Impact of Prenatal Disorders on the Metabolic Profile of Second Trimester Amniotic Fluid: A Nuclear Magnetic Resonance Metabonomic Study

Graça, Gonçalo; Duarte, Iola F.; Barros, António S.; Goodfellow, Brian J.; Diaz, Sílvia O.; Pinto, Joana; Carreira, Isabel M.; Galhano, Eulália; Pita, Cristina; Gil, Ana M.

doi:10.1021/pr100815q

Cited by 91 publications

(162 citation statements)

References 36 publications

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“…In addition, the GDM diagnostic criteria used varied among the studies. Two studies specified using O’Sullivan and Mahan criteria [19, 20], seven studies used Carpenter–Coustan criteria [21-27]; three studies referenced the World Health Organization [28-30], one study referenced the Fourth International Gestational Diabetes Workshop criteria, and four studies did not specify the GDM diagnostic criteria used [31-34]. …”

Section: Resultsmentioning

confidence: 99%

A systematic review of metabolite profiling in gestational diabetes mellitus

2014

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Aims/hypothesis Gestational diabetes mellitus is associated with adverse maternal and fetal outcomes during, as well as subsequent to, pregnancy, including increased risk of type 2 diabetes and cardiovascular disease. Because of the importance of early risk stratification in preventing these complications, improved first-trimester biomarker determination for diagnosing gestational diabetes would enhance our ability to optimise both maternal and fetal health. Metabolomic profiling, the systematic study of small molecule products of biochemical pathways, has shown promise in the identification of key metabolites associated with the pathogenesis of several metabolic diseases, including gestational diabetes. This article provides a systematic review of the current state of research on biomarkers and gestational diabetes and discusses the clinical relevance of metabolomics in the prediction, diagnosis and management of gestational diabetes. Methods We conducted a systematic search of MEDLINE (PubMed) up to the end of February 2014 using the key term combinations of 'metabolomics,' 'metabonomics,' 'nuclear magnetic spectroscopy,' 'mass spectrometry,' 'metabolic profiling' and 'amino acid profile' combined (AND) with 'gestational diabetes'. Additional articles were identified through searching the reference lists from included studies. Quality assessment of included articles was conducted through the use of QUADOMICS. Results This systematic review included 17 articles. The biomarkers most consistently associated with gestational diabetes were asymmetric dimethylarginine and NEFAs. After QUADOMICS analysis, 13 of the 17 included studies were classified as 'high quality'. Conclusions/interpretation Existing metabolomic studies of gestational diabetes present inconsistent findings regarding metabolite profile characteristics. Further studies are needed in larger, more racially/ethnically diverse populations.

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Section: Resultsmentioning

confidence: 99%

A systematic review of metabolite profiling in gestational diabetes mellitus

2014

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“…So far, no data has been published explicitly on eventual effects of fetal metabolites on the development of maternal GDM during pregnancy. However, first hints of an association of fetal metabolites and maternal GDM come from other metabolomics studies [53][54][55].…”

Section: Fetal Metabolites Associated With Maternal Gdmmentioning

confidence: 99%

Fetal Serum Metabolites Are Independently Associated with Gestational Diabetes Mellitus

Reichetzeder

Prehn

et al. 2018

Cell Physiol Biochem

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Background/Aims: Gestational diabetes (GDM) might be associated with alterations in the metabolomic profile of affected mothers and their offspring. Until now, there is a paucity of studies that investigated both, the maternal and the fetal serum metabolome in the setting of GDM. Mounting evidence suggests that the fetus is not just passively affected by gestational disease but might play an active role in it. Metabolomic studies performed in maternal blood and fetal cord blood could help to better discern distinct fetal from maternal disease interactions. Methods: At the time of birth, serum samples from mothers and newborns (cord blood samples) were collected and screened for 163 metabolites utilizing tandem mass spectrometry. The cohort consisted of 412 mother/child pairs, including 31 cases of maternal GDM. Results: An initial non-adjusted analysis showed that eight metabolites in the maternal blood and 54 metabolites in the cord blood were associated with GDM. After Benjamini-Hochberg (BH) procedure and adjustment for confounding factors for GDM, fetal phosphatidylcholine acyl-alkyl C 32:1 and proline still showed an independent association with GDM. Conclusions: This study found metabolites in cord blood which were associated with GDM, even after adjustment for established risk factors of GDM. To the best of our knowledge, this is the first study demonstrating an independent association between fetal

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“…In clinical practice, many studies have also focused on investigating amniotic fluid features, with metabolomics used for identifying markers of fetal malformations, prediagnostic gestational diabetes, and preterm delivery (30). Metabolic profiles of amniotic fluids collected during the second trimester of pregnancy were imprinted according to fetal malformations and gestational diabetes, per different energy, kidney, amino acid, and nucleotide metabolism.…”

Section: Metabolomics In Pediatric Researchmentioning

confidence: 99%

Metabolomics perspectives in pediatric research

et al. 2013

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Increasing evidence points toward the critical and long-term involvement of prenatal and early nutrition and lifestyle on later health and disease risk predisposition. Metabolomics is now a well-established top-down systems biology approach that explores the genetic-environment-health paradigm. The generalization of such approaches has opened new research areas to deepen our current understanding of many physiological processes, as well as foods and nutrient functionalities in target populations. It is envisioned that this will provide new avenues toward preventive medicine and prognostic strategies for tailored therapeutic and personalized nutrition management. The development of systems biology approaches and the new generation of biomarker patterns will provide the opportunity to associate complex metabolic regulations with the etiology of multifactorial pediatric diseases. This may subsequently lead to the development of system mechanistic hypotheses that could be targeted with new nutritional personalized concepts. Therefore, this review aims to describe recent applications of metabolomics in preclinical and clinical fields with insights into disease diagnostics/monitoring and improvement of homeostasis metabolic regulation that may be translatable to novel therapeutic and nutrition advances in pediatric research. Over the past decades, awareness about the role of nutrition and lifestyle in health and disease risk management has increased, with key emphasis on the prevention of metabolic disorders, including cardiometabolic diseases and type 2 diabetes (1-3). In parallel, increasing evidence points toward the critical and long-term involvement of early nutrition and lifestyle on later health and disease risk predisposition (4). It therefore becomes pertinent to look at newborn metabolism, development, and nutritional requirements to understand the onset of child and adult physiological conditions. Pregnancy, childbirth, lactation, and human milk composition are influenced by the intake of foods (macro-and micronutrients), which subsequently determine both the short-and long-term health and nutritional outcomes of an individual (5). Therefore, it is essential to build knowledge not only on the metabolic dysregulations but also on the effects of specific foods to comprehensively document the metabolic processes associated with individual health at the different stages of the life cycle (Figure 1). This will allow us to formulate nutritional solutions to improve or circumvent certain metabolic imbalances.The generalization of systems biology approaches has opened new research areas to further our current understanding of many physiological processes, as well as the functionalities of foods and nutrients. In particular, metabolomics is recognized as a powerful top-down systems biology approach to understand the genetic-environment-health paradigm and to identify clinically relevant biomarkers. Its application in clinical studies is envisioned to shed new light on the regulatory processes of complex mammalian sy...

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Impact of Prenatal Disorders on the Metabolic Profile of Second Trimester Amniotic Fluid: A Nuclear Magnetic Resonance Metabonomic Study

Cited by 91 publications

References 36 publications

A systematic review of metabolite profiling in gestational diabetes mellitus

A systematic review of metabolite profiling in gestational diabetes mellitus

Fetal Serum Metabolites Are Independently Associated with Gestational Diabetes Mellitus

Metabolomics perspectives in pediatric research

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