Impact of Preoperative MRI in Invasive Ductal Carcinoma With Lobular Features on Core Biopsy

Jafferbhoy, Sadaf; Goussous, Ghaleb; Chandarana, Mihir; Salehi-Bird, Seema; Mohd-Isa, Zatinahhayu; Gunning, Elizabeth; Bajwa, Saba; Hammond, Lisette; Marla, Sekhar; Narayanan, Sankaran; Soumian, Soni

doi:10.1016/j.clbc.2020.08.007

Clinical Breast Cancer

2021

DOI: 10.1016/j.clbc.2020.08.007

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Impact of Preoperative MRI in Invasive Ductal Carcinoma With Lobular Features on Core Biopsy

Sadaf Jafferbhoy

Ghaleb Goussous

Mihir Chandarana

et al.

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2023

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Cited by 2 publications

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Clinicopathologic and genomic features of lobular like invasive mammary carcinoma: is it a distinct entity?

Silva

et al. 2023

npj Breast Cancer

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This study describes “lobular-like invasive mammary carcinomas” (LLIMCas), a group of low- to intermediate-grade invasive mammary carcinomas with discohesive, diffusely infiltrative cells showing retained circumferential membranous immunoreactivity for both E-cadherin and p120. We analyzed the clinical-pathologic features of 166 LLIMCas compared to 104 classical invasive lobular carcinomas (ILCs) and 100 grade 1 and 2 invasive ductal carcinomas (IDCs). Tumor size and pT stage of LLIMCas were intermediate between IDCs and ILCs, and yet often underestimated on imaging and showed frequent positive margins on the first resection. Despite histomorphologic similarities to classical ILC, the discohesion in LLIMCa was independent of E-cadherin/p120 immunophenotypic alteration. An exploratory, hypothesis-generating analysis of the genomic features of 14 randomly selected LLIMCas and classical ILCs (7 from each category) was performed utilizing an FDA-authorized targeted capture sequencing assay (MSK-IMPACT). None of the seven LLIMCas harbored CDH1 loss-of-function mutations, and none of the CDH1 alterations detected in two of the LLIMCas was pathogenic. In contrast, all seven ILCs harbored CDH1 loss-of-function mutations coupled with the loss of heterozygosity of the CDH1 wild-type allele. Four of the six evaluable LLIMCas were positive for CDH1 promoter methylation, which may partially explain the single-cell infiltrative morphology seen in LLIMCa. Further studies are warranted to better define the molecular basis of the discohesive cellular morphology in LLIMCa. Until more data becomes available, identifying LLIMCas and distinguishing them from typical IDCs and ILCs would be justified. In patients with LLIMCas, preoperative MRI should be entertained to guide surgical management.

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Clinicopathologic and genomic features of lobular like invasive mammary carcinoma: is it a distinct entity?

Silva

et al. 2023

npj Breast Cancer

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Preoperative Breast MRI: Current Evidence and Patient Selection

Christensen

Shehata

Javid

et al. 2023

Journal of Breast Imaging

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Breast MRI is the most sensitive imaging modality for the assessment of newly diagnosed breast cancer extent and can detect additional mammographically and clinically occult breast cancers in the ipsilateral and contralateral breasts. Nonetheless, appropriate use of breast MRI in the setting of newly diagnosed breast cancer remains debated. Though highly sensitive, MRI is less specific and may result in false positives and overestimation of disease when MRI findings are not biopsied prior to surgical excision. Furthermore, improved anatomic depiction of breast cancer on MRI has not consistently translated to improved clinical outcomes, such as lower rates of re-excision or breast cancer recurrence, though there is a paucity of well-designed studies examining these issues. In addition, current treatment paradigms have been developed in the absence of this more accurate depiction of disease span, which likely has limited the value of MRI. These issues have led to inconsistent and variable utilization of preoperative MRI across practice settings and providers. In this review, we discuss the history of breast MRI and its current use and recommendations with a focus on the preoperative setting. We review the evidence surrounding the use of preoperative MRI in the evaluation of breast malignancies and discuss the data on breast MRI in the setting of specific patient factors often used to determine breast MRI eligibility, such as age, index tumor phenotype, and breast density. Finally, we review the impact of breast MRI on surgical outcomes (re-excision and mastectomy rates) and long-term breast recurrence and survival outcomes.

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Impact of Preoperative MRI in Invasive Ductal Carcinoma With Lobular Features on Core Biopsy

Cited by 2 publications

References 22 publications

Clinicopathologic and genomic features of lobular like invasive mammary carcinoma: is it a distinct entity?

Clinicopathologic and genomic features of lobular like invasive mammary carcinoma: is it a distinct entity?

Preoperative Breast MRI: Current Evidence and Patient Selection

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