Impact of prenatal and postnatal nutritional manipulation on bone quality in adult Wistar rats offspring

Syggelos, Nikolaos; Augoulea, Areti; Armeni, Eleni; Kaparos, George; Vafaei, Homeira; Dontas, Ismene; Marinou, Kyriakoula; Vaggos, George; Raptou, P.; Lambrinoudaki, Ιrene; Eleftheriades, Makarios; Nicolaides, Kypros H.

doi:10.1016/j.nutos.2020.12.004

Cited by 3 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this sense, studies conducted in streptozotocin-induced diabetic adult rats, which are characterized by induced hyperglycemia, have observed that diabetic animals display lower BMD and connection density along with compromised bone microstructure compared to control healthy rats [ 14 ]. Similarly, another study evaluating the effects of prenatal and postnatal dietary manipulations on bone parameters of rats concluded that a perinatal high fat diet was associated with acquisition of suboptimal skeletal parameters which was mediated by elevated insulin levels [ 43 ]. In humans, nutritional restriction during the early stages of life followed by a period of catch-up growth during infancy promotes a higher insulin response relative to that of children with a normal growth pattern [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Complex and Slow Digestive Carbohydrates Promote Bone Mass and Improve Bone Microarchitecture during Catch-Up Growth in Rats

Bueno-Vargas¹,

Manzano²,

Pérez-Castillo³

et al. 2022

Nutrients

View full text Add to dashboard Cite

Catch-up growth is a process that promotes weight and height gains to recover normal growth patterns after a transient period of growth inhibition. Accelerated infant growth is associated with reduced bone mass and quality characterized by poor bone mineral density (BMD), content (BMC), and impaired microarchitecture. The present study evaluated the effects of a diet containing slow (SDC) or rapid (RDC) digestible carbohydrates on bone quality parameters during the catch-up growth period in a model of diet-induced stunted rats. The food restriction period negatively impacted BMD, BMC, and microarchitecture of appendicular and axial bones. The SDC diet was shown to improve BMD and BMC of appendicular and axial bones after a four-week refeeding period in comparison with the RDC diet. In the same line, the micro-CT analysis revealed that the trabecular microarchitecture of tibiae and vertebrae was positively impacted by the dietary intervention with SDC compared to RDC. Furthermore, features of the cortical microstructure of vertebra bones were also improved in the SDC group animals. Similarly, animals allocated to the SDC diet displayed modest improvements in growth plate thickness, surface, and volume compared to the RDC group. Diets containing the described SDC blend might contribute to an adequate bone formation during catch-up growth thus increasing peak bone mass, which could be linked to reduced fracture risk later in life in individuals undergoing transient undernutrition during early life.

show abstract

Section: Discussionmentioning

confidence: 99%

Dietary Complex and Slow Digestive Carbohydrates Promote Bone Mass and Improve Bone Microarchitecture during Catch-Up Growth in Rats

Bueno-Vargas¹,

Manzano²,

Pérez-Castillo³

et al. 2022

Nutrients

View full text Add to dashboard Cite

show abstract

“…All rats delivered spontaneously on the 21st gestational day and neonates were immediately weighted (Figure 1). Starved group's offspring were categorized according to their birth weight as FGR (birth weight < mean birth weight of control group's offspring − 2 × standard deviation) and non FGR (birth weight > mean birth weight of control group's offspring − 2 × standard deviation) as previously described (20)(21)(22)(23)(24). Immediately after delivery, offspring were separated from their mothers and weighted.…”

Section: Animal Modelmentioning

confidence: 99%

Liver Proteome Profile of Growth Restricted and Appropriately Grown Newborn Wistar Rats Associated With Maternal Undernutrition

et al. 2021

Self Cite

View full text Add to dashboard Cite

BackgroundFetal growth restriction (FGR) has been associated with adverse perinatal outcomes and epigenetic modifications that impact gene expression leading to permanent changes of fetal metabolic pathways and thereby influence development of disease in childhood and adult life. In this study, we investigated the result of maternal food restriction on liver protein expression in Wistar male newborn pups.Materials & MethodsTen (n = 10) timed pregnant Wistar rats on their 14th day of gestation were randomly assigned to either control (n = 4) or food restricted group (n = 6). The control group had ad libitum access to food. In the food restricted group, maternal diet was limited in a moderate fashion (50%) from day 15 of pregnancy until delivery. All rats delivered spontaneously on day 21 and newborn pups were immediately weighed. Pups born to normally nourished mothers were considered as controls, while pups born to food restricted mothers were subdivided into two groups, based on their birth weight: growth restricted (FGR) and appropriately grown (non-FGR). Rats were euthanized immediately after birth and liver tissues of 11 randomly selected male offspring (FGR n = 4, non-FGR n = 4, control n = 3) were collected and analyzed using quantitative proteomics.ResultsIn total 6,665 proteins were profiled. Of these, 451 and 751 were differentially expressed in FGR and non-FGR vs. control, respectively, whereas 229 proteins were commonly expressed. Bioinformatics analysis of the differentially expressed proteins (DEPs) in FGR vs. control revealed induction of the super-pathway of cholesterol biosynthesis and inhibition of thyroid hormone metabolism, fatty acid beta oxidation and apelin liver signaling pathway. Analysis of DEPs in non-FGR vs. control groups showed inhibition of thyroid hormone metabolism, fatty acid beta oxidation, and apelin liver signaling pathway.ConclusionThis study demonstrates the impact of prenatal food restriction on the proteomic liver profile of FGR and non-FGR offspring underlying the importance of both prenatal adversities and birth weight on liver-dependent postnatal disease.

show abstract

Effects of a high-fat diet on the bone structure of Wistar rats: a systematic review

et al. 2023

View full text Add to dashboard Cite

Context Saturated fats found in diets known as high-fat, cafeteria, or Western diets appear to have a negative effect on bone structure; however, few studies have focused on investigating this association, and the data available in the literature remain controversial. Objective The aim of the current review was to investigate the effects of a high-fat dietary intake on the bone structure of Wistar rats. Data Sources A search for articles was carried out in the Pubmed/MEDLINE, Web of Science, Embase, and Scopus databases. Data Extraction In total, 447 articles were found in the initial search; 5 articles were included in the systematic review, after application of the exclusion criteria. Data Analysis The review was guided by the PICOS strategy and based on the PRISMA protocol for animal reviews. Conclusion High-fat diets appear to affect bone structure of Wistar rats. Diet composition and exposure time are the factors determining the strength of the effect.

show abstract

Impact of prenatal and postnatal nutritional manipulation on bone quality in adult Wistar rats offspring

Cited by 3 publications

References 29 publications

Dietary Complex and Slow Digestive Carbohydrates Promote Bone Mass and Improve Bone Microarchitecture during Catch-Up Growth in Rats

Dietary Complex and Slow Digestive Carbohydrates Promote Bone Mass and Improve Bone Microarchitecture during Catch-Up Growth in Rats

Liver Proteome Profile of Growth Restricted and Appropriately Grown Newborn Wistar Rats Associated With Maternal Undernutrition

Effects of a high-fat diet on the bone structure of Wistar rats: a systematic review

Contact Info

Product

Resources

About