2018
DOI: 10.3748/wjg.v24.i13.1429
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Impact of postoperative TNM stages after neoadjuvant therapy on prognosis of adenocarcinoma of the gastro-oesophageal junction tumours

Abstract: AIMTo compare prognostic relevance of postoperative tumour/node/metastasis (TMN) stages between patients with and without neoadjuvant treatment.METHODSData from patients with adenocarcinoma of the gastro-oesophageal junction (AEG) who had undergone surgical resection at a single German university centre were retrospectively analysed. Patients with or without neoadjuvant preoperative treatment were selected by exact matching based on preoperative staging. Standard assessment of preoperative (c)TNM stage was bas… Show more

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“…There is little literature on the applicability of the UICC classification for patients undergoing neoadjuvant treatments. A previous study on gastro-esophageal tumors has addressed the same issue, showing that the UICC classification was applicable to patients undergoing neoadjuvant treatment and that, as in previous studies, downstaging of lymph nodes provides a decisive survival advantage [ 21 ]. Another recent study was able to underline the effect of downstaging by neoadjuvant therapy, showing that patients in stage III without evidence of positive lymph nodes in the histopathological findings have a significantly better survival [ 13 ].…”
Section: Discussionmentioning
confidence: 95%
“…There is little literature on the applicability of the UICC classification for patients undergoing neoadjuvant treatments. A previous study on gastro-esophageal tumors has addressed the same issue, showing that the UICC classification was applicable to patients undergoing neoadjuvant treatment and that, as in previous studies, downstaging of lymph nodes provides a decisive survival advantage [ 21 ]. Another recent study was able to underline the effect of downstaging by neoadjuvant therapy, showing that patients in stage III without evidence of positive lymph nodes in the histopathological findings have a significantly better survival [ 13 ].…”
Section: Discussionmentioning
confidence: 95%