Impact of Protein and Lipid on Neutralization Times of Hydrogen Peroxide Care Regimens

Ngo, William; Heynen, Miriam; Joyce, EM; Jones, Lyndon

doi:10.1097/icl.0b013e3181b93bd1

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…Hydrogen peroxide provides its antimicrobial activity by destabilising organic material through oxidation to damage cell membranes and components [167,184]. Lens cases usually include a catalyst, such as a platinum coated disc for neutralisation of the solution once it has been poured into the case, taking approximately six hours to fully neutralise, although the majority of anti-microbial activity and neutralisation occurs within the first 40 min [185].…”

Section: Oxidative Systemsmentioning

confidence: 99%

BCLA CLEAR - Orthokeratology

Vincent

Cho

Chan³

et al. 2021

Contact Lens and Anterior Eye

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115

103

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Orthokeratology (ortho-k) is the process of deliberately reshaping the anterior cornea by utilising specialty contact lenses to temporarily and reversibly reduce refractive error after lens removal. Modern ortho-k utilises reverse geometry lens designs, made with highly oxygen permeable rigid materials, worn overnight to reshape the anterior cornea and provide temporary correction of refractive error. More recently, ortho-k has been extensively used to slow the progression of myopia in children.This report reviews the practice of ortho-k, including its history, mechanisms of refractive and ocular changes, current use in the correction of myopia, astigmatism, hyperopia, and presbyopia, and standard of care. Suitable candidates for ortho-k are described, along with the fitting process, factors impacting success, and the potential options for using newer lens designs. Ocular changes associated with ortho-k, such as alterations in corneal thickness, development of microcysts, pigmented arcs, and fibrillary lines are reviewed. The safety of ortho-k is extensively reviewed, along with an overview of non-compliant behaviours and appropriate disinfection regimens. Finally, the role of ortho-k in myopia management for children is discussed in terms of efficacy, safety, and potential mechanisms of myopia control, including the impact of factors such as initial fitting age, baseline refractive error, the role of peripheral defocus, higher order aberrations, pupil size, and treatment zone size.

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Section: Oxidative Systemsmentioning

confidence: 99%

BCLA CLEAR - Orthokeratology

Vincent

Cho

Chan³

et al. 2021

Contact Lens and Anterior Eye

Self Cite

115

103

View full text Add to dashboard Cite

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“…7 Neutralization typically requires at least 6 hr, which can be an inconvenience for patients and may explain why more patients reported using MPS systems. 19 Another factor contributing to the lower usage of H2O2 may be practitioner apprehension about recommending H2O2 to patients, presumably because of concerns about patient compliance with the neutralization requirement and/or long term storage of CLs in neutralized peroxide solution. 20,21 However, only about 1% of H2O2 patients in this study reported having possible peroxide exposure leading to ocular discomfort.…”

Section: Discussionmentioning

confidence: 99%

Frequency of Contact Lens Complications Between Contact Lens Wearers Using Multipurpose Solutions Versus Hydrogen Peroxide in the United States and Canada

Tichenor

Cofield

Gann

et al. 2020

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Objectives: To retrospectively compare frequency of contact lens (CL) complications in soft CL users of hydrogen peroxide (H2O2) and multipurpose solutions (MPS). Methods: This was a multicenter, retrospective chart review of CL records from each patient's three most recent eye examinations at academic and private practices. Patients must have used the same solution type for at least 3 years. Univariate analyses were conducted using t tests, and chi-square or Fisher's exact test for categorical measures. Results: There were 1,137 patients included, with 670 (59%) using MPS and 467 (41%) H2O2. In total, 706 (62%) experienced at least one complication; 409 used MPS and 297 used H2O2. There was no difference in the proportion of patients experiencing at least one complication between MPS (61%) and H2O2 (64%) (P¼0.38). Multipurpose solutions users were more likely to report discomfort compared with H2O2 users (P¼0.04). Presumed microbial keratitis was experienced by 16 MPS and nine H2O2 users (P¼0.60). Conclusions: No significant differences were found in the frequency of CL complications between MPS and H2O2. H2O2 users were less likely to report discomfort and thus switching to a H2O2 system may be an alternative in CL users with discomfort.

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The Case for Using Hydrogen Peroxide Contact Lens Care Solutions: A Review

Nichols

Chalmers

Dumbleton

et al. 2019

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Despite their established disinfection and safety benefits, the use of hydrogen peroxide (H2O2) lens care systems among today's wearers of reusable contact lenses remains low in comparison with multipurpose solution (MPS) use. Multipurpose solution systems, however, present several potential drawbacks that may impact patient outcomes, including the use of chemical preservatives for disinfection, biocompatibility issues, and challenges with respect to lens care compliance. Given their unique composition and mechanism of action, one-step H2O2 systems offer the opportunity to avoid many of the challenges associated with MPS use. This article reviews the evolution of H2O2 lens care systems and examines the current scientific and clinical evidence regarding the relative ease of use, lens and tissue compatibility, disinfection efficacy, and ocular surface safety of H2O2 systems. Evaluation of the available data indicates that in comparison with MPS, one-step H2O2 systems tend to promote more favorable compliance, efficacy, comfort, and ocular surface outcomes for a wide range of contact lens–wearing patients. Based on the current published evidence, the authors recommend that eye care practitioners consider making one-step H2O2 systems their first-line contact lens care recommendation for most wearers of reusable lenses.

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Impact of Protein and Lipid on Neutralization Times of Hydrogen Peroxide Care Regimens

Cited by 4 publications

References 26 publications

BCLA CLEAR - Orthokeratology

BCLA CLEAR - Orthokeratology

Frequency of Contact Lens Complications Between Contact Lens Wearers Using Multipurpose Solutions Versus Hydrogen Peroxide in the United States and Canada

The Case for Using Hydrogen Peroxide Contact Lens Care Solutions: A Review

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