Impact of prediagnostic smoking and smoking cessation on colorectal cancer prognosis: a meta-analysis of individual patient data from cohorts within the CHANCES consortium

Ordóñez‐Mena, José M.; Walter, Viola; Schöttker, Ben; Jenab, Mazda; O’Doherty, Mark G.; Kee, Frank; Bueno‐de‐Mesquita, Bas; Peeters, Petra H.; Stricker, Bruno H.; Ruiter, Rikje; Hofman, Albert; Söderberg, Stefan; Jousilahti, Pekka; Kuulasmaa, Kari; Freedman, Neal D.; Wilsgaard, Tom; Wolk, Alicja; Nilsson, Lena; Tjønneland, Anne; Quiŕos, J. Ramón; Duijnhoven, Fränzel J.B. van; Siersema, Peter D.; Boffetta, Paolo; Trichopoulou, Antonia; Brenner, Hermann

doi:10.1093/annonc/mdx761

Cited by 65 publications

(63 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, our findings are in agreement with the results of a recent meta-analysis of 14 prospective cohort studies on prediagnostic smoking status and CRC survival 56. The authors found no association between prediagnostic former smoking (pooled HR=1.00, 95% CI 0.91 to 1.09) or current smoking (pooled HR=1.15, 95% CI 0.95 to 1.41) and CRC survival, but they did find an association with overall survival 56. While higher education has been noted as a predictor of healthy lifestyle57 58 and is inversely related to CRC incidence in the NOWAC cohort,59 we found no association between duration of education and CRC survival.…”

Section: Discussionsupporting

confidence: 93%

“…Nevertheless, a study using data from the CPS-II Nutrition Cohort found an association with prediagnostic current smoking but not former smoking 55. However, our findings are in agreement with the results of a recent meta-analysis of 14 prospective cohort studies on prediagnostic smoking status and CRC survival 56. The authors found no association between prediagnostic former smoking (pooled HR=1.00, 95% CI 0.91 to 1.09) or current smoking (pooled HR=1.15, 95% CI 0.95 to 1.41) and CRC survival, but they did find an association with overall survival 56.…”

Section: Discussionsupporting

confidence: 92%

“…Smoking is a well-known risk factor for many cancers, including CRC,51–53 and it has also been associated with overall mortality 54–56. Our study did not find any association between prediagnostic smoking status and CRC survival, although we observed an almost 100% increased risk of non-CRC death among participants who were current smokers prior to CRC diagnosis compared with never smokers.…”

Section: Discussioncontrasting

confidence: 74%

See 2 more Smart Citations

Competing mortality risks analysis of prediagnostic lifestyle and dietary factors in colorectal cancer survival: the Norwegian Women and Cancer Study

Oyeyemi

Br̈aaten

Skeie

et al. 2019

BMJ Open Gastroenterol

View full text Add to dashboard Cite

BackgroundIt remains unclear whether or which prediagnostic lifestyle and dietary factors influence colorectal cancer (CRC) survival following diagnosis. This study used competing mortality risks analysis to evaluate the association between these factors and CRC survival.MethodsA total of 96 889 cancer-free participants of the Norwegian Women and Cancer Study completed the study’s baseline questionnaire on lifestyle and dietary factors between 1996 and 2004. Of the 1861 women who subsequently developed CRC, 550 had CRC as the cause of death, while 110 had a non-CRC cause of death. We used multiple imputation to handle missing data. We performed multivariable competing mortality risks analyses to determine the associations between prediagnostic lifestyle and dietary factors and CRC survival. Cause-specific HRs were estimated by Cox regression and subdistribution HRs were estimated by the Fine-Gray regression with corresponding 95% CIs.ResultsFollowing multivariable adjustment, a prediagnostic vitamin D intake of >10 μg/day compared with ≤10 μg/day was associated with better CRC survival (HR=0.75, 95% CI 0.61 to 0.92). Other prediagnostic lifestyle and dietary factors showed no association with CRC survival. The corresponding results obtained from cause-specific Cox and Fine-Gray regressions were similar.ConclusionOur study shows that prediagnostic vitamin D intake could improve CRC survival.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 74%

See 1 more Smart Citation

Competing mortality risks analysis of prediagnostic lifestyle and dietary factors in colorectal cancer survival: the Norwegian Women and Cancer Study

Oyeyemi

Br̈aaten

Skeie

et al. 2019

BMJ Open Gastroenterol

View full text Add to dashboard Cite

show abstract

“…Although we did not evaluate mortality rates, previous studies suggested that smoking cessation is advisable to reduce mortality in patients with colon cancer [34][35][36], and benefits of smoking cessation increase over time [37]. Indeed, we observed that longer smoking cessation duration was associated with fewer complications.…”

Section: Discussionmentioning

confidence: 70%

Perioperative complications of abdominal surgery in smokers

et al. 2020

View full text Add to dashboard Cite

Purpose This study examined the association between smoking and perioperative complications of laparoscopic abdominal surgery and whether these complications were reduced with ≥ 4 weeks of preoperative smoking cessation. Methods A total of 555 patients who underwent gastric and colorectal cancer surgeries under general anesthesia were divided into the following groups retrospectively: 290 individuals without smoking history (NS group), 144 previous smokers (stopped smoking more than 8 weeks before surgery, PS group), and 121 current smokers (CS group) divided to two groups according to preoperative smoking cessation for < 4 (CS1, n = 76) and 4–8 weeks (CS2, n = 45). Results When compared with the NS group, postoperative hospitalization duration was significantly longer in the CS1 group (p < 0.01), whereas differences between the CS2 or PS groups and NS group were not significant. The total number of postoperative complications was higher in all groups of smoking than in NS group, independent on preoperative smoking cessation; however, suture failure was significantly more frequent only in CS1 group. Although pack-years did not significantly affect complication rates in smokers, duration of smoking cessation time in PS group was a negative predictor of postoperative complications. Conclusion Providing more than 4 weeks of smoking cessation before gastrointestinal surgery can reduce the duration of hospitalization and rate of suture failure.

show abstract

“…Regarding smoking, in our CC cohort, current and former SMK were also independent factors associated with shorter OS (Table 2). In CRC patients, current and former smoking at the time of diagnosis has been associated with shorter OS compared to never smoking [20][21][22]. Current smoking, but not former smoking, was associated with CSS in one study [22], and neither current nor former smoking was associated with CSS in another study [21].…”

Section: Discussionmentioning

confidence: 88%

Co-morbid risk factors and NSAID use among white and black Americans that predicts overall survival from diagnosed colon cancer

et al. 2020

View full text Add to dashboard Cite

Black Americans (BA) have higher incidence and higher mortality rates for colorectal cancers (CRC) as compared to White Americans (WA). While there are several identified risk factors associated with the development of CRC and evidence that high levels of adequate screening can reduce differences in incidence for CRC between BA and WA, there remains little data regarding patient co-morbid contributions towards survival once an individual has CRC. Here we set out to identify patient risk factors that influenced overall survival in a cohort of 293 BA and 348 WA with colon cancer. Amid our cohort, we found that patients' age, tobacco usage, and pre-diagnosed medical conditions such as hypertension and diabetes were associated with shorter overall survival (OS) from colon cancer. We identified pre-diagnosed hypertension and diabetes among BA were responsible for one-third of the colon cancer mortality disparity compared with WA. We also identified long-term regular use of non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, was associated with shorter OS from colon cancer among WA >65 years of age, but not younger WA patients or any aged BA patients. Our results raise the importance of not only treating the colon cancer itself, but also taking into consideration co-morbid medical conditions and NSAID usage to enhance patient OS. Further evaluation regarding adequate treatment of co-morbidities and timing of NSAID continuance after cancer therapy will need to be studied.

show abstract

Impact of prediagnostic smoking and smoking cessation on colorectal cancer prognosis: a meta-analysis of individual patient data from cohorts within the CHANCES consortium

Cited by 65 publications

References 38 publications

Competing mortality risks analysis of prediagnostic lifestyle and dietary factors in colorectal cancer survival: the Norwegian Women and Cancer Study

Competing mortality risks analysis of prediagnostic lifestyle and dietary factors in colorectal cancer survival: the Norwegian Women and Cancer Study

Perioperative complications of abdominal surgery in smokers

Co-morbid risk factors and NSAID use among white and black Americans that predicts overall survival from diagnosed colon cancer

Contact Info

Product

Resources

About