Impact of perioperative administration of synbiotics in patients with esophageal cancer undergoing esophagectomy: A prospective randomized controlled trial

Tanaka, Koji; Yano, Masahiko; Motoori, Masaaki; Kutsukake, Kentaro; Miyashiro, Isao; Ohue, Masayuki; Ohigashi, Hajime; Asahara, Takashi; Nomoto, Koji; Ishikawa, Osamu

doi:10.1016/j.surg.2012.02.021

Cited by 72 publications

(77 citation statements)

References 47 publications

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“…The beneficial effects of perioperative synbiotic treatment have also been shown in liver resection for biliary cancer [5,6] . Moreover, the perioperative administration of synbiotics in patients with esophagectomy has been shown to suppress an excessive inflammatory response through the adjustment of the intestinal microfloral environment [19] . A similar study performed at our institution demonstrated that bacterial translocation to the MLNs was suppressed by the perioperative use of synbiotics, and this beneficial effect may contribute to a reduction in the inflammatory response after esophagectomy [8] .…”

Section: Discussionmentioning

confidence: 99%

Effect of Perioperative Synbiotic Treatment on Bacterial Translocation and Postoperative Infectious Complications after Pancreatoduodenectomy

Yokoyama

Miyake²,

Kokuryo³

et al. 2016

Dig Surg

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Background/Aims: This study investigated the effect of perioperative synbiotics on bacterial translocation to mesenteric lymph nodes (MLNs) and occurrence of infectious complications following pancreatoduodenectomy (PD; University Hospital Medical Information Network ID 000003705). Methods: Patients who were scheduled to undergo PD were randomized to receive preoperative synbiotics or no synbiotics (control group). MLNs were harvested at laparotomy (MLN-1) and after the resection (MLN-2). Blood samples were collected before laparotomy (Blood-1) and on postoperative day 1 (Blood-2). Microorganisms in each sample were detected using a bacterium-specific ribosomal RNA-targeted reverse transcriptase-quantitative polymerase chain reaction. Results: Forty-four patients were included. In all samples, the bacterial detection rate in the MLN-1, MLN-2, Blood-1, and Blood-2 was lower in the synbiotics group than in the control group, although it did not reach a statistically significant difference. There was a significant correlation between the positivity of bacteria in the MLN-2 and Blood-2 samples (p = 0.009). The incidence rate of overall infectious complications was not significantly different between the 2 groups. Among various perioperative factors, the incidence of pancreatic fistula was the only factor that had a significant association with the incidence of infectious complications. Conclusion: The preoperative use of synbiotics did not affect the incidence of infectious complications following PD.

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Section: Discussionmentioning

confidence: 99%

Effect of Perioperative Synbiotic Treatment on Bacterial Translocation and Postoperative Infectious Complications after Pancreatoduodenectomy

Yokoyama

Miyake²,

Kokuryo³

et al. 2016

Dig Surg

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“…Administration of synbiotics prevented postoperative deterioration of the intestinal microfloral environment and suppressed excessive inflammatory response, possibly by exerting immunomodulatory effects and by inhibiting bacterial translocation [88,89]. Additionally, synbiotics led to decreased incidence of severe diarrhea and lower interruption or reduction of enteral nutrition.…”

Section: Esophageal Abnormalitiesmentioning

confidence: 99%

“…Additionally, synbiotics led to decreased incidence of severe diarrhea and lower interruption or reduction of enteral nutrition. Passage of flatus postoperatively occurred significantly earlier in patients who received synbiotics than in the control group, suggesting that synbiotics maintain intestinal motility [88]. Taking all the aforementioned things into consideration, larger scale studies are needed in order to define whether or not immunonutrition has beneficial effects on the postoperative outcome of esophageal cancer patients.…”

Section: Esophageal Abnormalitiesmentioning

confidence: 99%

Nutritional Management of Esophageal Cancer Patients

Schizas¹,

Lidoriki²,

Moris³

et al. 2017

Esophageal Abnormalities

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Esophageal cancer is associated with malnutrition in the vast majority of patients. This phenomenon is partly attributed to the disease process itself, the location of the tumor and other factors, such as dysphagia which is often accentuated due to chemotherapy/ radiotherapy treatment or surgical intervention. The poor nutritional status of these patients is often related to the presence of cancer cachexia, altered metabolism, and tissue wasting. Malnutrition in this patient population affects quality of life, worsens patient's tolerance to chemotherapy and accounts for lower survival. Nutritional management of these patients includes both proper nutritional assessment and support and might prevent, to a certain extent, the manifestation of malnutrition-related consequences. The purpose of this article is to review the current literature in order to focus on the etiology and diagnosis of malnutrition in esophageal cancer patients, emphasizing also on the optimal nutritional support during multimodality treatment.

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“…This takes the form of defense against bacterial translocation and infectious complications in seriously ill patients, including perioperative patients with bile duct cancer (21,39), esophageal cancer (51,52), hepatic cirrhosis (53), and colorectal cancer (54), patients undergoing cancer chemotherapy (55), systemic inflammatory response syndrome (SIRS) patients (40), and patients on long-term mechanical ventilation (56). Moreover, research has suggested that improvement of dysbiosis and activity to improve the intestinal environment (pH and organic acid [acetic acid] level) are important in the mechanism for this protective effect against infections.…”

Section: Figmentioning

confidence: 99%

Protective Effect of a Synbiotic against Multidrug-Resistant Acinetobacter baumannii in a Murine Infection Model

Asahara

Takahashi

Yuki

et al. 2016

Antimicrob Agents Chemother

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Impact of perioperative administration of synbiotics in patients with esophageal cancer undergoing esophagectomy: A prospective randomized controlled trial

Cited by 72 publications

References 47 publications

Effect of Perioperative Synbiotic Treatment on Bacterial Translocation and Postoperative Infectious Complications after Pancreatoduodenectomy

Effect of Perioperative Synbiotic Treatment on Bacterial Translocation and Postoperative Infectious Complications after Pancreatoduodenectomy

Nutritional Management of Esophageal Cancer Patients

Protective Effect of a Synbiotic against Multidrug-Resistant Acinetobacter baumannii in a Murine Infection Model

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