Impact of Preoperative Visceral Fat Area Measured by Bioelectrical Impedance Analysis on Clinical and Oncologic Outcomes of Colorectal Cancer

Abstract

Background: Some studies have shown that an increase in visceral fat is associated with postoperative clinical and oncologic outcomes. However, no studies have used bioelectrical impedance analysis (BIA) to determine the effects of visceral fat on the oncologic outcomes of colorectal cancer (CRC). This study aimed to investigate the impact of preoperative visceral fat area measured by bioelectrical impedance analysis on clinical and oncologic outcomes of colorectal cancer Methods: This study included 203 patients who underwent anthropometric measurements by BIA before surgical treatment for CRC between January 2016 and June 2020. Results: According to the cut-off level of VFA by receiver operating characteristic curve analysis, 85 (40.5%) patients had a low VFA, and 119 (59.5%) had a high VFA. Multivariate analysis found that preoperative CRP (hazard ratio (HR), 3.882; 95% confidence interval (CI), 1.001–15.051; p = 0.050) and nodal stage (HR, 7.996; 95% CI, 1.414–45.209; p = 0.019) were independent prognostic factors for overall survival, while sex (HR, 0.110; 95% CI, 0.013–0.905; p = 0.040), lymphovascular invasion (HR, 3.560; 95% CI, 1.098–11.544; p = 0.034), and VFA (HR, 4.263; 95% CI, 1.280–14.196; p = 0.040) were independent prognostic factors for disease-free survival (DFS). Conclusions: Preoperative VFA measured by BIA had no significant impact on postoperative clinical outcomes and was an independent prognostic factor for disease-free survival.

Influence of body composition assessment with bioelectrical impedance vector analysis in cancer patients undergoing surgery

“…The utilization of bioelectrical impedance analysis (BIA) for measuring body composition has generated significant interest in using various indicators, including skeletal muscle index (SMI), phase angle (PA), fat mass (FM), fat-free mass (FFM), fat-free mass index (FFMI), cellular water, to predict outcomes in patients with lung cancer ( 3 , 4 ), breast cancer ( 5 ), prostate cancer ( 6 ), gastric cancer ( 7 ) and colorectal cancer ( 8 ). In contrast to traditional BIA methods, bioelectrical impedance vector analysis BIVA can provide more objective information about hy and BCM ( 9 ).…”

Effect of preoperative pan-immune-inflammation value on clinical and oncologic outcomes after colorectal cancer surgery: a retrospective study

“…Song et al [ 30 ] reported that body composition indices, including fat and muscle indices, were related to platelet and lymphocyte ratios in CRC, particularly in male patients. Previous research has indicated that preoperative VFA measured using the BIA could serve as an independent prognostic factor for DFS [ 15 31 ]. However, in our study, no significant associations were observed between sarcopenia, VFA, phase angle, and PIV.…”

“…Bioelectrical impedance analysis (BIA) is a well-known noninvasive anthropometric measurement including body composition, fat index, muscle index, obesity index, and phase angle [ 15 ]. And skeletal muscle index (SMI) was calculated to diagnose sarcopenia [ 16 ].…”

Effect of body fat mass loss on prognosis of radical resection for pancreatic ductal adenocarcinoma based on bioelectrical impedance analysis

“…Several reports have evaluated postoperative changes in body composition using BIA and analyzed the risk factors for postoperative complications in patients with gastric cancer [21][22][23]. Moreover, in patients with colorectal cancer, a preoperative low SMI based on the BIA method was considered a risk factor for postoperative ileus [24], and preoperative visceral fat area measured by BIA was an independent prognostic factor for disease-free survival [25]. Only a few studies have investigated the relationship between the prognosis after radical resection of PDAC and body composition changes assessed by BIA.…”