Impact of prenatal diagnosis of transposition of the great arteries on postnatal outcome

Domínguez-Manzano, P; Herraı̀z, Ignacio; Mendoza, Alberto; Aguilar, José Manuel Ruano; Escribano, David; Toral, Belén; Gómez-Montes, Enery; Galindo, Alberto

doi:10.1080/14767058.2016.1265934

Cited by 11 publications

(8 citation statements)

References 25 publications

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“…The most common outflow tract anomalies, such as TOF, d‐TGA, DORV with pulmonary stenosis, or DORV with malposed great arteries, can cause significant cyanosis and hypoxia after birth leading to poor neonatal outcomes if not appropriately treated in a timely manner; the long‐term survival rates are high if appropriately treated. Prenatal detection with timely post‐delivery access to cardiac medical and surgical management improves mortality rates and outcomes …”

Section: Discussionmentioning

confidence: 99%

Prenatal detection of critical cardiac outflow tract anomalies remains suboptimal despite revised obstetrical imaging guidelines

Sun

Proudfoot

McCandless

2018

Congenital Heart Disease

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Section: Discussionmentioning

confidence: 99%

Prenatal detection of critical cardiac outflow tract anomalies remains suboptimal despite revised obstetrical imaging guidelines

Sun

Proudfoot

McCandless

2018

Congenital Heart Disease

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“… [3 , 9 , 10] Early administration of PGE1 (alprostadil) within the first 48 hours after birth has been found to reduce early mortality in newborns with TGA. [11] The patient needs to be commenced on PGE1 infusion at the rate of 0.05 - 0.1 μg/kg/min as soon as the diagnosis of d-TGA is confirmed. This will help to maintain ductal patency and promote left-to-right intracardiac mixing, and thereby increase the level of oxygenated blood reaching the left atrium.…”

Section: Discussionmentioning

confidence: 99%

Delayed presentation of transposition of the great arteries with intact ventricular septum in an 8-week-old male infant at University College Hospital in Ibadan, Nigeria

Labaeka

2021

S Afr J Crit Care

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Transposition of the great arteries is a rare type of critical congenital heart disease (CCHD) which commonly presents in the neonatal period and requires early diagnosis and intervention if the infant is to witness his/her first birthday. Here, we report a case of an 8-week-old term male infant who presented with a 2-day history of cough, breathlessness and cyanosis. Echocardiography confirmed dextro-transposition of the great arteries (d-TGA) with patent ductus arteriosus (PDA) and patent foramen ovale (PFO). The infant succumbed to cardiogenic shock due to late presentation and no access to definitive surgical intervention.

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“…Considering that congenital heart disease is the cause of 42% infant death, the importance of antenatal diagnosis is obvious (4). Antenatal diagnosis has prognostic importance on infant survival, especially in infants with hypoplastic left heart syndrome and transposition of great arteries (2,5).…”

Section: Discussionmentioning

confidence: 99%

Fetal Echocardiography Characteristics in a Tertiary Center

Erolu¹

2020

Erciyes Med J

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Objective: Fetal echocardiography is an important and growing diagnostic tool for early detection of congenital heart diseases and rhythm problems. In this study, we evaluated retrospectively indications and prenatal and postnatal diagnoses for fetal echocardiography. Materials and Methods: Prenatal and postnatal echocardiographic diagnoses of the newborns and data of pregnant women who were referred to the Pediatric Cardiology Clinic of Ümraniye Training and Research Hospital between October 2018 and October 2019 and newborns were obtained from medical recordings. Results: In this study, 138 patients were included. Eighty-one (58%) indication was suspected congenital heart disease, twenty-four indications (13%) was screening test positivity, 10 hyperechogenic focus, two advanced age pregnancy, six diabetes mellitus. Two were hydrops fetalis (immune/nonimmune), five dysrhythmias, one fetal anomaly. Hereditary causes were congenital heart disease in seven previous pregnancies. Sixty-eight patients with normal fetal echocardiography were normal in the postnatal period. Diagnosis of cyanotic congenital heart diseases was 24.2% of all patients, and 47.1% were acyanotic congenital heart disease in our study population. Four of the patients had arcus aorta anomalies. One patient had sustained supraventricular tachycardia with hydrops fetalis resolved with sotalol and digoxin treatment. One patient had neonatal thyrotoxicosis because of maternal graves disease Conclusion: Fetal echocardiography is a useful and noninvasive method for early diagnosis and treatment, especially in rhythm problems. Also, diagnosis of congenital heart diseases antenatally is useful for planning the management of the disease.

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Impact of prenatal diagnosis of transposition of the great arteries on postnatal outcome

Abstract: Adequate measures in the first 48 h after birth are essential to reduce the early mortality in TGA, especially in the simple form. This can be provided by prenatal diagnosis or by early neonatal clinical suspicion and prompt measures.

Cited by 11 publications

References 25 publications

Prenatal detection of critical cardiac outflow tract anomalies remains suboptimal despite revised obstetrical imaging guidelines

Prenatal detection of critical cardiac outflow tract anomalies remains suboptimal despite revised obstetrical imaging guidelines

Delayed presentation of transposition of the great arteries with intact ventricular septum in an 8-week-old male infant at University College Hospital in Ibadan, Nigeria

Fetal Echocardiography Characteristics in a Tertiary Center

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