Impact of prenatal arsenic exposure on the testes and epididymides of prepubertal rats

Souza, Ana Cláudia Ferreira; Machado‐Neves, Mariana; Bastos, Daniel Silva Sena; Santos, Felipe Couto; Ervilha, Luiz Otávio Guimarães; Coimbra, John Lennon de Paiva; Araújo, Larissa de; Oliveira, Leandro Licursi de; Guimarães, Simone Eliza Facioni

doi:10.1016/j.cbi.2020.109314

Cited by 16 publications

(18 citation statements)

References 49 publications

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“…Chronic As trioxide exposure to parental male at a dose of 1 mg/L showed genotoxic damage in F0-F3, altered methylation patterns, changes in reproductive parameters, morphological damage in the ovaries (F0 and F1) and testicles (F1-F3), and compromised sperm quality (F0-F3, except F2) [138]. Exposure of sodium arsenite at the dose of 10 mg/L in drinking water to pregnant females from GD1-21 affected body weight and initial sexual development in male pups and relative anogenital distance also showed changes in the expression of SOD1, SOD2, CAT, and GSTK1 gene in male pup rat [139]. Administration of sodium arsenite at a concentration of 10 mg/L showed lower sperm production, sperm count, motility, and quality in the epididymis of rats [140].…”

Section: Pre-natal Arsenic Exposure Induced Male Reproductive Toxicit...mentioning

confidence: 99%

Contemporary Comprehensive Review on Arsenic-Induced Male Reproductive Toxicity and Mechanisms of Phytonutrient Intervention

Rachamalla

Chinthada

Kushwaha

et al. 2022

Toxics

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Arsenic (As) is a poisonous metalloid that is toxic to both humans and animals. Drinking water contamination has been linked to the development of cancer (skin, lung, urinary bladder, and liver), as well as other disorders such as diabetes and cardiovascular, gastrointestinal, neurological, and developmental damage. According to epidemiological studies, As contributes to male infertility, sexual dysfunction, poor sperm quality, and developmental consequences such as low birth weight, spontaneous abortion, and small for gestational age (SGA). Arsenic exposure negatively affected male reproductive systems by lowering testicular and accessory organ weights, and sperm counts, increasing sperm abnormalities and causing apoptotic cell death in Leydig and Sertoli cells, which resulted in decreased testosterone synthesis. Furthermore, during male reproductive toxicity, several molecular signalling pathways, such as apoptosis, inflammation, and autophagy are involved. Phytonutrient intervention in arsenic-induced male reproductive toxicity in various species has received a lot of attention over the years. The current review provides an in-depth summary of the available literature on arsenic-induced male toxicity, as well as therapeutic approaches and future directions.

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Section: Pre-natal Arsenic Exposure Induced Male Reproductive Toxicit...mentioning

confidence: 99%

Contemporary Comprehensive Review on Arsenic-Induced Male Reproductive Toxicity and Mechanisms of Phytonutrient Intervention

Rachamalla

Chinthada

Kushwaha

et al. 2022

Toxics

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show abstract

“…So, the pathology of metabolically active organs like renal and hepatic tissues is a good experimental tool to study arsenic toxicity. Furthermore, arsenic is also responsible for damaging the male reproductive function in rats and mice and, after that, causing reduced spermatogenesis, sperm counts and motility (Liu et al, 2021;Souza et al, 2021). It also inhibits testosterone release, the function of the testicular enzyme and atrophy of male genital organs.…”

Section: Small Animal Model Using Rodentsmentioning

confidence: 99%

Environmental toxicology of arsenic: current understanding of toxicity, detection, and remedial strategies

Kumari

Bharti

2022

Preprint

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Arsenic toxicity is an important worldwide health problem of humans and animals due to environmental and occupational exposure through arsenic polluted water, air, soil and food items. It has a multifaceted health impact on animals, human beings, and the environment. Therefore, various experimental and clinical studies were undertaken and had been undergoing to understand its pathogenesis, identify the key biomarkers, medical and economic impact on the affected populations, timely detection and amelioration. However, despite these long-investigated studies, no conclusive information is available for prevention and control of arsenic toxicity, mainly due to complex epidemiology, scattered approach, and repetitive work. Hence, there is a need for literature that exclusively brings information on epidemiology, pathogenesis, and ameliorative measures of arsenic toxicity, which can help researchers and policymakers for effective future planning research and community control programs. In the above view, this article presents an extensive review on the current understanding of arsenic toxicity, detection methodologies, epidemiology, and remedial measures for the benefits of researchers, academicians, and policy makers in controlling arsenic eco-toxicology and direction for direction futuristic research.

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“…It has been reported that sodium arsenite causes declined mRNA expression of epididymal SOD1, SOD2, CAT and GST, which undoubtedly impede epididymal redox status and leads to reproductive disorders (Figure 4). 93 A recent finding has further elucidated that arsenic enhances the NO2/NO3 levels in the epididymis and thereby promotes nitrosative stress. 94 Another study on arsenic exposed epididymis of post-natal rats (52 days age) has reported a significant up-regulation of SOD1, CAT and GSTK1 genes in response to combat with the arsenic-induced oxidative stress.…”

Section: Redox Balancementioning

confidence: 99%

“…87 Increase of MDA level and decrease of enzymatic CAT activity have also been observed also suggesting altered redox state. 87 Recently Souza ACF 93 has reported that arsenic exposure on post-natal rats of 14 and 28 days caused increased activity of CAT to neutralize arsenic induced reactive species but exhaustion occurred finally reducing the activity below normal level. Souza ACF 93 has also stated that arsenic induced reduction of epididymal GST activity in post-natal rats of 28 days validating the malfunction of antioxidant enzyme that act against arsenic mediated oxidative stress.…”

Section: Redox Balancementioning

confidence: 99%

Molecular perspective concerning fluoride and arsenic mediated disorders on epididymal maturation of spermatozoa: A concise review

2021

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Epididymis is a complex tubular structure of male reproductive system where spermatozoa undergo maturation and gain the fertilizing ability. Epididymal pseudostratified columnar epithelium with different cell types play imperative role by their secretory properties and enrich the luminal microenvironment necessary for achieving spermatozoal motility. During epididymal transit several secretory proteins like P26h, SPAG11, HSPD1 and many others are deposited on spermatozoal surface. At the same time spermatozoal proteins are also modified in this intraluminal milieu, which include cyritestin, fertilin, CE9 and others. Natural and anthropogenic activities disclose various environmental pollutants which affect different physiological systems of animals and human being. Likewise, reproductive system is also being affected. Fluoride causes structural alterations of caput and cauda segments of epididymis. Redox homeostasis and functional integrity are also altered due to diminished activities of SOD1, GR, Crisp2, Lrp2 and other important proteins. On the contrary arsenic affects mostly on cauda segment. Redox imbalance and functional amendment in epididymis have been observed with arsenic revelation as evidenced by altered genomic appearance of SOD, GST, catalase, Ddx3Y, VEGF and VEGFR2. This review is dealt with structure-function interplay in normal epididymal spermatozoal maturation along with subsequent complications developed under fluoride and arsenic toxicities.

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Impact of prenatal arsenic exposure on the testes and epididymides of prepubertal rats

Cited by 16 publications

References 49 publications

Contemporary Comprehensive Review on Arsenic-Induced Male Reproductive Toxicity and Mechanisms of Phytonutrient Intervention

Contemporary Comprehensive Review on Arsenic-Induced Male Reproductive Toxicity and Mechanisms of Phytonutrient Intervention

Environmental toxicology of arsenic: current understanding of toxicity, detection, and remedial strategies

Molecular perspective concerning fluoride and arsenic mediated disorders on epididymal maturation of spermatozoa: A concise review

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