2022
DOI: 10.3390/ijms23147708
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Impact of Polypyridyl Ru Complexes on Angiogenesis—Contribution to Their Antimetastatic Activity

Abstract: The use of polypyridyl Ru complexes to inhibit metastasis is a novel approach, and recent studies have shown promising results. We have reported recently that Ru (II) complexes gathering two 4,7-diphenyl-1,10-phenanthroline (dip) ligands and the one being 2,2′-bipyridine (bpy) or its derivative with a 4-[3-(2-nitro-1H-imidazol-1-yl)propyl (bpy-NitroIm) or 5-(4-{4′-methyl-[2,2′-bipyridine]-4-yl}but-1-yn-1-yl)pyridine-2-carbaldehyde semicarbazone (bpy-SC) moieties can alter the metastatic cascade, among others, … Show more

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Cited by 2 publications
(3 citation statements)
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“…However, this effect seems to be mainly related to an extracellular action, being NAMI-A able to interact with collagen and inhibit the matrix metalloproteinases MMP-2 and MMP-9 without disclosing a significant ability to enter cells [ 49 ]. In compliance, other Ru-based derivatives, such as some arene ruthenium(II) complexes, have more recently demonstrated to be active directly on MDA-MB-231 triple-negative cells, exerting a suppressive action on metastases via AKT signal pathway inhibition and significantly reducing cell migration, invasiveness, and adhesion, as well as angiogenesis [ 50 , 51 , 52 ]. In a broad overview, these pieces of evidence endorse Ru-based complexes to act as multimodal functional agents by inhibiting tumor proliferation as well as migration, invasion, and metastasis formation [ 7 , 8 , 34 , 40 , 53 ].…”
Section: Discussionmentioning
confidence: 99%
“…However, this effect seems to be mainly related to an extracellular action, being NAMI-A able to interact with collagen and inhibit the matrix metalloproteinases MMP-2 and MMP-9 without disclosing a significant ability to enter cells [ 49 ]. In compliance, other Ru-based derivatives, such as some arene ruthenium(II) complexes, have more recently demonstrated to be active directly on MDA-MB-231 triple-negative cells, exerting a suppressive action on metastases via AKT signal pathway inhibition and significantly reducing cell migration, invasiveness, and adhesion, as well as angiogenesis [ 50 , 51 , 52 ]. In a broad overview, these pieces of evidence endorse Ru-based complexes to act as multimodal functional agents by inhibiting tumor proliferation as well as migration, invasion, and metastasis formation [ 7 , 8 , 34 , 40 , 53 ].…”
Section: Discussionmentioning
confidence: 99%
“…There is a growing body of evidence that RPCs that contain the Ru(dip) 2 structural motif affect cellular adhesion, motility, and invasion: properties that are central to cancer metastasis. [62,67,[75][76][77][78] As of yet, there is no underlying hypothesis that explains this activity. As microtubule function is central to these properties, [79] we postulate that RPC induced misfunction of MTs provides a unifying theory consistent with these mobility affects and a lot of the reported RPC cytotoxicity.…”
Section: Discussionmentioning
confidence: 99%
“…There is one additional but important supporting inference that can be made about such RPCs being MTAs. There is a growing body of evidence that RPCs that contain the Ru(dip) 2 structural motif affect cellular adhesion, motility, and invasion: properties that are central to cancer metastasis [62,67,75–78] . As of yet, there is no underlying hypothesis that explains this activity.…”
Section: Discussionmentioning
confidence: 99%