Impact of Postoperative Pneumonia Developing After Discharge on Long‐Term Follow‐up for Resected Lung Cancer

Shinohara, Shuichi; Sugaya, Masakazu; Onitsuka, Takamitsu; Machida, Kazuhiko; Matsuo, Masaki; Tanaka, Fumihiro

doi:10.1007/s00268-018-4727-2

Cited by 8 publications

(2 citation statements)

References 47 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cancer patients are at a higher risk of drug-drug interactions (DDIs), because they usually take multiple medications. Moreover, the majority of cancer patients are elderly individuals who require additional medications due to comorbidities (Riechelmann et al, 2007;Targownik et al, 2007;Shinohara et al, 2018;Herrmann, 2020). Studies have shown that 0.6-5% of hospitalizations related to adverse drug events (ADEs) are because of drug interactions, which is generally believed to account for a significant proportion of ADEs (Becker et al, 2007;Roughead et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Potentially Hazardous Drug-Drug Interactions Associated With Oral Antineoplastic Agents Prescribed in Chinese Tertiary Care Teaching Hospital Settings: A Multicenter Cross-Sectional Study

et al. 2022

View full text Add to dashboard Cite

Background: Oral administration increases the risk of interactions, because most oral antineoplastic agents (OAAs) are taken on a daily basis. Interactions can increase exposure to antitumoral agents or cause treatment failure. Potential drug–drug interactions (DDIs) are commonly observed in patients with cancer, while the extent to which OAAs related hazardous DDIs remains unclear.Methods: We studied the contraindication patterns between oral antineoplastic agents and other medications among cancer patients in two tertiary care teaching hospitals in China. A total of 20 clinically significant hazardous DDI pairs that involved 30 OAAs were identified based on the predetermined criteria. Patient medications were checked for DDIs by using the US Food and Drug Administration approved labeling. Descriptive statistics and uni- and multivariate logistic regression analyses were carried out.Results: In this study, 13,917 patients were included and a total of 297 DDIs were identified. The results revealed that proton pump inhibitors (PPIs), dexamethasone and fluoroquinolones were the most often involved hazardous DDIs with OAAs. The most prevalent contraindication is the simultaneous use of certain molecular targeted agents and PPIs. In the result of the multivariate analysis, younger age (0–20 group), increasing number of drugs and patient treated with targeted therapy had a higher risk for DDIs.Conclusion: The prevalence of OAAs related hazardous DDIs appears to be low in the cancer patients. However, physicians and clinical pharmacologists should be aware of the potential hazardous DDIs when prescribing OAAs, especially certain pH-dependent molecular targeted agents and potential QTc prolonging drugs.

show abstract

Section: Introductionmentioning

confidence: 99%

Potentially Hazardous Drug-Drug Interactions Associated With Oral Antineoplastic Agents Prescribed in Chinese Tertiary Care Teaching Hospital Settings: A Multicenter Cross-Sectional Study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Furthermore, in patients with advanced lung cancer who have had lung resection, CAP is a serious and often lifethreatening condition. [6][7][8] The rate of postoperative bacterial pneumonias remains high and may confer an increased risk of metastasis. 9 During the initial management of a patient with CAP, it is crucial to identify possible risk factors and empirical antimicrobial treatments, as the causative pathogen is unknown.…”

Section: Introductionmentioning

confidence: 99%

<p>Etiology of Community-Acquired Pneumonia Requiring Hospital Admission in Adults with and Without Cancers: A Single-Center Retrospective Study in China</p>

Wang

Zhang

et al. 2020

IDR

View full text Add to dashboard Cite

Background: The etiology and distribution of community-acquired pneumonia (CAP) vary periodically and geographically. The clinical evaluation of CAP among patients with cancers remains unknown. Patients and Methods: This retrospective hospital-based study on adult CAP was conducted in Tang Du Hospital, China, from September 2018 to August 2019. The demographic characteristics, clinical manifestations and laboratory data were extracted from medical records and compared between CAP patients with and without cancers. Univariable and multivariable logistic regression methods were used to explore risk factors associated with CAP patients with and without cancers. Results: Data from 149 CAP patients with cancers and 268 CAP patients without cancers were analyzed. Patients without cancers were more likely to show fever, cough and yellow sputum, higher level of neutrophil count than the cancer patients. Klebsiella pneumoniae (K. pneumoniae 14.77% vs 9.33%, p = 0.093) and Streptococcus pneumoniae (S. pneumoniae 16.11% vs 11.57%, p = 0.189) were among the most commonly encountered pathogens in both the groups. Pseudomonas aeruginosa (P. pneumoniae 26.50% vs 11.41%, p < 0.001), Mycoplasma pneumoniae (M. pneumoniae 8.21% vs 1.34%, p = 0.003), and filamentous fungi (10.82% vs 4.7%, p = 0.033) were predominant in CAP patients without cancers. Haemophilus influenzae (H. influenzae 22.15% vs 14.18%, p = 0.038) and methicillin-resistant Staphylococci (MRS 23.49 vs 15.68, p = 0.049) were more prevalent for CAP cancer patients. Certain pathogens were increasing in a cold season. In patients without cancers, MRS, H. influenzae and P. aeruginosa were associated with central nervous system (CNS) disease, connective tissue disease, bronchiectasis, respectively. In addition, healthy adults were likely to be infected with M. pneumoniae showing fever. Conclusion: CAP patients with cancers had atypical clinical manifestations and showed no distinct increase in inflammatory markers. The predominant pathogens differed as well as similar between the CAP patients with and without cancers. Certain pathogens follow a seasonal pattern. CNS disease, connective tissue disease and bronchiectasis were associated with the predominant pathogens in patients without cancers.

show abstract

The Prognostic Impact of Pericardial Fat Volumes in Resected Non-small Cell Lung Cancer

et al. 2019

View full text Add to dashboard Cite

Impact of Postoperative Pneumonia Developing After Discharge on Long‐Term Follow‐up for Resected Lung Cancer

Abstract: Our findings revealed a high incidence and mortality of PDAD among patients who had undergone lung resection with long-term follow-up. Therefore, PDAD could be associated with poorer overall survival.

Cited by 8 publications

References 47 publications

Potentially Hazardous Drug-Drug Interactions Associated With Oral Antineoplastic Agents Prescribed in Chinese Tertiary Care Teaching Hospital Settings: A Multicenter Cross-Sectional Study

Potentially Hazardous Drug-Drug Interactions Associated With Oral Antineoplastic Agents Prescribed in Chinese Tertiary Care Teaching Hospital Settings: A Multicenter Cross-Sectional Study

<p>Etiology of Community-Acquired Pneumonia Requiring Hospital Admission in Adults with and Without Cancers: A Single-Center Retrospective Study in China</p>

The Prognostic Impact of Pericardial Fat Volumes in Resected Non-small Cell Lung Cancer

Contact Info

Product

Resources

About