Soybean [Glycine max (L.) Merr.] cultivars resistant to synthetic auxin herbicides have provided another mode of action for the postemergence broadleaf weed control. This field study was conducted at three South Dakota locations [Northeast, NERF; east-central, ARF; and Southeast, SERF) in 2019 and two locations (ARF and SERF) in 2020. The Enlist E3 and Roundup Ready 2 Xtend cultivars were planted at three dates (early, mid-, and late season) to examine weed control, agronomic characteristics, nodulation, and yield. Preemergence (PRE) treatment was flumioxazin + metribuzin + S-metolachlor + glyphosate + pendimethalin. Two postemergence (POST) treatments, based on cultivar, were compared with PRE-only. The PREonly treatment had numerous grasses {including green foxtail [Setaria viridis (L.) P. Beauv.] and yellow foxtail [S. pumila (Poir.) Roem. & Schult.], volunteer corn (Zea mays L.), barnyard grass [Echinochola crus-galli (L.) Beauv.], large crabgrass [Digitaria sanguinalis (L.) Scop.], woolly cupgrass [Eriochloa villosa (Thunb.) Kunth]} and broadleaf weeds (including redroot pigweed [Amaranthus retroflexus L.], common lambsquarters [Chenopodium album L.], waterhemp [Amaranthus rudis Sauer])with high density and biomass. POST treatments controlled most of the broadleaf species, although some grasses remained. Yields were similar within a location and year, although differences occurred among planting dates. In 2019, planting date did not influence final yield at ARF (average yield 3,084 kg ha −1 ). Yield was greatest for the early (NERF) and mid-planting dates (NERF and SERF) compared with late-season planting. In 2020, dry conditions occurred, and yields at ARF and SERF were lowest for the late-season plantings (ranging from 37 to 73% lower depending on cultivar) compared with the early season planting. In 2020, dicamba + glyphosate