Impact of Periodontal Inflammation on Nutrition and Inflammation Markers in Hemodialysis Patients

Abstract

Background: Malnutrition-inflammation complex syndrome (MICS) is a common and usually concurrent condition occurring in patients undergoing hemodialysis (HD), with a pathogenesis linked to biological and in situ environmental traditional risk factors. Periodontitis, one of the major types of infection-driven inflammation, often co-occurs in the in the hemodialysis population and correlates with markers of malnutrition and inflammation, such as albumin, creatinine, and C-reactive protein. Aim: The present study aimed to determine whether the periodontal inflammatory status parameters correlate with the albumin, creatinine, and C-reactive protein serum concentrations in HD patients, and investigate whether periodontal treatment improves these markers of nutritional and systemic inflammation. Materials and Methods: The serum creatinine, albumin, and C-reactive Protein (CRP) levels were measured at baseline and after non-surgical periodontal treatment, at 3 months and 6 months. Results: At 3 months, a significant correlation between plaque index and C-reactive protein (p = 0.012), bleeding on probing and C-reactive protein (p < 0.0019), and clinical attachment level and C-reactive protein (p = 0.022) was found. No significant correlation was found between clinical periodontal parameters and nutrition markers at each time. Conclusions: Our results confirmed the association between C-reactive protein serum concentration and periodontal inflammatory status, but further research is necessary to identify the contributing role of periodontitis on the onset and progression of MICS.

Effect of periodontal treatment on the glomerular filtration rate, reduction of inflammatory markers and mortality in patients with chronic kidney disease: A systematic review

“…A total of 257 records were rejected because they did not meet the inclusion criteria. The remaining 20 underwent full text examination: one article did not meet the inclusion criteria (publication of a future study protocol) [ 23 ] and one article was a short communication [ 24 ]; 18 studies were finally included ( Fig 1 ) [ 25 – 42 ].…”

The Association Between Self-Management Ability and Malnutrition-Inflammation-Atherosclerosis Syndrome in Peritoneal Dialysis Patients: A Cross-Sectional Study

“…Furthermore, the in ammation indictors, such as IL-6, were lower in this group. Chronic in ammatory states are commonly found in patients with end-stage renal disease [25], and in ammatory cytokines, including IL-6, IL-1, TNF-a and CRP play an important role [7]. Notably, here, in ammation refers to an increase in pro-in ammatory factors rather than infection caused by microorganisms [26].…”

The association between self-management ability and malnutrition-inflammation-atherosclerosis syndrome in peritoneal dialysis patients: a cross-sectional study

“…Furthermore, the inflammation indictors, such as IL-6, were lower in this group. Chronic inflammatory states are commonly found in patients with end-stage renal disease [ 25 ], and inflammatory cytokines, including IL-6, IL-1, TNF-a and CRP play an important role [ 7 ]. Notably, here, inflammation refers to an increase in pro-inflammatory factors rather than infection caused by microorganisms [ 26 ].…”