Impact of poorly controlled epilepsy in the Republic of Guinea

Jang, Minyoung; Sakadi, Foksouna; Tassiou, Nana Rahamatou; Abass, Cissé Fodé; Grundy, Sara J.; Woga, Arcer; Kenda, Bah Aissatou; Lamine, Condé M.; Talibé, B. Amadou; Qiu, Hongxiang; Cohen, Jerome Alan; Carone, Marco; Mateen, Farrah J.

doi:10.1016/j.seizure.2018.07.018

Cited by 22 publications

(18 citation statements)

References 29 publications

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“…In Guinea, despite the results obtained in the epilepsy study project [12][13][14][15][16], it remains a significant health problem, especially in the etiological aspects, including Rasmussen syndrome has never been mentioned. The same is true for other studies concerning the aetiology of epilepsy in Africa [17][18][19][20], in which a few cases have been reported.…”

Section: Discussionmentioning

confidence: 99%

Rasmussen syndrome in a tropical environment: a study of six (6) observations

Guelngar

Lamine

Ciré

et al. 2021

Egypt J Neurol Psychiatry Neurosurg

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Background In sub-Saharan Africa, encephalitis of various etiologies is a major public health problem and Rasmussen syndrome is rarely diagnosed due to under-medicalization. The objective of this study is to describe the clinical and neuroradiological forms, especially since this affection is little known in sub-Saharan Africa as evidenced by the scarcity of publications. Results A retrospective, descriptive and analytical study of six (6) cases of Rasmussen syndrome, shows that it is an unrecognized disease in Africa. Men were more represented with a frequency of 67% with a young age. The clinical picture dominated by 100% seizures, mental deterioration and hemiparesis. The etiology is still questionable, probably autoimmune in our study. Conclusion Rasmussen syndrome accounts for 3% in 219 patients hospitalized for epileptic conditions. This study shows a clinical profile dominated by recurrent epileptic seizures refractory to the drugs Phenobarbital, Valproic Acid and Carbamazepine, the only antiepileptics available in the country. These results are valid for therapeutic and prognostic discussion.

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Section: Discussionmentioning

confidence: 99%

Rasmussen syndrome in a tropical environment: a study of six (6) observations

Guelngar

Lamine

Ciré

et al. 2021

Egypt J Neurol Psychiatry Neurosurg

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“…Penelitian Niriayo et al (2018) menunjukkan bahwa lebih dari 50% pasien epilepsi tetap mengalami kekambuhan kejang, meskipun dengan penggunaan OAE yang optimal. Buruknya kontrol terhadap epilepsi dapat menyebabkan resiko tinggi hingga menyebabkan kematian akibat status epileptikus, sudden unexpected death in epilepsy (SUDEP), dan cedera yang tidak disengaja (Jang et al, 2018). Hasil ini berbeda dari penelitian lain yang menyatakan bahwa sebagian besar pasien (75.7%) mendapatkan keberhasilan terapi setelah menggunakan OAE (Andrianti, Gunawan and Hoesin, 2016).…”

Section: Pendahuluanunclassified

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Ilma¹,

Endriastuti²,

Suryoputri³

2021

Acta Pharm Indo

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Epilepsi merupakan penyakit kronis dengan prevalensi tinggi pada pediatrik. Salah satu obat anti epilepsi yang banyak diresepkan pada pediatrik adalah asam valproat. Luaran klinis utama pengobatan anti epilepsi adalah tercapainya periode bebas kejang. Tercapainya luaran klinis epilepsi sulit diprediksi karena dipengaruhi oleh banyak faktor. Penelitian ini bertujuan untuk menganalisis faktor-faktor yang berhubungan dengan luaran klinis pasien epilepsi pediatrik yang menggunakan asam valproat. Pengambilan data dilakukan melalui wawancara kepada orangtua/wali pasien. Epilepsi dikatakan terkontrol jika tercapai periode bebas kejang ≥6 bulan selama menggunakan asam valproat. Analisis data dilakukan dengan uji chi square atau uji Fisher, dilanjutkan dengan uji regresi logistik binomial. Pasien pada penelitian ini berjumlah 39 pasien. Sebagian besar pasien pediatri (64.1%) yang menggunakan terapi asam valproat memiliki epilepsi yang terkontrol, dengan 20 pasien (51.3%) menggunakan monoterapi asam valproat. Faktor yang berhubungan dengan luaran klinis pasien adalah jumlah obat antiepilepsi yang digunakan (p-value <0.05). Meskipun demikian, epilepsi yang tidak terkontrol dapat menjadi penyebab pasien diberikan politerapi.

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“…Encephalitis is marked by alteration of consciousness, seizures and fever. Where studied, the range of identified pathogens leading to encephalitis is high, with more than 100 pathogens identified in systematic reviews [9]. However, up to half of encephalitis cases remain undiagnosed by aetiology [10].…”

Section: Introductionmentioning

confidence: 99%

Encephalitis and meningitis in Western Africa: a scoping review of pathogens

Rezaei

Mateen

2021

Tropical Med Int Health

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Objective To give an overview of the recently reported literature on the aetiologies of meningitis and encephalitis in western sub‐Saharan Africa. Methods We conducted a scoping review following PRISMA guidance on published meningitis and encephalitis cases in the 16 countries of the United Nations‐defined western sub‐Saharan African region as identified in cohort studies, case series, and case reports, published 01/01/2000–08/01/2020, and available in four databases in August 2020 with an abstract in English, French or Italian. Results There were 38 distinct pathogens identified from 91 cohort studies’ data and 48 case reports or case series’ data. In cohort‐level data, the majority of cases were caused by Neisseria meningitidis (71.5%), Streptococcus pneumoniae (17.6%) and Haemophilus influenzae (7.3%). In case report‐ and case series‐level data, 40.5% of patients were <18 years old, 28.6% were female, and 28.6% were known to be immunocompromised. The case fatality rate was 39.3%. The most commonly reported pathogens among immunocompetent patients were Salmonella species (13 cases) and Ebola virus (9 cases), and the most commonly reported pathogen among immunocompromised patients was Cryptococcus neoformans (18 cases). Most cohort cases (52.3%) derived from Niger followed by Burkina Faso (28.6%). Most cases from single reports or series were reported from Nigeria (21.4%), Mali (20.2%) and Burkina Faso (19.0%). Conclusions Given the small number of pathogens reported, our findings underscore the need to better screen, diagnose and monitor populations in western sub‐Saharan Africa for additional CNS pathogens, including those posing significant outbreak risks.

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Impact of poorly controlled epilepsy in the Republic of Guinea

Cited by 22 publications

References 29 publications

Rasmussen syndrome in a tropical environment: a study of six (6) observations

Rasmussen syndrome in a tropical environment: a study of six (6) observations

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Encephalitis and meningitis in Western Africa: a scoping review of pathogens

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