Impact of Periodontitis on Glycemic Control and Metabolic Status in Diabetes Patients: Current Knowledge on Early Disease Markers and Therapeutic Perspectives

Santonocito, Simona; Polizzi, Alessandro; Marchetti, Enrico; Dalessandri, Domenico; Migliorati, Marco; Lupi, Saturnino Marco; Cicciù, Marco; Isola, Gaetano

doi:10.1155/2022/4955277

Cited by 13 publications

(20 citation statements)

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“…This combination does not foretell the best outcomes for oral health, and it is likely/will likely be associated with a high edentulism experience [ 2 , 20 , 21 , 24 ]. In the present study, T2DM was a risk factor for edentulism as reported in other studies [ 8 , 9 , 21 , 34 , 36 ]. In recent years, the connection between oral health and systemic health has been widely recognized by the dental and medical professions.…”

Section: Discussionsupporting

confidence: 88%

“…The bidirectional link between diabetes and periodontitis has been well established: through various mechanisms, diabetes promotes the destruction of periodontal tissues and periodontal disease negatively affects glycemic control [ 34 ]. The prevalence of edentulism in patients with T2DM is associated with oral problems such as salivary gland hypofunction, periodontitis, root caries, and pulpal involvement after severe carious lesions, as well as being associated with general health factors such as depression, cognitive impairment, and pain [ 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

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Comparative Analysis of Edentulism in a Sample of Mexican Adults with and without Type 2 Diabetes

et al. 2022

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The objective of the present study was to compare the prevalence of edentulism in Mexican adults with and without a diagnosis of type 2 diabetes mellitus (T2DM) when they are seeking dental care. A cross-sectional study was conducted on 1921 medical records of Mexican adults 40 years of age and older who sought dental care at clinics of a public university in Mexico. The dependent variable was edentulism, clinically determined through an oral examination. The main independent variable was the self-report of previous T2DM diagnosis made by a physician. Sociodemographic, socioeconomic and behavioral covariates were included in a multivariate binary logistic regression model. Overall edentulism prevalence was 8.4% (95% CI = 7.1–9.6). The prevalence of T2DM was 14.3% (n = 274). The prevalence of edentulism among individuals with T2DM was 13.1%, but only 7.6% among individuals without T2DM. In the multivariate binary logistic regression model, a previous T2DM diagnosis increased the probability of being edentulous 1.61 times (95% CI = 1.03–2.50). For each year a person’s age increased, the likelihood of being edentulous increased by 12% (95% CI = 10–14%). In summary, a higher prevalence of edentulism was present in Mexican adults with T2DM and in those of older age. This information may be used by dental care providers and health policymakers to improve approaches to preventive care, as well as to characterize and anticipate care needs more accurately for the adult and older adult populations.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Edentulism in a Sample of Mexican Adults with and without Type 2 Diabetes

et al. 2022

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“…Moreover, the treatment of periodontitis impacts metabolic control and reduction of systemic inflammation in patients with type 2 DM. 26,27…”

Section: Resultsmentioning

confidence: 99%

The Severity of Periodontitis in Elderly Patients with Type 2 Diabetes Mellitus: A Community-Based Study

Utami,

Kusnanto,

Pramono

et al. 2024

European Journal of General Dentistry

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Objective Indonesia is one of the top five countries with the highest prevalence of diabetes mellitus (DM). There were 18 million DM patients in 2020, and this number has doubled in has doubled in 2022. The main complication of DM in the oral cavity is periodontitis. Periodontitis and DM have a bidirectional relationship. Controlling the severity of both diseases can improve the quality of life of DM patients. The aim of this study is to determine the severity of periodontitis in older people with type 2 DM. Material and Methods This research is observational with a cross-sectional design. The research subjects were 263 patients aged ≥ 60 years, taken using a purposive sampling technique. The diagnosis and severity of periodontitis were based on the European Federation of Periodontology (EFP) and the American Academy of Periodontology (AAP) with the Centers for Disease Control and Prevention (CDC), using the clinical attachment loss (CAL) and probing depth (PD) clinical parameters. The diagnosis of DM was established by measuring HbA1c. Descriptive statistics was used to describe the distribution of severity of periodontitis. Results In total, 42 people (16%) in this study did not experience periodontitis, and 221 people (84%) experienced periodontitis with 4.5% of the study population suffering from mild periodontitis, 21.3% moderate periodontitis, and 74.2% severe periodontitis. The results of this study indicated that severe periodontitis was the most common category in patients with type 2 DM. Severe periodontitis is the most common type of periodontitis at all levels of age, occupation, and education. It was found most commonly among those aged 60 to 65 years, housewives, and those with elementary education level with moderate or poor oral hygiene. Conclusion Almost all respondents who suffered from type 2 DM experienced periodontitis, severe periodontitis being most common category at all age levels, occupations, education, and oral hygiene status. The severity of periodontitis in this study tended to be due to high HbA1c levels.

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“…Conversely, periodontitis is now known as a risk factor for worsening glycemic control and may increase the risk for diabetic complications (Nguyen et al, 2020;Santonocito et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Comparing the activity level of salivary matrix metalloproteinase‐8 in patients with diabetes and moderate to severe chronic generalized periodontitis

Tavakoli,

Faramarzi,

Salimnezhad

et al. 2024

Clinical & Exp Dental Res

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ObjectivesThe response of the host to plaque can be affected by systemic diseases like diabetes, hormonal changes, or immunological deficits, which can hasten the progression and severity of periodontitis. This study aimed to compare the activity of salivary matrix metalloproteinase‐8 (MMP‐8) in patients with moderate to severe generalized chronic generalized periodontitis between healthy individuals and those with type 2 diabetes who were referred to the Tabriz School of Dentistry.Materials and MethodsFor this cross‐sectional study, 90 patients were randomly divided into three groups based on inclusion and exclusion criteria: patients with chronic generalized periodontitis with diabetes, patients with generalized chronic periodontal disease with normal blood glucose, and a control group of 30 healthy individuals. Participants were instructed not to brush their teeth for 12 h and not to eat or drink for 90 min before saliva sampling. Saliva samples were immediately stored at −80°C and analyzed using an ELISA test.ResultsThe results showed that there was a significant difference in salivary MMP‐8 levels among the three groups. Patients with periodontitis and diabetes had the highest levels of salivary MMP‐8, while the control group had the lowest levels. This indicates that chronic generalized periodontitis is strongly associated with the activity level of salivary MMP‐8, and elevated levels of MMP‐8 in diabetic patients demonstrate the impact of diabetes on periodontal disease.ConclusionThis study highlights the importance of monitoring salivary MMP‐8 levels in patients with periodontitis, especially those with diabetes. It also emphasizes the need for proper management of systemic diseases to prevent or slow down the progression of periodontal disease.

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Impact of Periodontitis on Glycemic Control and Metabolic Status in Diabetes Patients: Current Knowledge on Early Disease Markers and Therapeutic Perspectives

Cited by 13 publications

References 50 publications

Comparative Analysis of Edentulism in a Sample of Mexican Adults with and without Type 2 Diabetes

Comparative Analysis of Edentulism in a Sample of Mexican Adults with and without Type 2 Diabetes

The Severity of Periodontitis in Elderly Patients with Type 2 Diabetes Mellitus: A Community-Based Study

Comparing the activity level of salivary matrix metalloproteinase‐8 in patients with diabetes and moderate to severe chronic generalized periodontitis

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