Impact of quantitative index derived from 123I-FP-CIT-SPECT on reconstruction with correction methods evaluated using a 3D-striatum digital brain phantom

Furuta, Akiko; Onishi, Hideo; Yamaki, Noriyasu; Yada, Nobuhiro; Amijima, Hizuru

doi:10.1007/s12194-018-0468-z

Cited by 4 publications

(3 citation statements)

References 18 publications

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“…This overestimation was because the contrast between the striatum and BG was overemphasized due to over‐correction by SC, AC, and PVC. It has been reported that SC and AC improve the quantitative evaluation compared to no corrections 6,7,14,24 . In addition to SC and AC, PVC also has been reported to be valuable in quantitative evaluation 6,7 .…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that SC and AC improve the quantitative evaluation compared to no corrections. 6,7,14,24 In addition to SC and AC,PVC also has been reported to be valuable in quantitative evaluation. 6,7 Although the SBR is overestimated by the over-correction, these SBRs did not indicate the absolute theoretical SBRs calculated by the actual count density of 123 I solution filled into the phantom.…”

Section: Discussionmentioning

confidence: 99%

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Novel approach to semi‐quantification of tracer accumulation in dopamine transporter scan

Ito

Fujita

Hara

et al. 2022

J Applied Clin Med Phys

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Purpose Accurate tracer accumulation evaluation is difficult owing to the partial volume effect (PVE). We proposed a novel semi‐quantitative approach for measuring the accumulation amount by examining the approximate image. Using a striatal phantom, we verified the validity of a newly proposed method to accurately evaluate the tracer accumulations in the caudate and putamen separately. Moreover, we compared the proposed method with the conventional methods. Methods The left and right caudate/putamen regions and the whole brain region as background were identified in computed tomography (CT) images obtained by single‐photon emission computed tomography (SPECT)/CT and acquired the positional information of each region. SPECT‐like images were generated by assigning assumed accumulation amounts to each region. The SPECT‐like image, approximated to the actual measured SPECT image, was examined by changing the assumed accumulation amounts assigned to each region. When the generated SPECT‐like image most approximated the actual measured SPECT image, the accumulation amounts assumed were determined as the accumulation amounts in each region. We evaluated the correlation between the count density calculated by the proposed method and the actual count density of the 123I solution filled in the phantom. Conventional methods (CT‐guide method, geometric transfer matrix [GTM] method, region‐based voxel‐wise [RBV] method, and Southampton method) were also evaluated. The significance of differences between the correlation coefficients of various methods (except the Southampton method) was evaluated. Results The correlation coefficients between the actual count density and the SPECT count densities were 0.997, 0.973, 0.951, 0.950, and 0.996 for the proposed method, CT‐guide method, GTM method, RBV method, and Southampton method, respectively. The correlation of the proposed method was significantly higher than those of the other methods. Conclusions The proposed method could calculate accurate accumulation amounts in the caudate and putamen separately, considering the PVE.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Novel approach to semi‐quantification of tracer accumulation in dopamine transporter scan

Ito

Fujita

Hara

et al. 2022

J Applied Clin Med Phys

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“…This overestimation is considered since the contrast between the striatum and the BG was overemphasized due to over-correction produced by SC, AC, and PVC. It has been reported that the SC and the AC improve the quantitative evaluation compared to no corrections [11][12][13][14]. In addition to the SC and AC, PVC also has been reported to be valuable in quantitative evaluation [13,14].…”

Section: Discussionmentioning

confidence: 99%

New Semi-Quantification Approach for Dopamine Transporter Scan: Quantification of Accumulation by Examining the Approximate Image

Ito

Fujita

Hara

et al. 2020

Preprint

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BackgroundSemi-quantitative analysis is used to evaluate the degree of tracer binding to the striatum in dopamine transporter (DaT) single-photon emission computed tomography (SPECT). In DaT SPECT, it is difficult to evaluate the accurate tracer accumulation due to the partial volume effect (PVE). In this study, we propose a novel semi-quantitative approach for measuring the amount of accumulation by examining the approximate image. Using the striatal phantom, we verified the validity of a newly proposed method that can accurately evaluate the tracer accumulations in the caudate and putamen, separately.MethodsThe left and right caudate/putamen regions, and the whole brain region as the background (BG) region were identified in computed tomography (CT) images obtained by SPECT/CT imaging, and the positional information of each region was obtained. The SPECT-like images were generated by assigning assumed accumulation amounts to the left and right caudate/putamen and BG regions based on the positional information. By changing the assumed accumulation amounts assigned to each region, the SPECT-like image, which was approximated to the image obtained by the SPECT imaging, was examined. The accumulation amounts assumed, when the generated SPECT-like image approximated the most to the image actually obtained by the SPECT imaging, were determined as the accumulation amounts in each region. We evaluated the correlation between the count density calculated by the proposed method and the actual count density of 123I solution filled into the striatal phantom, and verified the validity of the proposed method. In addition, the specific binding ratio (SBR) and caudate-putamen ratio (CPR) computed by the proposed method were compared with the theoretical SBR and CPR calculated by the count density of the 123I solution filled into the striatal phantom.ResultsThe count density calculated by the proposed method and the count density of 123I solution filled in the striatal phantom had an extremely strong positive correlation (r=0.997, p < 0.001). The SBRs computed by the proposed method were overestimated. However, the obtained CPRs were very similar to the theoretical CPRs.ConclusionsThe proposed method was able to compute the accurate accumulation amounts in the caudate and putamen, considering the PVE.

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Distinctive regional asymmetry in dopaminergic and serotoninergic dysfunction in degenerative Parkinsonisms

Takahashi

Ishii

Sousa

et al. 2021

Journal of the Neurological Sciences

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Impact of quantitative index derived from 123I-FP-CIT-SPECT on reconstruction with correction methods evaluated using a 3D-striatum digital brain phantom

Cited by 4 publications

References 18 publications

Novel approach to semi‐quantification of tracer accumulation in dopamine transporter scan

Novel approach to semi‐quantification of tracer accumulation in dopamine transporter scan

New Semi-Quantification Approach for Dopamine Transporter Scan: Quantification of Accumulation by Examining the Approximate Image

Distinctive regional asymmetry in dopaminergic and serotoninergic dysfunction in degenerative Parkinsonisms

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