Impact of perinatal different intrauterine environments on child growth and development in the first six months of life - IVAPSA birth cohort: rationale, design, and methods

Abstract

BackgroundIn the last twenty years, retrospective studies have shown that perinatal events may impact the individual health in the medium and long term. However, only a few prospective studies were designed to address this phenomenon. This study aims to describe the design and methods of the Impact of Perinatal Environmental Variations in the First Six Months of Life - the IVAPSA Birth Cohort.Method/DesignThis is a clinical study and involves the recruitment of a birth cohort from hospitals in Porto Alegre, Rio Grande do Sul, Brazil. Mothers from different clinical backgrounds (hypertensive, diabetics, smokers, having an intrauterine growth restricted child for idiopathic reasons, and controls) will be invited to join the study twenty-four hours after the birth of their child. Data on economic, social, and maternal health care, feeding practices, anthropometric measures, physical activity, and neuropsychological evaluation will be obtained in interviews at postpartum, 7 and 15 days, 1, 3 and 6 months of life.DiscussionTo our knowledge, this is the first thematic cohort focused on the effects of intrauterine growth restriction to prospectively enroll mothers from different clinical backgrounds. The IVAPSA Birth Cohort is a promising research platform that can contribute to the knowledge on the relationship between perinatal events and their consequences on the children's early life.

Postnatal Anthropometric and Body Composition Profiles in Infants with Intrauterine Growth Restriction Identified by Prenatal Doppler

“…Differentiating SGA infants, marked by constitutional smallness, from IUGR births often presents a diagnostic challenge. However, it is important to do so, given the increased risk of perinatal morbidity and mortality attached to IUGR, as well as the long-term metabolic, cardiovascular, and neurologic consequences of fetal programming in utero [ 24 – 31 ].…”

The weight gain influence of pregnant women under different clinical conditions on weight at the birth of newborns.

“…The study design and methods have been published elsewhere. 16 And, more recently, its development and data collection processing. 17 A convenience sample consisting of 400 mother-child pairs was recruited.…”

“…HIV-positive women, those with multiple pregnancies or premature births (<37 weeks), as well as newborns with acute illnesses or congenital malformations were not included in the study. The selection criteria for inclusion in the study groups, recruitment, and interviews are described in detail in the original article by Bernardi et al 16 The IVAPSA cohort recruited 400 mother-child pairs, each allocated into one of ve health condition groups. Twenty-eight mother-child pairs meeting the criteria for more than one group concomitantly were characterized as a "multiple criterion group" and were excluded from the study.…”

Relação entre a retenção de peso nos primeiros três meses pós-parto com ganho de peso e ingestão alimentar durante a gestação

“…Trata-se de um estudo de coorte, parte de um estudo maior prospectivo controlado intitulado "Impacto das Variações do Ambiente Perinatal sobre a Saúde do Recém-Nascido nos Primeiros Seis Meses de Vida" (IVAPSA) com início em setembro de 2011 que tem por objetivo principal descrever o impacto das variações no ambiente perinatal nos primeiros seis meses de vida do recém-nascido. 12 O recrutamento das participantes ocorreu no Hospital de Clínicas de Porto Alegre (HCPA) e no Grupo Hospitalar Conceição (GHC). A amostra foi selecionada de maneira consecutiva.…”