2021
DOI: 10.1080/16078454.2021.1872957
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Impact of pre-transplant use of antibiotics on the graft-versus-host disease in adult patients with hematological malignancies

Abstract: Objectives: Changes in fecal microbiota affect the incidence and extent of graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). Most patients with hematological malignancies receive antibiotics for the treatment of febrile neutropenia prior to allogeneic HSCT, and pre-transplant use of antibiotics may influence the fecal microbiota and GVHD. Methods: We retrospectively analysed consecutive adult patients with hematological malignancies who received allogeneic HSCT a… Show more

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Cited by 4 publications
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“…Patients within an allo‐HCT setting are frequently exposed to anti‐infective therapy as it was also the case in the majority of our patients (see above). Especially the duration and amount of antibiotic therapy has been linked to the overall outcome after allo‐HCT, but also to the onset and course of a‐GvHD 83‐86 . Of note, only two out of six patients (K_006 + K_008) received antibiotic therapy until d‐1 pre‐FMT; at the day of FMT (d0) 0/6 and until day 7 post‐FMT, only 1/6 patients (K_008) received antibiotic therapy (see above and Table ).…”
Section: Discussionmentioning
confidence: 99%
“…Patients within an allo‐HCT setting are frequently exposed to anti‐infective therapy as it was also the case in the majority of our patients (see above). Especially the duration and amount of antibiotic therapy has been linked to the overall outcome after allo‐HCT, but also to the onset and course of a‐GvHD 83‐86 . Of note, only two out of six patients (K_006 + K_008) received antibiotic therapy until d‐1 pre‐FMT; at the day of FMT (d0) 0/6 and until day 7 post‐FMT, only 1/6 patients (K_008) received antibiotic therapy (see above and Table ).…”
Section: Discussionmentioning
confidence: 99%