Impact of prolonged utilization of neprilysin inhibition on the cognitive function of heart failure patients

Shah, Niel; Dogar, Muhammad; Shah, Parin; Ishtiaq, Sameera; Mathew, Shawn; Shah, Pratik; Ishtiaq, Alia; Vittorio, Timothy J.

doi:10.1177/1753944718756563

Cited by 2 publications

(2 citation statements)

References 34 publications

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“…Analysis of the predicted complexes show that despite the searching area was centered on the close allosteric site B, which is comprised by residues Arg 24, Arg 254, Glu 262, Tyr 46, Asp 48, Val 49, Ile 219, and Met 258 [218], both sterols and triterpenes can interact with this site but also with the catalytic site, particularly with two of the most critical residues Cys 215 and Arg 221. This finding could explain the non-competitive and mixed-inhibition properties of some compounds, which has been experimentally demonstrated [212,219]. For example, fucosterol and β-sitosterol mainly occupy allosteric site B, while 6-hydroxy substituted sterols bind to both the catalytic site (via the 3β-OH group, the 6α-OH interacts through a hydrogen bond to Tyr 46 and Lys 120) and the allosteric site (Figure 2a).…”

Section: Antidiabetic and Metabolic Activitiesmentioning

confidence: 69%

Chemistry, Biological Activities and In Silico Bioprospection of Sterols and Triterpenes from Mexican Columnar Cactaceae

2020

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The Cactaceae family is an important source of triterpenes and sterols. The wide uses of those plants include food, gathering, medicinal, and live fences. Several studies have led to the isolation and characterization of many bioactive compounds. This review is focused on the chemistry and biological properties of sterols and triterpenes isolated mainly from some species with columnar and arborescent growth forms of Mexican Cactaceae. Regarding the biological properties of those compounds, apart from a few cases, their molecular mechanisms displayed are not still fully understand. To contribute to the above, computational chemistry tools have given a boost to traditional methods used in natural products research, allowing a more comprehensive exploration of chemistry and biological activities of isolated compounds and extracts. From this information an in silico bioprospection was carried out. The results suggest that sterols and triterpenoids present in Cactaceae have interesting substitution patterns that allow them to interact with some bio targets related to inflammation, metabolic diseases, and neurodegenerative processes. Thus, they should be considered as attractive leads for the development of drugs for the management of chronic degenerative diseases.

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Section: Antidiabetic and Metabolic Activitiesmentioning

confidence: 69%

Chemistry, Biological Activities and In Silico Bioprospection of Sterols and Triterpenes from Mexican Columnar Cactaceae

2020

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“…Triterpenoid saponins are secondary metabolites synthesized in plant and mammalian cells. Several studies have reported on the role of triperpenoid saponins as natural defence compounds in plants [2][3][4][5], and some members of triterpenoid saponins have also been found to possess beneficial pharmacological properties [6][7][8]. The literature contains structures of several hundred saponins isolated from various sources including plants and animals.…”

Section: Introductionmentioning

confidence: 99%

Screening for Triterpenoid Saponins in Plants Using Hyphenated Analytical Platforms

Khakimov

Tseng

Godeljohann

et al. 2016

Preprint

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Abstract:Recently the number of studies investigating triterpenoid saponins has drastically increased due to their diverse and potentially attractive biological activities. Currently the literature contains chemical structures of few hundreds of triterpenoid saponins of plant and animal origin. Triterpenoid saponins consist of a triterpene aglycone with one or more sugar moieties attached to it. However, due to similar physico-chemical properties, isolation and identification of a large diversity of triterpenoid saponins remain challenging. This study demonstrates a methodology to screen saponins using hyphenated analytical platforms, GC-MS, LC-MS/MS, and LC-SPE-NMR/MS, in the example of two different phenotypes of the model plant Barbarea vulgaris (winter cress), glabrous (G) and pubescent (P) type that are known to differ by their insect resistance. The proposed methodology allows for detailed comparison of saponin profiles from intact plant extracts as well as saponin aglycone profiles from hydrolysed samples. Continuously measured 1D proton NMR data during LC separation along with mass spectrometry data revealed significant differences, including contents of saponins, types of aglycones and numbers of sugar moieties attached to the aglycone. A total of 49 peaks were tentatively identified as saponins from both plants; they are derived from eight types of aglycones and with 2-5 sugar moieties. Identification of two previously known insect-deterrent saponins, hederagenin cellobioside and oleanolic acid cellobioside, demonstrated the applicability of the methodology for relatively rapid screening of bioactive compounds.

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Impact of prolonged utilization of neprilysin inhibition on the cognitive function of heart failure patients

Cited by 2 publications

References 34 publications

Chemistry, Biological Activities and In Silico Bioprospection of Sterols and Triterpenes from Mexican Columnar Cactaceae

Chemistry, Biological Activities and In Silico Bioprospection of Sterols and Triterpenes from Mexican Columnar Cactaceae

Screening for Triterpenoid Saponins in Plants Using Hyphenated Analytical Platforms

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