Impact of physical exercise intervention and PPARγ genetic polymorphisms on cardio-metabolic parameters among a Chinese youth population

Abstract

ObjectivePhysical inactivity inChinese youth students particularly in senior high schools, who participate inthe National Higher Education Entrance Examination (NCEE) is very common. Inorder to explore the beneficial effects from physical exercise and education afterNCEE, we performed a Physicalexercise Intervention Program in the Youth (PiPy) to evaluate the interaction with PPARγ genetic variants on cardiovascular and metabolicparameters.MethodsA total of 772 freshmen (males 610/females162) from high schools to university were recruited into the PiPy cohort, which was designedaccording to the National Student Health Standards in China. Anthropometric data were collected, whilephysical activities and body composition at the baseline of PiPy cohort weremeasured with SECAprotocols. Eighttagged single nucleotide polymorphisms (SNPs) in the PPARγ gene were genotyped with TaqMan allelicdiscrimination.ResultsAfter physical exercise intervention forthree months, in parallel with increased physical activities, BMI and skeletalmuscle content in all subjects was enhanced, while heart rate and bloodpressures were decreased. Furthermore, SNPs in 5’-UTR of the PPARγ gene, including rs2920502,rs9817428 and rs2972164, were found to be associated with the changes of BMI.Body weight in the subjects with BMI <18.5and 18.5-23.9 kg/m2 were increased,while the obese subjects (BMI ≥24.0 kg/m2) decreased.ConclusionThe present study for the first timedemonstrated that the PiPy could improve cardio-metabolic parameters such asheart rate, blood pressures and BMI for Chinese youth students after NCEE, inwhich the genetic interactive effects of PPARγ should be included into obesityintervention.

Highlighting the novel effects of high-intensity interval training on some histopathological and molecular indices in the heart of type 2 diabetic rats

“…Type 2 diabetes (T2DM) is one of the most common metabolic disorders worldwide, which is caused by a combination of two main factors: defective insulin secretion by pancreatic beta cells and the inability of insulin-sensitive tissues to respond appropriately to insulin (1). According to the International Diabetes Federation (IDF), 9.3% (463 million) of adults worldwide had diabetes in 2019, and this figure is expected to increase to 10.2% (578 million) by 2030 to increase to 10.9 percent (700 million) by 2045 (2). The prevalence of T2DM among adults and young people has caused great concern, and people with T2DM in youth often have a more aggressive clinical course than people with T2 diabetes in adulthood (3).…”

Effects of PPARG and PPARGC1A gene polymorphisms on obesity markers

“…They found that young Polish women with CC PPARG rs1801282 genotype had a better response for body fat mass variables compared to G allele carriers after a 12-week training program ( 77 ). However, data on this previously debated matter is scarce in the pediatric population and has been so far limited to adolescents, in whom a physical exercise intervention might imply a better compliance as opposed to younger ages ( 78 ).…”

Highlighting the effects of high-intensity interval training on the changes associated with hypertrophy, apoptosis, and histological proteins of the heart of old rats with type 2 diabetes

“…The prevalence of T2DM is increasing day by day due to the mechanization of living standards, decreased PE, and unhealthy diets. In 2019, 463 million adults worldwide, which accounts for 9.3% of the population, suffered from T2DM, and this number is expected to rise to 578 million (10.2%) by 2030 and 700 million (10.9%) by 2045 4 . Understanding some of the cellular mechanisms underlying this disorder can be helpful in developing appropriate treatment strategies.…”