Impact of prenatal exposure to metallic elements on neural tube defects: Insights from human investigations

Huang, Wanqi; Fu, Jialin; Yuan, Zhengwei; Gu, Hui

doi:10.1016/j.ecoenv.2023.114815

Cited by 6 publications

(1 citation statement)

References 79 publications

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“…Concerning gestational complications, broadly, molybdenum status, as evaluated from maternal urine, serum, and plasma from existing second-and third-trimester studies, was not associated with preterm-birth, smallfor-gestational-age (SGA), or pre-eclampsia outcomes [137,146,[150][151][152]. A recent review by Huang and colleagues [153] reported significantly increased concentrations of molybdenum in maternal serum [154], maternal hair [155], umbilical cord tissue [156] and amniotic fluid [157] from healthy controls in comparison to pregnancies affected by neural tube defects (NTDs) (Table 4). Increased concentrations of molybdenum in maternal serum were associated with reduced risk of neural tube defects in the same study, with no correlation between molybdenum content and gestational age [154].…”

Section: Molybdenum and Foetal Developmentmentioning

confidence: 99%

Does the Micronutrient Molybdenum Have a Role in Gestational Complications and Placental Health?

et al. 2023

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Molybdenum is an essential trace element for human health and survival, with molybdenum-containing enzymes catalysing multiple reactions in the metabolism of purines, aldehydes, and sulfur-containing amino acids. Recommended daily intakes vary globally, with molybdenum primarily sourced through the diet, and supplementation is not common. Although the benefits of molybdenum as an anti-diabetic and antioxidant inducer have been reported in the literature, there are conflicting data on the benefits of molybdenum for chronic diseases. Overexposure and deficiency can result in adverse health outcomes and mortality, although physiological doses remain largely unexplored in relation to human health. The lack of knowledge surrounding molybdenum intake and the role it plays in physiology is compounded during pregnancy. As pregnancy progresses, micronutrient demand increases, and diet is an established factor in programming gestational outcomes and maternal health. This review summarises the current literature concerning varied recommendations on molybdenum intake, the role of molybdenum and molybdoenzymes in physiology, and the contribution these play in gestational outcomes.

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