Impact of Polycystic Ovary Syndrome on Selected Indicators of <i>In Vitro</i> Fertilization and Intracytoplasmic Sperm Injection Treatment Success

Beydoun, Hind A.; Stadtmauer, Laurel; Zhao, Yueqin; Russell, Helena; Matson, David O.; Oehninger, Sergio

doi:10.1089/jwh.2008.1149

Cited by 8 publications

(18 citation statements)

References 33 publications

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“…Of a total of 4292 studies identified through the search, 77 studies met the inclusion criteria for the systematic review. For the metaanalysis, 14 studies were excluded (Table S4) on the basis of reporting outcomes in multiple number of pregnancies per woman [16][17][18][19][20][21] and overlapping data, [22][23][24][25][26][27][28][29] resulting in 63 included studies ( Figure 1).…”

Section: Search Resultsmentioning

confidence: 99%

“…Outcomes of interest were reported in a total of n = 224 136 pregnant women comprising 39 retrospective 23,31,[33][34][35][36][37][38][39][40][42][43][44][47][48][49]51,53,54,56,57,59,61,62,65,67,69,70,73,74,78,79,81,84,85,87,[89][90][91] (n = 157 899) and 24 prospective 30,32,41,45,46,50,52,55,58,60,63,64,66,…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…Eighteen studies were conducted in Europe, 36,37,42,43,50,51,53,54,57,60,64,75,76,[79][80][81][82]91 16 in Americas, 23,31,32,34,38,39,45,47,49,52,56,58,61,65,72,87 23 in Asia, 30,33,35,44,46,48,55,59,62,66,67,69,70,73,74,77,[83][84]…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…48,54,56,60 Out of all included studies, BMI was measured pre-conception for 24 studies. 23 Twelve studies measured GWG. 34,35,37,[43][44][45][46]57,58,64,65,86 Of these, only one study mentioned the initial and last time points for weight measurements 46 while the last time point for measurement is not stated in other studies.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Increased maternal pregnancy complications in polycystic ovary syndrome appear to be independent of obesity—A systematic review, meta‐analysis, and meta‐regression

et al. 2019

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Summary Polycystic ovary syndrome (PCOS) is associated with an increased risk of maternal pregnancy and delivery complications. However, the impact of clinical features of PCOS and other potential risk factors in PCOS is still unknown. We aimed to investigate the association of PCOS with maternal pregnancy and delivery complications with consideration of risk factors and potential confounders. The meta‐analysis included 63 studies. PCOS was associated with higher miscarriage, gestational diabetes mellitus, gestational hypertension, pre‐eclampsia, induction of labour, and caesarean section. The association of PCOS with these outcomes varied by geographic continent, PCOS phenotypes, and study quality. Pre‐eclampsia and induction of labour were not associated with PCOS on body mass index‐matched studies. No outcome was associated with PCOS on assisted pregnancies. Age was significantly associated with higher miscarriage on meta‐regression. There were no studies assessing perinatal depression. We confirm that PCOS is associated with an increased risk of maternal pregnancy and delivery complications. The association of PCOS with the outcomes is worsened in hyperandrogenic PCOS phenotypes, in specific geographic continents, and in the highest quality studies but disappears in assisted pregnancies. Future studies in PCOS are warranted to investigate proper timing for screening and prevention of maternal pregnancy and delivery complications with consideration of clinical features of PCOS.

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Section: Search Resultsmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Increased maternal pregnancy complications in polycystic ovary syndrome appear to be independent of obesity—A systematic review, meta‐analysis, and meta‐regression

et al. 2019

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“…Studies regarding the impact of PCOS or PCOM on oocyte competence are conflicting [28][29][30][31][32][33]. Many factors could have been responsible on this contradiction such as ovulation induction program, patient age and ethnicity [34], and BMI.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy Outcomes in Infertile Women with Polycystic Ovaries following Intracellular Sperm Injection

2017

IJSR

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Polycystic ovary syndrome (PCOS) is a complex endocrine condition characterized by polycystic ovarian morphology (PCOM), oligo-or anovulation, and clinical or biochemical hyperandrogenism. Intracytoplamic sperm injection (ICSI) has been used extensively in treatment of infertile women with PCOS. In Iraq, pregnancy outcomes in PCOS patients following ICSI have yet to be evaluated. This study has therefore been conducted to define pregnancy outcomes in Iraqi PCOS patients as well as to define oocyte meiotic competence and normality following ovarian hyperstimulation. Although high doses of gonadotropin were used in infertile women with normal ovaries, the numbers of retrieved oocytes and estradiol peak levels were higher in patients with PCOM and PCOS than in patients with normal ovaries(P≤0.01). Wealso found that PCOM women have higher antral follicle count (AFC) than did PCOS women(P=0.0001). Moreover, significant high mean numbers of immature, mature, and degenerated oocytes were observed in PCOS and PCOM patients in comparison to those in control patient, which might be due to the high bulk of AFC and consequently higher numbers of oocyte recovered in PCOS or PCOM. As for ICSI outcomes, PCOS or PCOM patients had significantly higher fertilization, grade one embryo, embryo transfer and implantation, pregnancy, and live birth rates than did control patients. It is concluded that infertile women with PCOS or PCOM have higher pregnancy rates than do infertile women with unexplained or tubal-type infertility following ICSI.

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A comparison of the miscarriage rate between women with and without polycystic ovarian syndrome undergoing IVF treatment

Liu¹,

Tong²,

Jiang³

et al. 2014

European Journal of Obstetrics & Gynecology and Reproductiv

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Impact of Polycystic Ovary Syndrome on Selected Indicators of In Vitro Fertilization and Intracytoplasmic Sperm Injection Treatment Success

Abstract: Although IVF/ICSI yields more oocytes in the context of PCOS, IVF/ICSI outcomes do not differ significantly by PCOS status. Prospective cohort studies are needed to examine short-term and long-term health effects of PCOS in the context of IVF/ICSI.

Cited by 8 publications

References 33 publications

Increased maternal pregnancy complications in polycystic ovary syndrome appear to be independent of obesity—A systematic review, meta‐analysis, and meta‐regression

Increased maternal pregnancy complications in polycystic ovary syndrome appear to be independent of obesity—A systematic review, meta‐analysis, and meta‐regression

Pregnancy Outcomes in Infertile Women with Polycystic Ovaries following Intracellular Sperm Injection

A comparison of the miscarriage rate between women with and without polycystic ovarian syndrome undergoing IVF treatment

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