Impact of platelet endothelial aggregation receptor 1 genotypes and DNA methylation on platelet reactivity in patients with recurrent ischemic stroke treated with clopidogrel

Yang, Jiahui; Bao, Zhengjun; Hu, Guoyu; Luo, Xiaofan; Zhao, Zhen

doi:10.5114/aoms/159180

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…[ 21 – 23 ] Although genetic variant PEAR1 rs12041331 was not associated with cardiovascular events in response to low-dose aspirin in a healthy elderly population, genotypes of PEAR1 had impact on platelet reactivity in patients with recurrent IS treated with clopidogrel. [ 24 , 25 ] In addition, PTGS1 gene variations associated with bleeding and platelet dysfunction and PTGS1 gene-smoking interaction might in part reflect the heterogeneity in the prognosis of stroke patients treated with aspirin. [ 26 ] Nevertheless, the association between genetic variations in PEAR1 and PTGS1 and the recurrence of IS treated with aspirin has not been adequately evaluated.…”

Section: Introductionmentioning

confidence: 99%

Effect of PEAR1, PTGS1 gene polymorphisms on the recurrence of aspirin-treated patients with ischemic stroke in the Han population of China: A 4-year follow-up study

Zhang,

Meng,

Wang

et al. 2024

Medicine

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Platelet endothelial aggregation receptor 1 (PEAR1) and prostaglandin endoperoxide synthase 1 (PTGS1) polymorphisms can affect laboratory aspirin resistance. However, the impact of genetic polymorphisms on the recurrence of ischemic stroke (IS) patients treated with aspirin is not fully understood. This study aimed to examine the relationship between gene polymorphisms of PEAR1 and PTGS1 and IS recurrence in patients treated with aspirin. Peripheral blood samples were collected from 174 patients with nonrecurrent IS and 34 with recurrent IS after aspirin treatment. Follow-up was performed on all patients. PEAR1 rs12041331 and PTGS1 rs10306114 polymorphisms were determined using the PCR fluorescence probe method. And the correlations of them with the clinical characteristics were examined by multivariable logistic regression analysis. The distribution frequencies of PEAR1 rs12041331 and PTGS1 rs10306114 genotypes were in Hardy-Weinberg equilibrium, and there was no significant difference in the distribution of PEAR1 rs12041331 polymorphism. Compared to the nonrecurrent group, the AA genotype of the PTGS1 polymorphism was more frequent in the recurrent group (59.77% vs 35.29%, P = .003), and the A allele also showed a higher frequency than the G allele in the recurrent group (P = .001). Multivariable logistic regression analysis showed that smoking (OR = 5.228, 95% CI: 1.938–14.102, P = .001), coronary heart disease (OR = 4.754, 95% CI: 1.498–15.089, P = .008), and the polymorphism at PTGS1(A>G) AA/AG + GG (OR = 2.955, 95% CI: 1.320–6.616, P = .008) were independently associated with IS recurrence in Chinese patients. Our findings suggested that PTGS rs10306114 polymorphisms should receive more attention in the use of aspirin in patients with IS.

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Section: Introductionmentioning

confidence: 99%

Effect of PEAR1, PTGS1 gene polymorphisms on the recurrence of aspirin-treated patients with ischemic stroke in the Han population of China: A 4-year follow-up study

Zhang,

Meng,

Wang

et al. 2024

Medicine

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“…Therefore, it is important to seek effective ways to improve the balance function of patients. Pharmacological treatment is usually used to improve the patient’s overall function, with little mention of single symptom improvement [ 8 ], while surgical treatment requires strict surgical indications [ 9 ] and is not the preferred option in the non-acute phase.…”

Section: Introductionmentioning

confidence: 99%

Effects of different rehabilitation training on balance function in stroke patients: a systematic review and network meta-analysis

Lü

Yin

et al. 2023

Arch Med Sci

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Approximately 83% of people who have had a stroke have some degree of balance dysfunction. Rehabilitation training is an effective means to improve the balance function of stroke patients.The aim of this meta-analysis was to assess which of the eight rehabilitation training was more effective in promoting balance recovery.Relevant studies were searched in eight database species. Data extraction was carried out by two independent researchers.The improvement in balance function included in the study was measured using the Berg Balance Scale (BBS). Meta-analysis results showed that the clinical effectiveness in promoting balance recovery in stroke patients were ranked as follows: core stability training（odds ratio(OR) = 14.98 , 95% confidence interval (CI): 8.18–27.44) > whole-body vibration training（OR= 10.27 , 95%CI: 4.36–24.18).This results suggested that core stability was more beneficial for improving balance function in stroke patients.

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Impact of platelet endothelial aggregation receptor 1 genotypes and DNA methylation on platelet reactivity in patients with recurrent ischemic stroke treated with clopidogrel

Cited by 2 publications

References 14 publications

Effect of PEAR1, PTGS1 gene polymorphisms on the recurrence of aspirin-treated patients with ischemic stroke in the Han population of China: A 4-year follow-up study

Effect of PEAR1, PTGS1 gene polymorphisms on the recurrence of aspirin-treated patients with ischemic stroke in the Han population of China: A 4-year follow-up study

Effects of different rehabilitation training on balance function in stroke patients: a systematic review and network meta-analysis

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