Impact of pressure management during hypothermic selective cerebral perfusion on cerebral hemodynamics and metabolism in pigs

Haldenwang, PL; Strauch, J; Müllem, Katharina; Liakopoulos, OJ; Reiter, Harvard; Lehmacher, Walter; Wahlers, T

doi:10.1055/s-0029-1191673

Cited by 3 publications

(2 citation statements)

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“…5,6 In addition, several recent experimental reports provided evidence that cold cerebral perfusion can actually lead to neurologic injury because it, among other causes, negatively interferes with cerebral autoregulation. 16,17 MSH preserves cerebral autoregulation and favors equal distribution of perfusion in the brain. 18 The alpha-stat strategy for acid-base management on CPB just adds to it.…”

Section: Discussionmentioning

confidence: 99%

The impact of unilateral versus bilateral antegrade cerebral perfusion on surgical outcomes after aortic arch replacement: A propensity-matched analysis

Zierer

Risteski

Ahmad

et al. 2014

The Journal of Thoracic and Cardiovascular Surgery

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Using unilateral antegrade cerebral perfusion in a pressure-controlled manner during mild systemic hypothermia is a safe protection strategy in elective aortic arch surgery, associated with similar morbidity and mortality in comparison with bilateral antegrade cerebral perfusion, even if total arch replacement is required. Bilateral antegrade cerebral perfusion reveals a trend of higher incidence of stroke, probably due to manipulation on the arch vessels.

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Section: Discussionmentioning

confidence: 99%

The impact of unilateral versus bilateral antegrade cerebral perfusion on surgical outcomes after aortic arch replacement: A propensity-matched analysis

Zierer

Risteski

Ahmad

et al. 2014

The Journal of Thoracic and Cardiovascular Surgery

View full text Add to dashboard Cite

show abstract

“…These results can indicate that the cold cerebral perfusion can impair the regional cerebral flow due to the loss of vascular autoregulation. In experimental settings, such a situation could already be demonstrated [22]. A long duration of cold perfusion or unbalanced perfusion due to vascular pathology, for example, cerebrovascular microangiopathy, can therefore be considered as a cause of neurological damage during cerebral perfusion.…”

Section: Discussionmentioning

confidence: 99%