Impact of platelet-rich fibrin therapy in tympanoplasty type 1 surgery on graft survival and frequency-specific hearing outcomes: a retrospective analysis in patients with tympanic membrane perforation due to chronic otitis media

Kütük, Sinem Gökçe; Özdaş, Talih

doi:10.1017/s0022215119002391

Cited by 14 publications

(8 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They concluded that PRF provides more rapid recovery, and better audiological improvement for acute traumatic perforation, compared to the paper patch method. Kütük compared the use of PRF plus temporalis fascia graft with temporalis fascia graft alone, and reported better graft survival rate in temporalis fascia graft plus PRF, similar hearing gain between groups 26 . In this study, the graft success rate in cartilage island graft with an extra perichondrium was 95.5%, while the graft success rate was 100% in the study group.…”

Section: Discussionmentioning

confidence: 60%

The new “cubism” graft technique in tympanoplasty: A randomized controlled trial

Kaya

Şahin

et al. 2021

Laryngoscope Investig Oto

View full text Add to dashboard Cite

Objectives The aim of this prospective, randomized‐controlled study is to analyze the outcomes of a new graft technique in tympanoplasty and compare its outcomes with cartilage island graft plus extra perichondrium. Methods A total of 44 patients with noncomplicated chronic otitis media were included in this prospective randomized‐controlled clinical trial. Patients were randomly divided into 2 double‐layer graft groups: The cartilage island graft + cubism graft (study group) and the cartilage island graft + extra perichondrium (control group). The main outcome measures of the study were the air‐bone gap (ABG), ABG gain, and graft status. Results Graft success rate was 100% and 95.5% in the study group and the control group, respectively. There were statistically significant differences in the postoperative first month ABG and ABG gain between study and control groups (P < .05). ABG and ABG gain showed no significant differences in the postoperative sixth month between groups (P > .05). Conclusion This study revealed that both graft techniques have satisfactory functional and morphological results compared to preoperative findings. The use of cubism graft with cartilage island graft has significantly better auditory outcomes in short‐term and similar results in long‐term compared to double‐layered cartilage island graft with extra perichondrium. Cubism graft is a highly promising graft technique with its many advantages. Level of Evidence 1b.

show abstract

Section: Discussionmentioning

confidence: 60%

The new “cubism” graft technique in tympanoplasty: A randomized controlled trial

Kaya

Şahin

et al. 2021

Laryngoscope Investig Oto

View full text Add to dashboard Cite

show abstract

“…They used PRF as a plug over perforation sealed with temporalis muscle fascia and reported the superiority of PRF plugs in TM healing. Also, Kütük et al 6 reported the superiority of the PRF with temporal fascia graft compared to temporal fascia alone with better functional outcomes in their retrospective controlled study.…”

Section: Discussionmentioning

confidence: 99%

“…Many recent studies reported better functional and surgical results in tympanoplasty with the use of PRP and PRF. 6 - 8 Plasma-derived platelet-rich biomaterials have encouraging results in tympanoplasty, and we believe that they can be an alternative to non-autologous materials. So, controlled clinical studies are mandatory to conclude their potential roles in otology.…”

Section: Introductionmentioning

confidence: 91%

A Comparative Study: Platelet-Rich Fibrin Packing as an Alternative to the Absorbable Gelatine in Tympanoplasty

Turhal¹,

Öztürk²,

Kirazlı³

et al. 2022

Int Adv Otol

View full text Add to dashboard Cite

Background: We aimed to investigate platelet-rich fibrin’s potential role as packing material in both the middle ear and external auditory canal. Methods: Twenty-nine patients undergoing transcanal endoscopic type 1 cartilage tympanoplasty were included in this controlled prospective clinical study. Patients were randomly assigned to platelet-rich fibrin (n = 14) or absorbable gelatine (n = 15) groups. Preoperative and postoperative pure-tone audiometry results, graft healing rates, tympanometry values, and Glasgow Benefit Inventory scores were compared. Results: No significant postoperative complications were observed and the graft intake rate was 100% in both groups. Mean air-bone gap gain was 9.82 ± 4 dB HL in the postoperative first month and 10.08 ± 4.91 dB HL in the sixth postoperative month in the platelet-rich fibrin group. There was no statistically significant difference between the postoperative air-bone gap gains of the groups in the first ( P = .537) and sixth month ( P = .723) controls. There was no statistically significant difference in compliance ( P = .453) between groups. The physical benefit scores of the Glasgow Benefit Inventory were significantly higher in the platelet-rich fibrin group ( P = .01). There was no difference in general and social benefit scores ( P > .05). Conclusion: As a middle and external auditory canal packing agent, platelet-rich fibrin was as successful as absorbable gelatine in transcanal endoscopic cartilage tympanoplasty with similar functional results and graft healing rate.

show abstract

“…Since the PRF is autologous, the chances of immunogenic reaction and graft failure are minimal. The process of preparing PRF is simple, quick, and cheap, does not increase the time of surgery and is also effective in wound healing and reduces the incidence of infections [ 3 , 13 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…Studies in ENT reported the use of PRF, particularly in ear surgery for repairing eardrum perforation [ 7 , 11 ]. PRF serves as a resorbable membrane that provides mechanical and inflammatory protection to the tympanic membrane [ 12 ], thereby improving the post-operative outcomes of ear surgery [ 13 ]. One of the advantages of PRF is its easy accessibility, allowing for unlimited utilization in myringoplasties, unlike the limited availability of cartilage, perichondrium, or temporalis fascia [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Plasma-Rich Fibrin—Regenerative Material in Tympanic Membrane Surgery

et al. 2023

View full text Add to dashboard Cite

Background and Objectives: Platelet-rich fibrin (PRF) membrane plays an important role in cell proliferation and aids in healing. This study aimed to assess the safety and efficacy of the addition of PRF to the graft in tympanoplasty. Materials and Methods: A retrospective study was conducted involving 47 patients with chronic dry eardrum perforation, who were candidates for different types of tympanoplasty (type I-IV). The study took place in the ENT department, County Emergency Clinical Hospital of Cluj-Napoca. In group 1 (27 patients) tympanoplasty was performed with a cartilage graft, while in group 2 (20 patients) a cartilage graft was used with the addition of a PRF membrane. The PRF clot was extracted and transformed into a thin membrane. Postoperative evaluation included otoendoscopy and otomicroscopy at 1, 3, 6, and 12 months after surgery, as well as pure-tone audiometry at 12 months. Results: Postoperative follow-up at 1, 3, 6, and 12 months showed a higher rate of graft survival in the PRF group than in the non-PRF group. At the 12-month mark, a successful outcome was observed in 95.0% of patients in the PRF group, while the success rate in group 1 was 70.4% (p < 0.05). The postoperative hearing threshold value was statistically significantly lower in the group with PRF, compared to the non-PRF group, being 18.4 ± 10.4 dB and 27.6 ± 16.2 dB (p < 0.001), respectively. Although the postoperative air-bone gap value did not differ significantly between groups, there was a greater improvement in the PRF group (p < 0.7). The PRF was well tolerated, and the incisions healed perfectly. Conclusions: The PRF membrane increases the rate of autograft survival and is therefore an effective material for patients with chronic perforations of the tympanic membrane.

show abstract

Impact of platelet-rich fibrin therapy in tympanoplasty type 1 surgery on graft survival and frequency-specific hearing outcomes: a retrospective analysis in patients with tympanic membrane perforation due to chronic otitis media

Cited by 14 publications

References 18 publications

The new “cubism” graft technique in tympanoplasty: A randomized controlled trial

The new “cubism” graft technique in tympanoplasty: A randomized controlled trial

A Comparative Study: Platelet-Rich Fibrin Packing as an Alternative to the Absorbable Gelatine in Tympanoplasty

Plasma-Rich Fibrin—Regenerative Material in Tympanic Membrane Surgery

Contact Info

Product

Resources

About