Impact of PLA/Mg films degradation on surface physical properties and biofilm survival

Fernández-Calderón, María Coronada; Romero-Guzmán, Daniel; Ferrández-Montero, Ana; Pérez-Giraldo, Ciro; González-Carrasco, José Luis; Lieblich, Marcela; Benavente, Rosario; Ferrari, B.; González-Martı́n, M.L.; Gallardo-Moreno, Amparo M.

doi:10.1016/j.colsurfb.2019.110617

Cited by 22 publications

(20 citation statements)

References 46 publications

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“…Indeed, studies on PLA blends with PEO (co)polymers show significant reduction in material’s contact angle [ 32 ]. Figure 3 shows that the PLA has a contact angle of 93° in good agreement with literature data [ 23 ]. The addition of 5, 10 and 15 wt.% of the hydrophilic Mg filler renders the composite surface less hydrophobic with a contact angle of 84, 81 and 79°, respectively, as expected.…”

Section: Resultssupporting

confidence: 88%

“…Moreover, it provides excellent bioresorbability, biodegradability and more similar mechanical properties to those of bones compared to any other metal or polymer [ 22 ]. Mg-based orthopaedic implants have presented attractive abilities of bioactive behaviour, osteoconductivity and osseointegration, and have encouraged bone growth [ 23 ]. Mg inorganic filler was also embedded in a PLA and was found not only to enhance its mechanical performances but also to increase the bioactivity and so the improvement of protein adsorption leading to more cell adhesion and growth [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Interfacial Compatibilization into PLA/Mg Composites for Improved In Vitro Bioactivity and Stem Cell Adhesion

et al. 2021

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The present work highlights the crucial role of the interfacial compatibilization on the design of polylactic acid (PLA)/Magnesium (Mg) composites for bone regeneration applications. In this regard, an amphiphilic poly(ethylene oxide-b-L,L-lactide) diblock copolymer with predefined composition was synthesised and used as a new interface to provide physical interactions between the metallic filler and the biopolymer matrix. This strategy allowed (i) overcoming the PLA/Mg interfacial adhesion weakness and (ii) modulating the composite hydrophilicity, bioactivity and biological behaviour. First, a full study of the influence of the copolymer incorporation on the morphological, wettability, thermal, thermo-mechanical and mechanical properties of PLA/Mg was investigated. Subsequently, the bioactivity was assessed during an in vitro degradation in simulated body fluid (SBF). Finally, biological studies with stem cells were carried out. The results showed an increase of the interfacial adhesion by the formation of a new interphase between the hydrophobic PLA matrix and the hydrophilic Mg filler. This interface stabilization was confirmed by a decrease in the damping factor (tanδ) following the copolymer addition. The latter also proves the beneficial effect of the composite hydrophilicity by selective surface localization of the hydrophilic PEO leading to a significant increase in the protein adsorption. Furthermore, hydroxyapatite was formed in bulk after 8 weeks of immersion in the SBF, suggesting that the bioactivity will be noticeably improved by the addition of the diblock copolymer. This ceramic could react as a natural bonding junction between the designed implant and the fractured bone during osteoregeneration. On the other hand, a slight decrease of the composite mechanical performances was noted.

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Section: Resultssupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Interfacial Compatibilization into PLA/Mg Composites for Improved In Vitro Bioactivity and Stem Cell Adhesion

et al. 2021

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“…Beberapa penelitian telah dilakukan mengenai penggunaan material yang melepaskan ion bioaktif seperti Zn 2 + , Si 4 + dan Mg 2 + untuk regenerasi jaringan pada area yang mengalami kerusakan dalam tubuh manusia [13]- [15]. Ion Mg 2+ memiliki kelebihan tersendiri karena sangat penting dalam metabolisme pada tubuh manusia, seperti sintesis protein, fungsi otot, sistem saraf dan kekebalan [10]- [11].…”

Section: Pendahuluanunclassified

“…Penambahan logam Mg pada polimer selain karena manfaat ion yang dihasilkan juga memiliki sifat-sifat yang dapat terurai secara alami di dalam tubuh. Kehadiran Mg pada komposit juga dapat meningkatkan sifat mekanik polimer dan dengan adanya polimer dapat mengendalikan laju degradasi Mg. Selain untuk meningkatkan sifat mekanik Mg, polimer juga dapat meningkatkan sifat kekuatan mulur (creep) dan biokompatibilitas dari Mg [15].…”

Section: Pendahuluanunclassified

Pengaruh Penambahan Magnesium Terhadap Sifat Mekanik, Mikrostruktur Dan Electrochemical Impedance Spectroscopy Polimer Pla/Abs Untuk Material Implan Bioabsorbabel

Erryani¹

2020

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Pada penelitian ini telah dilakukan pembuatan implan bioabsorbable dengan bahan polimer logam komposit (PLA/ABS/Mg) dengan menggunakan metode solvent casting dengan tiga komposisi yakni PLA:ABS 70:30, 60:40, 80:20 dengan komposisi Mg masing-masing 5%, 10% dan 15% kemudian dilarutkan dengan clorofoam sebanyak 17 mL sehingga mendapatkan sampel berbentuk film. Penelitian ini bertujuan untuk mengetahui variasi optimal PLA/ABS terhadapat karakterisitik sifat mekanik, morfologi, impedansi dengan adanya penambahan Mg. Hasil karakterisasi sifat mekanik menggunakan uji tarik dengan komposisi PLA:ABS 80:20 pada variasi Mg 10% dan 15% menunjukkan hasil yang optimal, sehingga Mg terbukti meningkatkan sifat mekanik dari PLA. Semakin banyak penambahan variasi Mg menunjukkan peningkatan nilai kekerasan vikers dan impedansi pada polimer logam komposit. Hasil pengamatan dengan menggunakan SEM pada kompoisi PLA:ABS 70:30 menunjukan bahwa homogenitas Mg didalam polimer telah tercapai dengan baik.

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“…According to this, recently it has been demonstrated the feasibility of including Mg particles within a polymer matrix such as polylactic acid (PLA) [13][14][15]. It has been proved that Mg promotes in vitro cell proliferation and the initial induction of osteogenesis [16][17][18][19][20] and reduces biofilm formation [19]. In addition, Mg improves composite mechanical properties [18,21], accelerates the degradation rate [22,23], and prevents the acidification of the medium resulting from the degradation of the polymer [24].…”

Section: Introductionmentioning

confidence: 99%

Controlled SrR Delivery by the Incorporation of Mg Particles on Biodegradable PLA-Based Composites

et al. 2021

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Among several ions playing a vital role in the body, Sr2+ and Mg2+ are involved in the mechanism of bone formation, making them especially useful for bone tissue engineering applications. Recently, polylactic acid (PLA)/Mg composites have emerged as a promising family of biomaterials due to their inherent biocompatibility and biodegradability properties. In these composites, polymer and bio-metal have a synergetic effect—while the PLA inhibits the Mg fast reactivity, Mg provides bioactivity to the inert polymer buffering the medium pH during degradation. Meanwhile, the typical form of administrating Sr2+ to patients is through the medication strontium ranelate (SrR), which increases the bone mineral density. Following this interesting research line, a new group of composites, which integrates Mg particles and SrR charged onto halloysite nanotubes (HNT) in a polymeric matrix, was proposed. PLA/Mg/SrR–HNT composites have been processed following a colloidal route, obtaining homogenous composites granulated and film-shaped. The drug delivery profile was evaluated in terms of in vitro lixiviation/dissolution paying special attention to the synergism of both ions release. The combination of two of the most reported ions involved in bone regeneration in the composite biomaterial may generate extra interest in bone healing applications.

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Impact of PLA/Mg films degradation on surface physical properties and biofilm survival

Cited by 22 publications

References 46 publications

Interfacial Compatibilization into PLA/Mg Composites for Improved In Vitro Bioactivity and Stem Cell Adhesion

Interfacial Compatibilization into PLA/Mg Composites for Improved In Vitro Bioactivity and Stem Cell Adhesion

Pengaruh Penambahan Magnesium Terhadap Sifat Mekanik, Mikrostruktur Dan Electrochemical Impedance Spectroscopy Polimer Pla/Abs Untuk Material Implan Bioabsorbabel

Controlled SrR Delivery by the Incorporation of Mg Particles on Biodegradable PLA-Based Composites

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