Impact of preeclampsia on ventricular repolarization indices

Duran, Mustafa; Zıyrek, Murat; Sertdemi̇r, Ahmet Lütfü; Günenç, Oğuzhan; Bardak, Ömer

doi:10.1016/j.jelectrocard.2021.08.020

Cited by 8 publications

(9 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…100 In patients treated with SGLT2 inhibitors as an add-on therapy to metformin, the QT interval was found to be shorter compared to patients treated with other glucose-lowering agents. 101 These findings support the potential use of SGLT2 inhibitors for the treatment of LQTS3.…”

Section: Long Qt Syndromesupporting

confidence: 62%

Impacts of gene variants on drug effects-the foundation of genotype-guided pharmacologic therapy for long QT syndrome and short QT syndrome

Zhao,

Zang,

Niu

et al. 2024

eBioMedicine

View full text Add to dashboard Cite

Section: Long Qt Syndromesupporting

confidence: 62%

Impacts of gene variants on drug effects-the foundation of genotype-guided pharmacologic therapy for long QT syndrome and short QT syndrome

Zhao,

Zang,

Niu

et al. 2024

eBioMedicine

View full text Add to dashboard Cite

“…By contrast, SGLT2 inhibitors have produced exciting results related to their potential anti-arrhythmic properties. In diabetic patients prescribed SGLT2 inhibitors instead of other diabetic medication in addition to metformin, Duran et al ( 86 ) observed beneficial alterations in ventricular repolarisation dispersion, which in turn is associated with the development of cardiac arrhythmias ( 87 ). SGLT2 inhibitors also interfere with redox signalling in cardiomyocytes, disruption of which can lead to atrial arrhythmias ( 88 ).…”

Section: The Role Of Non-aad Medication In Crt Arrhythmia Managementmentioning

confidence: 99%

Managing arrhythmia in cardiac resynchronisation therapy

de Vere,

Wijesuriya,

Elliott

et al. 2023

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Arrhythmia is an extremely common finding in patients receiving cardiac resynchronisation therapy (CRT). Despite this, in the majority of randomised trials testing CRT efficacy, patients with a recent history of arrhythmia were excluded. Most of our knowledge into the management of arrhythmia in CRT is therefore based on arrhythmia trials in the heart failure (HF) population, rather than from trials dedicated to the CRT population. However, unique to CRT patients is the aim to reach as close to 100% biventricular pacing (BVP) as possible, with HF outcomes greatly influenced by relatively small changes in pacing percentage. Thus, in comparison to the average HF patient, there is an even greater incentive for controlling arrhythmia, to achieve minimal interference with the effective delivery of BVP. In this review, we examine both atrial and ventricular arrhythmias, addressing their impact on CRT, and discuss the available evidence regarding optimal arrhythmia management in this patient group. We review pharmacological and procedural-based approaches, and lastly explore novel ways of harnessing device data to guide treatment of arrhythmia in CRT.

show abstract

“…[9] In a study comparing early onset preeclampsia (defined as <34 weeks at diagnosis), late onset pre-eclampsia (>34 weeks at diagnosis, and healthy controls, patients diagnosed earlier in their pregnancy had prolonged QT intervals compared to healthy patients. [10] Although these studies did not include patients with known cardiac disease, arrhythmias, or previous cardiac surgery, they do suggest a relationship between pre-eclampsia and structural cardiac changes that can predispose a patient to arrhythmia. In our population, these structural changes already exist in patients with pre-existing arrhythmias following cardiac surgery and may predispose this population to developing pre-eclampsia with severe features during their pregnancy.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Pregnancy Outcomes in Women with Arrhythmias following Surgical Repair of Cardiac Defects

et al. 2022

View full text Add to dashboard Cite

Objective: The goal of this study was to investigate whether pre-existing cardiac arrhythmias are associated with adverse obstetrical outcomes in women with a history of open cardiac surgery. Study Design: This was a retrospective cohort study of women with a history of open cardiac surgery who delivered at MedStar Washington Hospital Center (Washington, DC) from January 2007 through December 2018. Women with isolated percutaneous cardiac surgical repair were excluded. Maternal and neonatal outcomes were compared between patients with pre-existing cardiac arrhythmias and patients without pre-existing cardiac arrythmias. Maternal outcomes studied were intensive care unit (ICU) admission, postpartum blood loss greater than 1000 mL, congestive heart failure (CHF) development, pre-eclampsia with severe features, postpartum readmission, postpartum cardiac events, and postpartum length of stay >5 days. Neonatal outcomes investigated were low birth weight <2500g, Apgar scores <7 at 5 minutes, and neonatal intensive care unit (NICU) admission. Multivariate logistic regression model was used calculate adjusted odds ratio (aOR) and 95% confidence intervals (95% CI). Results: The outcomes for sixety-nine deliveries from fifty-six women with a history of open cardiac surgery were examined. Thirty-three women (48%) had arrhythmias after cardiac surgery with fourteen (20%) requiring Implantable Cardiac Defibrillators (ICDs). Two women (6%) with pre-existing arrhythmias after cardiac surgery developed postpartum volume overload requiring readmission (p=0.06). After controlling for age, gestational age at delivery and BMI, pre-eclampsia with severe features (p=0.02) and low birth weight neonates (p=0.02, aOR 2.26 (0.56-9.03)) remained statistically more like to occur in patients with pre-existing cardiac arrythmias than in patients without pre-existing arrhythmias. Conclusion: Women with a history of open cardiac surgery and pre-existing cardiac arrhythmias prior to pregnancy are more likely to develop pre-eclampsia with severe features and have low birth weight neonates compared to women with a history of open cardiac surgery without pre-existing cardiac arrhythmias.

show abstract

Impact of preeclampsia on ventricular repolarization indices

Cited by 8 publications

References 25 publications

Impacts of gene variants on drug effects-the foundation of genotype-guided pharmacologic therapy for long QT syndrome and short QT syndrome

Impacts of gene variants on drug effects-the foundation of genotype-guided pharmacologic therapy for long QT syndrome and short QT syndrome

Managing arrhythmia in cardiac resynchronisation therapy

Pregnancy Outcomes in Women with Arrhythmias following Surgical Repair of Cardiac Defects

Contact Info

Product

Resources

About