Impact of physical activity on functioning of patients with first-episode psychosis — A 6months prospective longitudinal study

H, Lee; Hui, Christy Lai Ming; Chang, Wing Chung; Li, Yuet-Keung; Lee, Jenny T M; Lin, J.; Chen, Eric

doi:10.1016/j.schres.2013.08.034

Cited by 28 publications

(19 citation statements)

References 16 publications

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“…week AE intervention, while some RCTs using low-intensity AE compared to a yoga intervention reported increases in social functioning [70,71]. In another study, Lee et al [72] discovered that physical activity among firstepisode SZ patients predicted better functioning 6 months later, while one meta-analysis found a moderate influence of physical activity on quality of life [73]. Finally, in results from our recent pilot RCT [74], patients with SZ who completed the AE intervention improved their daily functioning, as indexed using the informant-based Specific Level of Functioning Scale (SLOF), compared to participants in the TAU control group.…”

Section: Of 33mentioning

confidence: 99%

Improving Cognition via Exercise (ICE): Study Protocol for a Multi-Site, Parallel-Group, Single-Blind, Randomized Clinical Trial Examining the Efficacy of Aerobic Exercise to Improve Neurocognition, Daily Functioning, and Biomarkers of Cognitive Change in Individuals with Schizophrenia

Ospina

Wall

Jarskog

et al. 2019

J Psychiatry Brain Sci

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Individuals with schizophrenia (SZ) display cognitive deficits that have been identified as major determinants of poor functioning and disability, representing a serious public health concern and an important target for interventions. At present, available treatments offer only minimal to moderate benefits to ameliorate cognitive deficits. Thus, there remains an urgent need to identify novel interventions to improve cognition in people with SZ. Emerging evidence from animal and basic human research suggests aerobic exercise training (AE) has beneficial effects on cognition. Preliminary findings suggest that AE is efficacious in improving cognitive functioning in SZ, however the extant studies have been limited by small samples, a dearth of information on biologically-relevant covariates, and limited information on impact on daily functioning. Additionally, while AE-related cognitive benefits have been linked to Brain-Derived Neurotrophic Factor (BDNF) upregulation, this putative mechanism needs

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Section: Of 33mentioning

confidence: 99%

Improving Cognition via Exercise (ICE): Study Protocol for a Multi-Site, Parallel-Group, Single-Blind, Randomized Clinical Trial Examining the Efficacy of Aerobic Exercise to Improve Neurocognition, Daily Functioning, and Biomarkers of Cognitive Change in Individuals with Schizophrenia

Ospina

Wall

Jarskog

et al. 2019

J Psychiatry Brain Sci

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“…Recent observational studies have similarly reported a positive association between exercise and better functional outcomes in FEP. [4][5][6] Previous research in long-term schizophrenia has shown that improving physical fitness may also reduce cognitive deficits, possibly through increasing brain-derived neurotrophic factor. [38][39][40] Deficits in verbal STM and processing speed are common in FEP and predictive of overall functioning.…”

Section: Exercise and Mental Healthmentioning

confidence: 99%

“…4 Cross-sectional studies have also indicated that physical activity and fitness are associated with improved functional outcomes. 5,6 Additionally, FEP is a critical period for attenuating weight gain and metabolic dysfunction, which begins within weeks of starting antipsychotic medication. 7,8 There is a fivefold increase in metabolic syndrome within the first few years of treatment, 9 which heightens the risk of cardiovascular diseases and contributes towards the premature mortality of 15-20 years for people with schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Exercise as an intervention for first‐episode psychosis: a feasibility study

Firth

Carney

Elliott

et al. 2016

Early Intervention Psych

107

124

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AimExercise can improve psychiatric symptoms, neurocognitive functioning and physical health in schizophrenia. However, the effects in early psychosis have not been explored. This study aimed to assess the feasibility of an exercise intervention for early psychosis and to determine if it was associated with changes in physical and mental health.MethodsThirty‐one patients with first‐episode psychosis (FEP) were recruited from early intervention services to a 10‐week exercise intervention. The intervention group received individualized training programmes, aiming to achieve ≥90 min of moderate‐to‐vigorous activity each week, using exercise programmes tailored to individual preferences and needs. A comparison FEP sample from the same services (n = 7) received treatment as usual.ResultsRates of consent and retention in the exercise group were 94% and 81%, respectively. Participants achieved an average of 107 min of moderate‐to‐vigorous exercise per week. Positive and Negative Syndrome Scale total scores reduced by 13.3 points after 10 weeks of exercise, which was significantly greater than the treatment as usual comparison group (P = 0.010). The greatest differences were observed in negative symptoms, which reduced by 33% in the intervention group (P = 0.013). Significant improvements were also observed in psychosocial functioning and verbal short‐term memory. Increases in cardiovascular fitness and processing speed were positively associated with the amounts of exercise achieved by participants.ConclusionIndividualized exercise training could provide a feasible treatment option for improving symptomatic, neurocognitive and metabolic outcomes in FEP.

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“…Low physical activity is associated with more frequent occurrence of T2D (10), more metabolic disturbances, reduced global functioning, and lower quality-of-life (9,(11)(12)(13). A systematic search for all studies evaluating physical activity in patients with first-episode schizophrenia (FES) revealed only four studies (13)(14)(15)(16). Findings from these few studies suggest that physical activity is lower in patients with FES than in healthy controls, but higher than in patients with multi-episode schizophrenia, indicating that physical activity declines over the course of schizophrenia (16).…”

Section: Introductionmentioning

confidence: 99%

Physical activity and anomalous bodily experiences in patients with first-episode schizophrenia

Nyboe

Moeller

Vestergaard

et al. 2016

Nordic Journal of Psychiatry

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Impact of physical activity on functioning of patients with first-episode psychosis — A 6months prospective longitudinal study

Cited by 28 publications

References 16 publications

Improving Cognition via Exercise (ICE): Study Protocol for a Multi-Site, Parallel-Group, Single-Blind, Randomized Clinical Trial Examining the Efficacy of Aerobic Exercise to Improve Neurocognition, Daily Functioning, and Biomarkers of Cognitive Change in Individuals with Schizophrenia

Improving Cognition via Exercise (ICE): Study Protocol for a Multi-Site, Parallel-Group, Single-Blind, Randomized Clinical Trial Examining the Efficacy of Aerobic Exercise to Improve Neurocognition, Daily Functioning, and Biomarkers of Cognitive Change in Individuals with Schizophrenia

Exercise as an intervention for first‐episode psychosis: a feasibility study

Physical activity and anomalous bodily experiences in patients with first-episode schizophrenia

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