2009
DOI: 10.1093/europace/eup082
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Impact of pulmonary vein isolation on the autonomic modulation in patients with paroxysmal atrial fibrillation and prolonged sinus pauses

Abstract: Although the parasympathetic modulation was significantly attenuated after the PVI procedure, the mean heart rate did not increase in the BTS patients, probably due to the pre-existing sinus node dysfunction.

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Cited by 25 publications
(15 citation statements)
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“…Vagal stimulation could induce and maintain AF, whereas such induction was abolished following ablation of vagal inputs to the atria (31,32). Lowering vagal inputs by pulmonary vein isolation or use of class I antiarrhythmic drugs may explain their success in reducing AF recurrence (33-36) Also, a drop in blood pressure after 2 min of standing from a supine position reflects vascular sympathetic input and response, and has been associated with higher AF incidence (13,37). …”
Section: Discussionmentioning
confidence: 99%
“…Vagal stimulation could induce and maintain AF, whereas such induction was abolished following ablation of vagal inputs to the atria (31,32). Lowering vagal inputs by pulmonary vein isolation or use of class I antiarrhythmic drugs may explain their success in reducing AF recurrence (33-36) Also, a drop in blood pressure after 2 min of standing from a supine position reflects vascular sympathetic input and response, and has been associated with higher AF incidence (13,37). …”
Section: Discussionmentioning
confidence: 99%
“…As previously stated, paroxysmal AF can lead to reversible SND. Clinical studies have reported that curative catheter ablation of AF can abolish or remarkably diminish both symptomatic and asymptomatic sinus pauses on AF termination . On the basis of the ACC/AHA/HRS guidelines, all ABL group patients in our study had an indication for permanent pacing before undergoing catheter ablation .…”
Section: Prolonged Sinus Pauses On Af Termination: Pace or Ablate?mentioning
confidence: 99%
“…Increased vagal tone is thought to play a pathophysiological role in a subset of patients with AF . Numerous investigators have demonstrated that radiofrequency (RF) applications in the proximity of the pulmonary veins often induce vagal reflexes,, yet there is insufficient evidence regarding the association between autonomic modification, by ablation of vagal nerve ganglia in the proximity of the pulmonary veins, and AF recurrence ,. Therefore, in a series of consecutive patients undergoing CPVI for paroxysmal or persistent AF, we assessed the impact of CPVI on heart rate variability (HRV) indices, in turn, reflecting the impact of this procedure on vagal denervation, and evaluated the relationship between autonomic modification and recurrence of atrial arrhythmia (AA: AF, atrial flutter (AFL), or atrial tachycardia (AT)) over a year follow‐up.…”
Section: Introductionmentioning
confidence: 99%