Impact of Platelet-Rich Plasma on Viability and Proliferation in Wound Healing Processes after External Radiation

Abstract

Platelet-rich plasma is a current subject of studies on chronic wound healing therapy due to possible pro-angiogenic effects. Microvascular compromise represents the major component in radiogenic wound healing complications. The effects of platelet-rich plasma on irradiated cells of the cutaneous wound healing process are poorly understood so far. In this study, the interaction of endothelial cells and adipose-derived stem cells in conjunction with treatment with platelet-rich plasma is investigated in the context of radiation effects. Therefore, the expression of surface-marker CD90 and CD31 was determined. Moreover, cell proliferation and viability after external radiation was analyzed with and without treatment by platelet-rich plasma.

The effect of chrysin–curcumin-loaded nanofibres on the wound-healing process in male rats

“…Different types of immune cells, endothelial cells, keratinocytes and fibroblasts play a pivotal role in wound healing. Moreover, the proliferation, differentiation and cellular migration of the aforementioned cells can play a vital role in the wound healing process [15][16][17].…”

Investigation of platelet‐rich plasma in increasing proliferation and migration of endometrial mesenchymal stem cells and improving pregnancy outcome of patients with thin endometrium

“…Both in vitro and in vivo studies found PRP yields pro‐proliferative and pro‐differentiation properties for various types of stem cells. One study found that cells proliferation and viability after external radiation was enhanced when treated with PRP . Other evidence supported PRP as an important growth factor showed that PRP could efficiently facilitate differentiation and proliferation of stem cells from human exfoliated deciduous teeth (SHEDs), further 2% PRP may be an optimal substitute for 10% fetal bovine serum (FBS) during SHEDs differentiation and expansion in clinical scale manufacturing .…”

Effect of dual‐drug‐releasing micelle–hydrogel composite on wound healing in vivo in full‐thickness excision wound rat model

“…Inflammation also facilitates the removal of bacteria and other infectious pathogens. Proliferation marks the growth of new tissue at the injury site . The beginning of this phase accompanies the start of granulation, with new cells migrating to the site of injury and proliferating.…”

“…Proliferation marks the growth of new tissue at the injury site. 55,56 The beginning of this phase accompanies the start of granulation, with new cells migrating to the site of injury and proliferating. Angiogenesis, connective tissue deposition, re-epithelialization, and wound contraction are the key events of the proliferation phase.…”