2010
DOI: 10.1016/j.jhep.2009.12.028
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Impact of peginterferon and ribavirin therapy on hepatocellular carcinoma: Incidence and survival in hepatitis C patients with advanced fibrosis

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Cited by 305 publications
(240 citation statements)
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“…This would not have been the case if we had considered HCC or decompensation, which may be subject to interval censoring and, in addition, to a bias of diagnosis. Moreover, a previous analysis of the same cohort found that SVR patients had significantly lower chances of HCC and liver complications than non-SVR patients (22). Consistent with this finding, results from the HALT-C trial showed a lower incidence of HCC in patients randomized to long-term, low-dose pegylated interferon; however, the difference emerged only after 5 to 7 years of follow-up (23).…”
Section: Discussionsupporting
confidence: 64%
“…This would not have been the case if we had considered HCC or decompensation, which may be subject to interval censoring and, in addition, to a bias of diagnosis. Moreover, a previous analysis of the same cohort found that SVR patients had significantly lower chances of HCC and liver complications than non-SVR patients (22). Consistent with this finding, results from the HALT-C trial showed a lower incidence of HCC in patients randomized to long-term, low-dose pegylated interferon; however, the difference emerged only after 5 to 7 years of follow-up (23).…”
Section: Discussionsupporting
confidence: 64%
“…Although several clinical studies have demonstrated that eradication of HCV with IFN-based regimens results in the suppression of liver carcinogenesis [49][50][51], HCC can still develop after viral eradication. Indeed, the 5-year HCC incidence after SVR by IFN-based antiviral therapy for HCV-related chronic liver disease is 2.3-8.8 % [52].…”
Section: Introductionmentioning
confidence: 99%
“…Elimination of HCV resulted in a decrease of 5-year-mortality by 62-84%; the risk for development of HCC was lowered by 68-79%; the risk for liver transplantation was lowered by 90% [38]. A post hoc analysis of the HALT-C trial confirmed two prior large retrospective follow-up studies from Italy and France in which the incidence of HCC among patients with SVR was significantly lower compared to those without SVR [39][40][41]. Morgan et al [42] described a similar HCC risk reduction with SVR among patients with all stages of fibrosis (HR 0.24) with a separate analysis, although predominantly including studies from Asia where the risk of HCC is substantially higher.…”
Section: Hepatocellular Carcinoma and Daas: A Controversial Storymentioning
confidence: 75%