Impact of Peroxisome Proliferator–activated Receptors γ and δ on Adiposity in Toddlers and Preschoolers in the GENESIS Study

Lagou, Vasiliki; Scott, Robert A.; Μanios, Yannis; Chen, Tun-Li Joshua; Wang, Guan; Grammatikaki, Evangelia; Kortsalioudaki, Christine; Liarigkovinos, Thodoris; Moschonis, George; Roma-Giannikou, Eleftheria; Pitsiladis, Yannis

doi:10.1038/oby.2008.140

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…Our main objective was to analyse the effects of a Mediterranean dietary pattern depending on the Pro12Ala polymorphism of the PPARg gene. We found a minor 12Ala allele frequency of 0•07, lower than values reported in Spanish subjects (0•13) (28) but similar to those obtained in European populations (30) .…”

Section: Discussionsupporting

confidence: 84%

The Mediterranean diet protects against waist circumference enlargement in 12Ala carriers for the PPARγ gene: 2 years' follow-up of 774 subjects at high cardiovascular risk

et al. 2009

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The PPARg gene regulates insulin sensitivity and adipogenesis. The Pro12Ala polymorphism of this gene has been related to fat accumulation. Our aim was to analyse the effects of a 2-year nutritional intervention with Mediterranean-style diets on adiposity in high-cardiovascular risk patients depending on the Pro12Ala polymorphism of the PPARg gene. The population consisted of a substudy (774 high-risk subjects aged 55-80 years) of the Prevención con Dieta Mediterránea (PREDIMED) randomised trial aimed at assessing the effect of the Mediterranean diet for CVD prevention. There were three nutritional intervention groups: two of them of a Mediterranean-style diet and the third was a control group advised to follow a conventional low-fat diet. All the participants were genotyped by PCR-restriction fragment length polymorphism (RFLP). The results showed that carriers of the 12Ala allele allocated to the control group had a statistically significant higher change in waist circumference (adjusted difference coefficient ¼ 2·37 cm; P¼ 0·014) compared with wild-type subjects after 2 years of nutritional intervention. This adverse effect was not observed among 12Ala carriers allocated to both Mediterranean diet groups. In diabetic patients a statistically significant interaction between Mediterranean diet and the 12Ala allele regarding waist circumference change was observed (2 5·85 cm; P¼ 0·003). In conclusion, the Mediterranean diet seems to be able to reduce waist circumference in a high-cardiovascular risk population, reversing the negative effect that the 12Ala allele carriers of the PPARg gene appeared to have. The beneficial effect of this dietary pattern seems to be higher among type 2 diabetic subjects.

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Section: Discussionsupporting

confidence: 84%

The Mediterranean diet protects against waist circumference enlargement in 12Ala carriers for the PPARγ gene: 2 years' follow-up of 774 subjects at high cardiovascular risk

et al. 2009

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“…The activation of PPARD results in the increased expression of genes involved in lipid uptake, fatty acid oxidation and uncoupling proteins, highlighting the PPARD prominent role in mitochondrial activity [ 13 , 14 ]. PPARD gene variants have been associated with obesity [ 15 - 17 ], although some authors have failed to replicate this finding [ 18 - 21 ]. Recent reports have associated PPARD polymorphisms with the effectiveness of cardiovascular fitness, demonstrating the pivotal role of PPARD gene variants in mitochondrial function and, in consequence, in weight control [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Interaction between Calpain-5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity.

Sáez¹,

Grilo

Morón³

et al. 2008

Cardiovasc Diabetol

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ContextObesity is a multifactorial disorder, that is, a disease determined by the combined effect of genes and environment. In this context, polygenic approaches are needed.ObjectiveTo investigate the possibility of the existence of a crosstalk between the CALPAIN 10 homologue CALPAIN 5 and nuclear receptors of the peroxisome proliferator-activated receptors family.DesignCross-sectional, genetic association study and gene-gene interaction analysis.SubjectsThe study sample comprise 1953 individuals, 725 obese (defined as body mass index ≥ 30) and 1228 non obese subjects.ResultsIn the monogenic analysis, only the peroxisome proliferator-activated receptor delta (PPARD) gene was associated with obesity (OR = 1.43 [1.04–1.97], p = 0.027). In addition, we have found a significant interaction between CAPN5 and PPARD genes (p = 0.038) that reduces the risk for obesity in a 55%.ConclusionOur results suggest that CAPN5 and PPARD gene products may also interact in vivo.

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Impact of Peroxisome Proliferator–activated Receptors γ and δ on Adiposity in Toddlers and Preschoolers in the GENESIS Study

Cited by 2 publications

References 27 publications

The Mediterranean diet protects against waist circumference enlargement in 12Ala carriers for the PPARγ gene: 2 years' follow-up of 774 subjects at high cardiovascular risk

The Mediterranean diet protects against waist circumference enlargement in 12Ala carriers for the PPARγ gene: 2 years' follow-up of 774 subjects at high cardiovascular risk

Interaction between Calpain-5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity.

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