Impact of prior cancer history on the survival of patients with larynx cancer

Zhu, Kaiquan; Lin, Rongcheng; Zhang, Ziheng; Chen, Huanqi; Rao, Xingwang

doi:10.1186/s12885-020-07634-2

Cited by 18 publications

(21 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In consequence, the detrimental effect of secondary PCa appears robust and generalizable. The observation of Zhu et al validates our hypothesis about the aggressiveness of primary cancer that may impact, as well as determine the natural history of treated secondary malignancies (24). The above findings, especially that with longer time interval between primary cancer and secondary PCa life expectancy approximates the life expectancy to primary PCa, should be considered treatment decision making, when secondary PCa patients are counseled.…”

Section: Discussionsupporting

confidence: 69%

“…Second, the nature of our data does not allow to define specific mortality time points to estimate Kaplan-Meier actuarial mortality rates. This limitation is shared with all previous publications focusing on secondary cancers, after specific primary cancers in large-scale databases (24)(25)(26). Limited stage and grade information was available for each of the 10 examined primary cancers and matching could not be performed for PSA and Gleason grade group without losing secondary PCa patients.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of 10 Most Common Nonurological Primary Cancers on Survival in Men With Secondary Prostate Cancer

et al. 2021

View full text Add to dashboard Cite

BackgroundThis study aims to test the effect of the 10 most common nonurological primary cancers (skin, rectal, colon, lymphoma, leukemia, pancreas, stomach, esophagus, liver, lung) on overall mortality (OM) after secondary prostate cancer (PCa).Material and MethodsWithin the Surveillance, Epidemiology, and End Results (SEER) database, patients with 10 most common primary cancers and concomitant secondary PCa (diagnosed 2004–2016) were identified and were matched in 1:4 fashion (age, year at diagnosis, race/ethnicity, treatment type, TNM stage) with primary PCa controls. OM was compared between secondary and primary PCa patients and was stratified according to primary cancer type, as well as according to time interval between primary cancer vs. secondary PCa diagnoses.ResultsWe identified 24,848 secondary PCa patients (skin, n = 3,871; rectal, n = 798; colon, n = 3,665; lymphoma, n = 2,583; leukemia, n = 1,102; pancreatic, n = 118; stomach, n = 361; esophagus, n = 219; liver, n = 160; lung, n = 1,328) vs. 531,732 primary PCa patients. Secondary PCa characteristics were less favorable than those of primary PCa patients (PSA and grade), and smaller proportions of secondary PCa patients received active treatment. After 1:4 matching, all secondary PCa exhibited worse OM than primary PCa patients. Finally, subgroup analyses showed that the survival disadvantage of secondary PCa patients decreased with longer time interval since primary cancer diagnosis and subsequent secondary PCa.ConclusionPatients with secondary PCa are diagnosed with less favorable PSA and grade. Even after matching for PCa characteristics, secondary PCa patients still exhibit worse survival. However, the survival disadvantage is attenuated, when secondary PCa diagnosis is made after longer time interval, since primary cancer diagnosis.

show abstract

Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

The Effect of 10 Most Common Nonurological Primary Cancers on Survival in Men With Secondary Prostate Cancer

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Hence, we guessed that there was no enrichment for a cancer type that may increase the risk of developing EC as an SPM. Similarly, Zhu et al [ 20 ] reported that the most common types of prior cancers in larynx cancer patients were from prostate, lung and bronchus, urinary bladder, and breast. Laccetti et al [ 21 ] found that prostate, gastrointestinal, breast, and other genitourinary were the most common types of prior cancer in locally advanced lung cancer.…”

Section: Discussionmentioning

confidence: 94%

Survival outcomes in esophageal cancer patients with a prior cancer

Pan

Gao

et al. 2021

Medicine

View full text Add to dashboard Cite

To achieve a deeper understanding of patients who developed esophageal cancer (EC) as a second primary malignancy, which may help guide in clinical practice for these patients in the future. In the primary cohort, EC patients with a prior malignancy were identified from the surveillance, epidemiology, and end result 18 database. The 5 most common types of prior cancers were picked out based on the frequency of occurrence. In addition, Kaplan–Meier and log-rank tests were performed to investigate the survival impacts of prior cancers on EC patients. Besides, a competing-risk model was constructed to explore the relationship between EC-treatment and EC-specific mortality. In the secondary cohort, patients with stage I–III (N0M0) EC from 2004 to 2014 were enrolled. After propensity score matching, univariate and multivariate Cox analyses were developed to determine the prognostic factors for EC patients. A total of 1199 EC patients with a prior cancer were identified in the primary cohort. The 5 most common sites of prior cancers were prostate, female breast, bladder, lung and bronchus, and larynx. Kaplan–Meier analyses revealed that EC patients with prior prostate cancer and bladder cancer had the best overall survival (OS), while those with prior cancers of larynx and lung and bronchus had the worst OS. Fine and Gray competing risks analysis indicated that the administration of surgery was closely associated with better EC-specific survival (P < .001). In the secondary cohort, multivariate Cox analyses found that age at diagnosis, race, tumor grade, tumor extent, nodal status and metastasis stage, histology, and the administration of surgery were prognostic factors for OS and cancer-specific survival in EC patients. Besides, the existence of a prior cancer was an independent prognostic factor for cancer-specific survival. EC remains to be the most important cause of death in EC patients with a prior cancer. EC related treatment should be actively adopted in patients with a prior cancer, as they were more likely to die from EC than the prior cancer. EC patients with a prior cancer had comparable OS than those without.

show abstract

“…Instead, only OM was available. This limitation is shared with all previous publications focusing on secondary cancers after specific primary cancers in large‐scale databases 30–32 . Limited stage and grade information was available for each of the six examined primary cancer.…”

Section: Discussionmentioning

confidence: 99%

The effect of primary urological cancers on survival in men with secondary prostate cancer

et al. 2021

View full text Add to dashboard Cite

Background To test the effect of urological primary cancers (bladder, kidney, testis, upper tract, penile, urethral) on overall mortality (OM) after secondary prostate cancer (PCa). Methods Within the Surveillance, Epidemiology and End Results (SEER) database, patients with urological primary cancers and concomitant secondary PCa (diagnosed 2004‐2016) were identified and were matched in 1:4 fashion with primary PCa controls. OM was compared between secondary and primary PCa patients and stratified according to primary urological cancer type, as well as to time interval between primary urological cancer versus secondary PCa diagnoses. Results We identified 5,987 patients with primary urological and secondary PCa (bladder, n = 3,287; kidney, n = 2,127; testis, n = 391; upper tract, n = 125; penile, n = 47; urethral, n = 10) versus 531,732 primary PCa patients. Except for small proportions of Gleason grade group and age at diagnosis, PCa characteristics between secondary and primary PCa were comparable. Conversely, proportions of secondary PCa patients which received radical prostatectomy were smaller (29.0 vs. 33.5%), while no local treatment rates were higher (34.2 vs. 26.3%). After 1:4 matching, secondary PCa patients exhibited worse OM than primary PCa patients, except for primary testis cancer. Here, no OM differences were recorded. Finally, subgroup analyses showed that the survival disadvantage of secondary PCa patients decreased with longer time interval since primary cancer diagnosis. Conclusions After detailed matching for PCa characteristics, secondary PCa patients exhibit worse survival, except for testis cancer patients. The survival disadvantage is attenuated, when secondary PCa diagnosis is made after longer time interval, since primary urological cancer diagnosis.

show abstract

Impact of prior cancer history on the survival of patients with larynx cancer

Cited by 18 publications

References 31 publications

The Effect of 10 Most Common Nonurological Primary Cancers on Survival in Men With Secondary Prostate Cancer

The Effect of 10 Most Common Nonurological Primary Cancers on Survival in Men With Secondary Prostate Cancer

Survival outcomes in esophageal cancer patients with a prior cancer

The effect of primary urological cancers on survival in men with secondary prostate cancer

Contact Info

Product

Resources

About