Objective: To describe the association between malocclusion and oral health-related quality of life (SOQL) in children aged 3-5 years in Salvador-BA.Methods: This is a cross-sectional study involving children from health units and/or enrolled in public day care centers in 2018. The inclusion criteria were to be between 3 and 5 years old, be enrolled in municipal day care centers and be present during the gathering.Exclusion criteria: Age outside the 3-5 years age group; not offering assent; have health conditions that make the exam unfeasible; not having the free and informed consent term and the questionnaire signed by the parents/guardians.Results: 1566 children aged 3-5 years participated. The mean age was 53.5 months. 50.4% belong to the male gender, most were declared to be brown (60.7%) and black (31.7%). Malocclusion was moderate/severe in 26% of the population and the most frequent was anterior open bite (13.9%). There was a statistically significant difference between malocclusion and B-ECOHIS for pain in the teeth, mouth or jaws (p-value=0.05), difficulty in drinking (p-value=0.02), eating (p-value=0.02)-value=0.02), and difficulty sleeping (p-value=0.04).Conclusion: Malocclusion has a potential association with conditions that interfere with the reduction of OHRQL in children aged 3-5 years.