“…Scarring of connective tissue and vessels might influence and reduce blood flow, but clinical studies suggest that radiotherapy does not have any obvious effect on the viability of microvascular flap reconstruction (Chao et al, 2012;Hohlweg-Majert et al, 2012;le Nobel et al, 2012;Benatar et al, 2013). Controversy remains as to the effect of radiotherapy on the rate and severity of local surgical bed complications after free tissue transfer (Choi et al, 2004;Geretschlager et al, 2012;le Nobel et al, 2012).…”