Impact of Placental Plasmodium falciparum Malaria on the Profile of Some Oxidative Stress Biomarkers in Women Living in Yaoundé, Cameroon

Megnekou, Rosette; Djontu, Jean Claude; Bigoga, Jude D.; Medou, Fabrice Mbah; Tenou, Sandrine; Lissom, Abel

doi:10.1371/journal.pone.0134633

Cited by 35 publications

(53 citation statements)

References 25 publications

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“…In that work, the level of cell membrane lipid peroxidation, detected as malondialdehyde, was significantly increased in the placentas of malaria-infected and anemic women compared with noninfected and nonanemic counterparts (8). Moreover, oxidative stress was observed in a murine model of PM caused by P. berghei ANKA (9–11), which yields many features of human PM but is limited by parasite virulence and maternal mortality, restricting studies to late pregnancy.…”

Section: Introductionmentioning

confidence: 85%

“…In addition to these pathogenic findings in PM, a recent study showed that poor pregnancy outcomes may also be attributed to malaria-induced oxidative stress in the placenta (8). In that work, the level of cell membrane lipid peroxidation, detected as malondialdehyde, was significantly increased in the placentas of malaria-infected and anemic women compared with noninfected and nonanemic counterparts (8).…”

Section: Introductionmentioning

confidence: 99%

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Oxidative Stress: A Potential Therapeutic Target in Placental Malaria

et al. 2017

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Placental malaria, characterized by sequestration of Plasmodium falciparum in the maternal placental blood space and associated inflammatory damage, contributes to poor birth outcomes and ~200,000 infant deaths annually. Specific mechanisms that contribute to placental damage and dysfunction during malaria are not completely understood. To investigate a potential role for oxidative stress, antioxidant genes and markers for oxidative damage were assessed by quantitative PCR and immunohistochemistry in Plasmodium chabaudi AS-infected pregnant mice. Widespread evidence of lipid peroxidation was observed and was associated with higher antioxidant gene expression in conceptuses of infected mice. To assess the extent to which this oxidative damage might contribute to poor birth outcomes and be amenable to therapeutic intervention, infected pregnant mice were treated with N-acetylcysteine, a free radical scavenger, or tempol, an intracellular superoxide dismutase mimetic. The results show that mice treated with N-acetylcysteine experienced malaria induced–pregnancy loss at the same rate as control animals and failed to mitigate placental oxidative damage. In contrast, tempol-treated mice exhibited subtle improvement in embryo survival at gestation day 12. Although lipid peroxidation was not consistently reduced in the placentas of these mice, it was inversely related to embryo viability. Moreover, reduced IFN-γ and CCL2 plasma levels in treated mice were associated with midgestational embryo viability. Thus, although oxidative stress is remarkable in placental malaria and its mitigation by antioxidant therapy may improve pregnancy outcomes, the underlying mechanistic basis and potential therapeutic strategies require additional investigation.

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Section: Introductionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Oxidative Stress: A Potential Therapeutic Target in Placental Malaria

et al. 2017

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“…This oxidative stress has been reported in several placental disorders, pregnancy pathologies, and also in PAM [54, 55]. Malondialdehyde (MDA) is correlated positively with parasitaemia and NO is correlated negatively with birth weight [55]. sFlt-1 is also increased during PAM and associated with fetal loss, intra-uterine growth restriction, and placental inflammation.…”

Section: Introductionmentioning

confidence: 92%

“…Other factors, such as nitric oxide synthase, s-endoglin, or TGF-ß soluble receptor are associated to preeclampsia, but also to severe malaria in children and in infected primigravidae [44]. This oxidative stress has been reported in several placental disorders, pregnancy pathologies, and also in PAM [54, 55]. Malondialdehyde (MDA) is correlated positively with parasitaemia and NO is correlated negatively with birth weight [55].…”

Section: Introductionmentioning

confidence: 99%

Usefulness of a biomarker to identify placental dysfunction in the context of malaria

Gueneuc

Deloron

Bertin

2017

Malar J

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In most tropical areas, pregnant women are at increased risk of malaria, as a consequence of the massive sequestration of parasitized red blood cells in the placenta. The placenta plays a key role in embryonic and fetal development as well as in maternal-fetal exchanges, and pregnancy-associated malaria may alter selected placenta functions that lead to stillbirth and low birth weight. Although there are several tools (blood smear examination, RDT, PCR) to diagnose malaria infection during pregnancy, there is currently no test to assess placenta dysfunction in the framework of pregnancy-associated malaria. Pregnancy-associated malaria shares many features with preeclampsia, an extensively studied disease. Various biomarkers associated with placental dysfunction have been identified as associated with preeclampsia. Several of these are inflammatory markers that lack of specificity. A few seem more specific of placenta dysfunction, including s-endoglin and sFlt1, increased in the peripheral blood during preeclampsia. The predictive value of these biomarkers should be studied in the context of pregnancy-associated malaria to evaluate their usefulness in identifying placental dysfunction during malaria. These biomarkers should be considered to improve the diagnosis of placental dysfunction during malaria and pregnant women monitoring.

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“…Indeed, a successful pregnancy is characterized by the predominance of anti-inflammatory cytokines at the feto-maternal interface that downregulates inflammatory response, which could be detrimental to the fetus [9]. Also, the accumulation of Plasmodium falciparum -infected erythrocytes and leucocytes in the placenta is associated with alteration in cytokine expression and some oxidative stress biomarkers profiles [10, 11]. The infiltrated leukocytes are the principal sources of inflammatory cytokines production [8, 12].…”

Section: Introductionmentioning

confidence: 99%