Impact of porosity and surface functionalization of hard templates on the preparation of mesoporous silica microspheres

Fait, Fabio; Steinbach, Julia C.; Kandelbauer, Andreas; Mayer, Hermann A.

doi:10.1016/j.micromeso.2023.112482

Cited by 6 publications

(12 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This trend fits well with the observations made in the statistical evaluation of the process factor effects n (H 2 O)/ n (TEOS) and c(NH 3 ). This offers more space within the template pores for aggregation of in situ formed highly reactive small silica species und consequently larger SNPs . In combination with the higher template pore volume, more and larger SNPs were incorporated into the template.…”

Section: Resultsmentioning

confidence: 99%

“…Thus, although the sol–gel parameters were the same for MPSM-C 18 -1 as MPSM2 and for MPSM-C 18 -2 as the CP s the materials differ slightly. This is a result from changes in the template characteristics and scale up . Interestingly, the template with the higher pore volume, larger pores, and higher SSA resulted in MPSMs with lower pore volumes and lower SSA but enlarged pore sizes.…”

Section: Resultsmentioning

confidence: 99%

“…The introduction of meso-/macropores allows a good effective accessibility of the porous material for diffusion-controlled processes . Templating methods have been widely applied to prepare porous silica materials with tunable size and pore characteristics. − While soft templates are successfully used to prepare nanometer-sized silica particles, ,, hard templates are the choice to synthesize micrometer-sized mesoporous silica spheres (MPSMs). , This is because hard templates such as poly(glycidyl methacrylate- co -ethylene glycol dimethacrylate) particles ( p (GMA- co -EDMA)) ,− are usually formative, i.e., determining the three-dimensional morphology. ,, Template-assisted methods for the preparation of MPSMs consist usually of three sequential steps: − (a) synthesis of the formative template, , (b) synthesis and/or incorporation of silica into the template, , and (c) subsequent removal of the template , (Figure ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sol–Gel-Controlled Size and Morphology of Mesoporous Silica Microspheres Using Hard Templates

et al. 2023

Self Cite

View full text Add to dashboard Cite

Mesoporous silica microspheres (MPSMs) represent a promising material as a stationary phase for HPLC separations. The use of hard templates provides a preparation strategy for producing such monodisperse silica microspheres. Here, 15 MPSMs were systematically synthesized by varying the sol−gel reaction parameters of water-to-precursor ratio and ammonia concentration in the presence of a porous p(GMA-co-EDMA) polymeric hard template. Changing the sol−gel process factors resulted in a wide range of MPSMs with varying particle sizes from smaller than one to several micrometers. The application of response surface methodology allowed to derive quantitative predictive models based on the process factor effects on particle size, pore size, pore volume, and specific surface area of the MPSMs. A narrow size distribution of the silica particles was maintained over the entire experimental space. Two larger-scale batches of MPSMs were prepared, and the particles were functionalized with trimethoxy(octadecyl) silane for the application as stationary phase in reversed-phases liquid chromatography. The separation of proteins and amino acids was successfully accomplished, and the effect of the pore properties of the silica particles on separation was demonstrated.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Sol–Gel-Controlled Size and Morphology of Mesoporous Silica Microspheres Using Hard Templates

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…The preparation of mesoporous silica microspheres (MPSMs) with narrow size distributions remains challenging [35][36][37][38][39][40]. Recently, for the synthesis of MPSMs, a promising protocol has been developed that employs functionalized porous poly (glycidyl methacrylateco-ethylene glycol dimethacrylate) polymer particles (p(GMA-co-EDMA)) as hard templates in the presence of the basic hydrolysis and condensation of TEOS [35].…”

Section: Introductionmentioning

confidence: 99%

“…The best matches of the templates are achieved if the rate of the growth of the SNPs and their rate of diffusion into the template pores are well balanced. Moreover, the particle and pore properties correlate with the size of the SNPs, which depends on the sol-gel conditions (see above) and the template [39,40].…”

Section: Introductionmentioning

confidence: 99%

Tailoring the Morphology of Monodisperse Mesoporous Silica Particles Using Different Alkoxysilanes as Silica Precursors

Fait

Wagner

Steinbach

et al. 2023

IJMS

Self Cite

View full text Add to dashboard Cite

The hard template method for the preparation of monodisperse mesoporous silica microspheres (MPSMs) has been established in recent years. In this process, in situ-generated silica nanoparticles (SNPs) enter the porous organic template and control the size and pore parameters of the final MPSMs. Here, the sizes of the deposited SNPs are determined by the hydrolysis and condensation rates of different alkoxysilanes in a base catalyzed sol–gel process. Thus, tetramethyl orthosilicate (TMOS), tetraethyl orthosilicate (TEOS), tetrapropyl orthosilicate (TPOS) and tetrabutyl orthosilicate (TBOS) were sol–gel processed in the presence of amino-functionalized poly (glycidyl methacrylate-co-ethylene glycol dimethacrylate) (p(GMA-co-EDMA)) templates. The size of the final MPSMs covers a broad range of 0.5–7.3 µm and a median pore size distribution from 4.0 to 24.9 nm. Moreover, the specific surface area can be adjusted between 271 and 637 m2 g−1. Also, the properties and morphology of the MPSMs differ according to the SNPs. Furthermore, the combination of different alkoxysilanes allows the individual design of the morphology and pore parameters of the silica particles. Selected MPSMs were packed into columns and successfully applied as stationary phases in high-performance liquid chromatography (HPLC) in the separation of various water-soluble vitamins.

show abstract

Imidazole-octyl mixed-mode stationary phase based on macroporous silica for the purification of ovomucoid and ovotransferrin

Guo,

Bai,

Chen

2023

Microchim Acta

View full text Add to dashboard Cite

Impact of porosity and surface functionalization of hard templates on the preparation of mesoporous silica microspheres

Cited by 6 publications

References 35 publications

Sol–Gel-Controlled Size and Morphology of Mesoporous Silica Microspheres Using Hard Templates

Sol–Gel-Controlled Size and Morphology of Mesoporous Silica Microspheres Using Hard Templates

Tailoring the Morphology of Monodisperse Mesoporous Silica Particles Using Different Alkoxysilanes as Silica Precursors

Imidazole-octyl mixed-mode stationary phase based on macroporous silica for the purification of ovomucoid and ovotransferrin

Contact Info

Product

Resources

About