-exercise hot water immersion improve resting and exercise responses to heat stress in the elderly

Waldock

Gibson

Relf

et al. 2021

Journal of Science and Medicine in Sport

View full text Add to dashboard Cite

Objectives: To investigate the efficacy of heat acclimation (HA) in the young (Y EX ) and elderly (E EX ) following exercise-HA, and the elderly utilising post-exercise hot water immersion HA (E HWI ). Design: Cross-sectional study. Method: Twenty-six participants (Y EX : n = 11 aged 22 ± 2 years, E EX: n = 8 aged 68 ± 3 years, E HWI : n = 7 aged 73 ± 3 years) completed two pre-/post-tests, separated by five intervention days. Y EX and E EX exercised in hot conditions to raise rectal temperature (T rec ) ≥38.5°C within 60 min, with this increase maintained for a further 60 min. E HWI completed 30 min of cycling in temperate conditions, then 30 min of HWI (40°C), followed by 30 min seated blanket wrap. Pre-and post-testing comprised 30 min rest, followed by 30 min of cycling exercise (3.5 W•kg −1 Ḣ prod), and a six-minute walk test (6MWT), all in 35°C, 50% RH. Results: The HA protocols did not elicit different mean heart rate (HR), T rec , and duration T rec ≥ 38.5°C (p > 0.05) between Y EX , E EX , and E HWI groups. Resting T rec , peak skin temperature, systolic and mean arterial pressure, perceived exertion and thermal sensation decreased, and 6MWT distance increased pre-to post-HA (p < 0.05), with no difference between groups. Y EX also demonstrated a reduction in resting HR (p < 0.05). No change was observed in peak T rec or HR, vascular conductance, sweat rate, or thermal comfort in any group (p > 0.05). Conclusions: Irrespective of age or intervention, HA induced thermoregulatory, perceptual and exercise performance improvements. Both exercise-HA (E EX ), and post-exercise HWI (E HWI ) are considered viable interventions to prepare the elderly for heat stress.

show abstract

Section: Discussionmentioning

confidence: 99%

Exercise heat acclimation and post-exercise hot water immersion improve resting and exercise responses to heat stress in the elderly

Waldock

Gibson

Relf

et al. 2021

Journal of Science and Medicine in Sport

View full text Add to dashboard Cite

show abstract

“…The notion that O 2peak,kg would affect HA responsiveness rests on the assumption that O 2peak,kg represents partial adaptation status (Taylor and Cotter 2006 ; Ravanelli et al 2020 ). However, this assumption may lack validity, given the variability in O 2peak,kg trainability (Bouchard et al 2011 ) and exercise environment (e.g., water vs. land; Avellini et al 1982 ) or modality (e.g., sprinters vs. endurance athletes; Amano et al 2013 ).…”

Section: Discussionmentioning

confidence: 99%

“…It should be noted that O 2peak,kg does not directly relate to the exercise-induced partial heat adaptation status. Researchers have proposed that habitual training activity might be more reflective of this partial adaptation status (Lamarche et al 2018a ; Ravanelli et al 2020 ). Altogether, there is no consensus on the degree to which fit and unfit individuals benefit from HA.…”

Section: Introductionmentioning

confidence: 99%

Individual characteristics associated with the magnitude of heat acclimation adaptations

Alkemade

Gerrett

Eijsvogels³

et al. 2021

Eur J Appl Physiol

View full text Add to dashboard Cite

Purpose The magnitude of heat acclimation (HA) adaptations varies largely among individuals, but it remains unclear what factors influence this variability. This study compared individual characteristics related to fitness status and body dimensions of low-, medium-, and high responders to HA. Methods Twenty-four participants (9 female, 15 male; maximum oxygen uptake [$$\dot{{V}}$$ V ˙ O2peak,kg] 52 ± 9 mL kg−1 min−1) completed 10 daily controlled-hyperthermia HA sessions. Adaptations were evaluated by heat stress tests (HST; 35 min cycling 1.5 W kg−1; 33 °C, 65% relative humidity) pre- and post-HA. Low-, medium-, and high responder groups were determined based on tertiles (n = 8) of individual adaptations for resting rectal temperature (Tre), exercise-induced Tre rise (ΔTre), whole-body sweat rate (WBSR), and heart rate (HR). Results Body dimensions (p > 0.3) and $$\dot{{V}}$$ V ˙ O2peak,kg (p > 0.052) did not differentiate low-, medium-, and high responders for resting Tre or ΔTre. High WBSR responders had a larger body mass and lower body surface area-to-mass ratio than low responders (83.0 ± 9.3 vs 67.5 ± 7.3 kg; 249 ± 12 vs 274 ± 15 cm2 kg−1, respectively; p < 0.005). Conversely, high HR responders had a smaller body mass than low responders (69.2 ± 6.8 vs 83.4 ± 9.4 kg; p = 0.02). $$\dot{{V}}$$ V ˙ O2peak,kg did not differ among levels of responsiveness for WBSR and HR (p > 0.3). Conclusion Individual body dimensions influenced the magnitude of sudomotor and cardiovascular adaptive responses, but did not differentiate Tre adaptations to HA. The influence of $$\dot{{V}}$$ V ˙ O2peak,kg on the magnitude of adaptations was limited.

show abstract

“…Furthermore, oxidative stress caused by HS has been shown to damage mitochondria, cell membrane and protein, and consequently affect the liver lipid metabolism and animal production performance ( 9 ). In addition, HS affects the glomerular filtration and urine concentration function of the kidneys by inducing changes in the levels of body electrolytes, especially the balance of sodium, potassium, calcium, and chloride ions, and creatinine metabolism ( 15 , 16 ).…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Analysis of the Colonic Flora Diversity, Short Chain Fatty Acid Metabolism, Transcripts, and Biochemical Indexes in Heat-Stressed Pigs

Niu

Wen

et al. 2021

Front. Immunol.

View full text Add to dashboard Cite

Heat stressed pigs show typical characteristics of inflammatory bowel disease (IBD). However, little is known about the pathogenesis of heat stress (HS)-induced IBD in pigs. In this study, we determined the effects of HS on colon morphology, intestinal microbiota diversity, transcriptome genes (transcripts), and short chain fatty acids (SCFAs) metabolism in pigs. In addition, the correlation among these parameters was analyzed by weighted gene co-expression network analysis. Results showed that the liver and kidney functions related to blood biochemical indexes were partially changed in pigs under HS. Furthermore, the levels of diamine oxidase and D-lactic acid were significantly increased, whereas the levels of secretory immunoglobulin A were decreased. The integrity of colonic tissue was damaged under HS, as bleeding, lymphatic infiltration, and villi injury were observed. The concentrations of SCFAs in the colon, such as acetic acid and butyric acid, were decreased significantly. In addition, the composition of colon microbiota, such as decrease in Lactobacillus johnsonii, Lactobacillus reuteri and increase in Clostridium sensu stricto 1 of day 7 and 14 while under HS. These changes were associated with changes in the concentration of SCFAs and biochemical indexes above mentioned. Differentially expressed genes were enriched in the nucleotide-binding oligomerization domain-like receptor signaling pathway, Th17 cell differentiation, and IBD pathway, which were also associated with the changes in SCFAs. Thus, the structure, diversity of intestinal microorganisms, and changes in the levels of SCFAs in colon of heat stressed pigs changed significantly, contributing to the activation of immune response and inflammatory signal pathways and causing abnormal physiological and biochemical indexes and intestinal mucosal damage. These results highlight the interconnections between intestinal microbiota, SCFAs, and immune response and their role in the pathogenesis of stress induced IBD therapy.

show abstract

Impact of passive heat acclimation on markers of kidney function during heat stress

Cited by 23 publications

References 66 publications

Exercise heat acclimation and post-exercise hot water immersion improve resting and exercise responses to heat stress in the elderly

Exercise heat acclimation and post-exercise hot water immersion improve resting and exercise responses to heat stress in the elderly

Individual characteristics associated with the magnitude of heat acclimation adaptations

A Comprehensive Analysis of the Colonic Flora Diversity, Short Chain Fatty Acid Metabolism, Transcripts, and Biochemical Indexes in Heat-Stressed Pigs

Contact Info

Product

Resources

About