Impact of polymorphism in DNA repair genes OGG1 and XRCC1 on seminal parameters and human male infertility

Jalilvand, Amin; Karimi, Nazanin

doi:10.1111/and.13633

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…The mean age of case and control are 49 and 45, respectively. Of the 102 case 93% of the cases had squamous cell carcinoma (SCC) and 7% had adenocarcinomas, while the stages of cases were n=27 (26.5%) Stage I, n= 37 (36.27%) stage II, n=24(23.52%) Stage III, n=14(13.72%) Stage IV ( Jalilvand and Karimi, 2020;Hans et al, 2013). HPV infection in cases were 91(89.73%) whereas HPV negative cases were 9 (11.26%).…”

Section: Resultsmentioning

confidence: 99%

Association of DNA Repair Genes XRCC1 and APE-1 with the Risk of Cervical Cancer in North Indian population

Charles

Raza

Sharma

et al. 2020

Asian Pac J Cancer Prev

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Backgrounds: Cervical cancer (CC) is one of the leading cause of death in women worldwide, HPV infection is the major risk factor in the disease development, 0and however other risk factor such as chemical carcinogens, genetic susceptibility and altered immune system are also a cause of the disease progression. In the light of the above statement we studied the base excision repair pathway (BER). Methods: We identified and studied the association of Single Nucleotide polymorphisms in the DNA repair genes of XRCC1 ( Arg194Trp, Arg399G ,) and APE-1Asp/148Glu to the susceptibility of cervical cancer (CC) in North Indian population. In our study of cases (n=102). Controls (n=109) were recruited from among women without cervical abnormalities. Genotypes were determined by PCR-CTPP method, Taking DNA from peripheral blood in a case control study. Results: A positive association was observed between the polymorphisms of XRCC1 genes, that is, in codons 194 (P=0.03, odds ratio (OR) =2.39, 95% confidence interval (CI)=5.2–1.1), 280 (P=0.01, OR=4.1, 95% CI=11.5–1.3) and 399 (P=0.01, OR=3.4, 95% CI=8.6–1.3) while APE-1 genotype GG (p=0.03,odds ratio(OR)=0.2,95% confidence interval (CI)=0.97-0.004) we observed a statistically significant protective role in developing cervical cancer. Conclusion: Our results suggested that, XRCC1 gene is an important candidate gene for susceptibility to cervical cancer. Although the sample size was small, the present study indicate a statistical association between cervical cancer and XRCC1 SNPs . Future studies are needed that may provide a better understanding of the association between gene polymorphism and cervical carcinoma risk.

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Section: Resultsmentioning

confidence: 99%

Association of DNA Repair Genes XRCC1 and APE-1 with the Risk of Cervical Cancer in North Indian population

Charles

Raza

Sharma

et al. 2020

Asian Pac J Cancer Prev

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“…Studies conducted on diseases other than cancer have yielded con icting results. In studies involving patients diagnosed with rheumatoid arthritis, Parkinson's disease, infertility, diabetes, and hypertension, no association was found between OGG1 Ser326Cys polymorphism and the risk of these diseases [28][29][30][31][32]. However, a correlation was identi ed between cataract disease, chronic obstructive pulmonary disease, and OGG1 Ser326Cys polymorphism [33,34].…”

Section: Discussionmentioning

confidence: 99%

Investigation of the association between polymorphisms in DNA repair enzymes and STEMI

Güven

Çitak

Malikova

et al. 2023

Preprint

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Background: STEMI (ST-elevation myocardial infarction) is one of the most severe forms of coronary artery disease, known to significantly contribute to DNA damage. There are very few publications in this field in the literature. In our study, we examined the association between four polymorphisms in repair enzymes (LIG4 Thr9Ile, XRCC6 promoter C-57G, XPA -4A/G, OGG1 Ser326Cys) involved in three distinct DNA repair mechanisms (NHEJ (non-homologous end joining), NER (nucleotide excision repair), and BER (base excision repair), and their impact on the risk of STEMI. Methods & Results: This study involved 185 patients diagnosed with STEMI and included 100 healthy controls. The genotyping of SNPs was conducted through the PCR-RFLP (Polymerase chain reaction-restriction fragment length polymorphism) method for the following variants: XRCC6 (rs2267437), XPA (rs1800975), LIG4 ( rs1805388), and OGG1 (rs1052133). No significant differences were observed in the genotype distributions of the XRCC6 and OGG1 variations between the control and patient groups. On the other hand, our findings indicate that individuals carrying the mutant G allele for XPA polymorphism and the mutant Tallele for LIG4 polymorphism are susceptible to STEMI. Conclusions: Our findings demonstrate the significance of NHEJ and NER DNA repair processes in the pathogenesis of STEMI, as evidenced by the observed relationship between LIG4 and XPA polymorphisms.

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Investigation of the association between polymorphisms in DNA repair enzymes and STEMI

Raimoglou,

Cimci,

Citak

et al. 2024

Human Gene

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Impact of polymorphism in DNA repair genes OGG1 and XRCC1 on seminal parameters and human male infertility

Cited by 3 publications

References 2 publications

Association of DNA Repair Genes XRCC1 and APE-1 with the Risk of Cervical Cancer in North Indian population

Association of DNA Repair Genes XRCC1 and APE-1 with the Risk of Cervical Cancer in North Indian population

Investigation of the association between polymorphisms in DNA repair enzymes and STEMI

Investigation of the association between polymorphisms in DNA repair enzymes and STEMI

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