Impact of pre‐operative statin use on risk of mortality and early atrial fibrillation after heart transplantation

Krishnan, Balaji; Vakil, Kairav; Sankar, Ashwini; Duprez, Daniel; Benditt, David G.

doi:10.1111/ctr.12729

Cited by 9 publications

(3 citation statements)

References 23 publications

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“…The final analysis included 18 articles, including 2 study cohorts from clinical trials and 16 cohort studies with 5393 heart transplant recipients were enrolled. The literature retrieval, review, and selection process are demonstrated in Figure .…”

Section: Resultsmentioning

confidence: 99%

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Atrial fibrillation following heart transplantation: A systematic review and meta‐analysis of observational studies

Chokesuwattanaskul

Preechawat

O'Corragain

et al. 2018

J Evidence Based Medicine

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Objective: Previous studies have suggested a high incidence of atrial fibrillation (AF) in heart transplant recipients. However, incidence trends of AF in heart transplant recipients remain unclear. The study's aims were (1) to investigate the pooled incidence/incidence trends of AF following heart transplantation and (2) to assess the mortality risk of heart transplant recipients with AF. Methods:A literature search for studies that reported the incidence of AF following heart transplantation was conducted using MEDLINE, EMBASE, and The Cochrane Database from inception through March 2018. Pooled incidence and odds ratios (OR) with 95%CI were calculated using a random-effects model. Results:Eighteen studies (2 cohorts from clinical trials and 16 cohort studies) with 5393 heart transplant recipients were enrolled. The pooled estimated incidence of AF in heart transplant was 10.1% (95%CI: 7.6%-13.2%). Meta-analysis based on the type of anastomotic technique demonstrated a pooled estimated incidence of AF following heart transplantation of 18.7% (95%CI: 10.3%-31.5%) and 11.1% (95%CI: 6.5%-18.4%) by biatrial and bicaval techniques, respectively.There was a significant association between AF following a heart transplant and increased mortality risk with a pooled OR of 2.86 (95%CI: 2.08-3.93). Meta-regression analyses showed no significant correlations between the year of study and incidence of AF (P = 0.47) or mortality risk of AF after heart transplantation (P = 0.99). Conclusions:The overall estimated incidence of AF following heart transplantation is 10.1%.There is a significant association between AF and increased mortality after transplantation. Furthermore, incidence and mortality risk of AF following heart transplant does not seem to decrease over time. K E Y W O R D Satrial fibrillation, cardiac, heart, meta-analysis, transplant, transplantation is almost 90% with a median survival rate over 10 years. [2][3][4]

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Section: Resultsmentioning

confidence: 99%

“…The literature retrieval, review, and selection process are demonstrated in Figure . The characteristics and quality assessment of the included studies are presented in Table …”

Section: Resultsmentioning

confidence: 99%

Atrial fibrillation following heart transplantation: A systematic review and meta‐analysis of observational studies

Chokesuwattanaskul

Preechawat

O'Corragain

et al. 2018

J Evidence Based Medicine

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“…However, data on the influence of pre-operative statin therapy in heart transplant surgery are lacking. A recent retrospective study on the influence of pre-transplant statin treatment on clinical outcomes after heart transplantation indicated that pre-operative statin therapy does not seem to influence the risk of mortality or early POAF after heart transplantation (Krishnan et al, 2016). These are preliminary findings, which should be confirmed by further large-scale prospective clinical studies.…”

Section: Statins In Postoperative Afmentioning

confidence: 89%

Statins and atrial fibrillation - mini - review on recent evidence

Sosnowska¹,

Banach²

2017

Heart Beat

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Optimizing Outcomes in Heart Transplantation: The Role of High‐Intensity Statin Therapy

Ghavamikia,

Saffarfar,

Seifdavati

et al. 2024

J Biochem & Molecular Tox

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Heart transplantation is a vital procedure for patients with end‐stage heart failure, but it faces significant challenges, including graft dysfunction, rejection, and cardiac allograft vasculopathy (CAV), which can compromise long‐term graft success. Research suggests that statin therapy may offer significant benefits to heart transplant recipients, such as improved long‐term survival and reduced rates of graft rejection and mortality. The aim of this review is to thoroughly examine the recent literature on this topic since 2005. Early use of high‐dose statins appears to be particularly effective in preventing vasculopathy and improving outcomes, although a titrated approach may help to reduce side effects. High‐dose statins may provide superior cardiovascular benefits, including lower rates of CVD, slower progression of CVD and improved long‐term graft survival. Despite potential concerns about adverse effects, evidence suggests that high‐intensity statins improve cholesterol levels without increasing serious adverse events after transplantation. The goal of statin therapy in heart transplant recipients is to balance the well‐established benefits seen in the general population with the specific needs of this group, with the ultimate goal of improving both longevity and quality of life.

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Impact of pre‐operative statin use on risk of mortality and early atrial fibrillation after heart transplantation

Abstract: Pre-operative statin therapy does not seem to influence the risk of mortality or early post-operative AF after HT. Future large-scale studies are required to validate these preliminary findings.

Cited by 9 publications

References 23 publications

Atrial fibrillation following heart transplantation: A systematic review and meta‐analysis of observational studies

Atrial fibrillation following heart transplantation: A systematic review and meta‐analysis of observational studies

Statins and atrial fibrillation - mini - review on recent evidence

Optimizing Outcomes in Heart Transplantation: The Role of High‐Intensity Statin Therapy

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