Impact of probiotics during weaning on the metabolic and inflammatory profile: follow-up at school age

Videhult, Frida Karlsson; Andersson, Yvonne; Öhlund, Inger; Stenlund, Hans; Hernell, Olle; West, Christina

doi:10.3109/09637486.2015.1025717

Cited by 13 publications

(8 citation statements)

References 41 publications

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“…A small number of studies assessing the long-term effect of probiotic supplementation on the prevention of overweight and obesity have been conducted. Karlsson et al [ 80 , 81 ] evaluated the effect of supplementation of porridge containing L. paracasei (

CFU per day for six months) strain in four-month-old infants. BMI, body mass, metabolic, and inflammatory markers did not differ between the control group and the probiotic group in children aged eight to nine years.…”

Section: Review Of Clinical Studies Using Probiotics In Obesitymentioning

confidence: 99%

Probiotics for the Treatment of Overweight and Obesity in Humans—A Review of Clinical Trials

et al. 2020

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The World Health Organization (WHO) reports that 400 million people are obese, and over 1.6 billion adults are overweight worldwide. Annually, over 2.8 million people die from obesity-related diseases. The incidence of overweight and obesity is steadily increasing, and this phenomenon is referred to as a 21st-century pandemic. The main reason for this phenomenon is an easy access to high-energy, processed foods, and a low-activity lifestyle. These changes lead to an energy imbalance and, as a consequence, to the development of body fat. Weight gain contributes to the development of heart diseases, skeletal system disorders, metabolic disorders such as diabetes, and certain types of cancer. In recent years, there have been many works linking obesity with intestinal microbiota. Experiments on germ-free animals (GFs) have provided much evidence for the contribution of bacteria to obesity. The composition of the gut microbiota (GM) changes in obese people. These changes affect the degree of energy obtained from food, the composition and secretory functions of adipose tissue, carbohydrate, and lipid metabolism in the liver, and the activity of centers in the brain. The study aimed to present the current state of knowledge about the role of intestinal microbiota in the development of obesity and the impact of supplementation with probiotic bacteria on the health of overweight and obese patients.

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Section: Review Of Clinical Studies Using Probiotics In Obesitymentioning

confidence: 99%

Probiotics for the Treatment of Overweight and Obesity in Humans—A Review of Clinical Trials

et al. 2020

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“…Significant down-regulation of HFD-induced expression of PPARy, FAS and TNS-α in adipose tissues.[58] Lactobacillus paracasei ssp. paracasei F19Increased plasma C-peptide, plasminogen activator inhibitor-1, leptin and serum high-sensitivity C-reactive protein (hsCRP) after overnight fasting in overweight/obese children.[59] Lactobacillus acidophilus La-5 and Bifidobacterium animalis subsp lactis BB-12After 6 weeks, there was a significant decrease in fructosamine levels (−9.91 mmol/L; p = 0.04) and hemoglobin A 1 c tended to be lower (−0.67%; p = 0.06) in probiotic group. TNF-α and resistin were significantly reduced in probiotic and control groups (−1.5 and −1.3 pg/mL, −.1 and −2.8 ng/mL, respectively).…”

Section: Probiotic Lab and Type-2 Diabetes Treatmentmentioning

confidence: 99%

Some current applications, limitations and future perspectives of lactic acid bacteria as probiotics

Evivie

Gui-cheng

Igene

et al. 2017

Food & Nutrition Research

151

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Several mechanism and non-mechanism-based studies supporting the claim that lactic acid bacteria (LAB) strains confer health benefits and play immune-modulatory roles were examined in this review. Probiotic applications of LAB on global burdens such as obesity and type-2 diabetes were discussed as well as the use of yoghurt and ice cream as important vehicles to convey several beneficial LAB strains. Probiotic and symbiotic dairy products may be used in the nearest future to treat a variety of health disorders. Current studies suggest that lactic acid bacteria possess anti-obesity and anti-diabetic propensities on their hosts and thus can play a crucial role in human health care. Research in the rheological and physicochemical properties of ice cream as well as its applications are also on the increase. These applications face certain hurdles including technological (for less developed countries), consumer acceptability of new functional foods may be influenced by culture, ethics or religion. There is need for more studies on the genetic basis for probiotic properties which will give further understanding regarding novel manipulation skills and applicability in nutrition and health sectors. More studies confirming the direct effects of probiotic LABs in lowering the spread of food-borne and other pathogens are also anticipated.

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“…Six studies (n = 1552 children; range in sample sizes: 38-600) evaluated the effect of pre-, pro-and synbiotics on biomarkers of systemic inflammation in healthy children (Table 2). Three studies recruited neonates [18][19][20] and three older children [21][22][23]. One study evaluated a prebiotic [18], four a single probiotic [19][20][21][22], of which two studies evaluated L. paracasei subsp.…”

Section: Health Status and Pre- Pro- And Synbiotic Interventionsmentioning

confidence: 99%

“…Three studies recruited neonates [18][19][20] and three older children [21][22][23]. One study evaluated a prebiotic [18], four a single probiotic [19][20][21][22], of which two studies evaluated L. paracasei subsp. paracasei F19 in the same daily dosage [20,22] and one synbiotic [19].…”

Section: Health Status and Pre- Pro- And Synbiotic Interventionsmentioning

confidence: 99%

Effect of Pre-, Pro-, and Synbiotics on Biomarkers of Systemic Inflammation in Children: A Scoping Review

Kadia,

Allen

2024

Nutrients

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Systemic inflammation plays a central role in many diseases and is, therefore, an important therapeutic target. In a scoping review, we assessed the evidence base for the anti-inflammatory effects of pre-, pro-, and synbiotics in children. Of the 1254 clinical trials published in English in Ovid Medline and Cochrane Library PubMed from January 2003 to September 2022, 29 were included in the review. In six studies of healthy children (n = 1552), one reported that fructo-oligosaccharides added to infant formula significantly reduced pro-inflammatory biomarkers, and one study of a single-strain probiotic reported both anti- and pro-inflammatory effects. No effects were seen in the remaining two single-strain studies, one multi-strain probiotic, and one synbiotic study. In 23 studies of children with diseases (n = 1550), prebiotics were tested in 3, single-strain in 16, multi-strain probiotics in 6, and synbiotics in 2 studies. Significantly reduced inflammatory biomarkers were reported in 7/10 studies of atopic/allergic conditions, 3/5 studies of autoimmune diseases, 1/2 studies of preterm infants, 1 study of overweight/obesity, 2/2 studies of severe illness, and 2/3 studies of other diseases. However, only one or two of several biomarkers were often improved; increased pro-inflammatory biomarkers occurred in five of these studies, and a probiotic increased inflammatory biomarkers in a study of newborns with congenital heart disease. The evidence base for the effects of pre-, pro-, and synbiotics on systemic inflammation in children is weak. Further research is needed to determine if anti-inflammatory effects depend on the specific pre-, pro-, and synbiotic preparations, health status, and biomarkers studied.

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Impact of probiotics during weaning on the metabolic and inflammatory profile: follow-up at school age

Cited by 13 publications

References 41 publications

Probiotics for the Treatment of Overweight and Obesity in Humans—A Review of Clinical Trials

Probiotics for the Treatment of Overweight and Obesity in Humans—A Review of Clinical Trials

Some current applications, limitations and future perspectives of lactic acid bacteria as probiotics

Effect of Pre-, Pro-, and Synbiotics on Biomarkers of Systemic Inflammation in Children: A Scoping Review

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